Differential expression of KIF11 in cancers of the breast.

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the kinesin family member 11, KIF11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KIF11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. KIF11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KIF11 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. KIF11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of TUFT1 in cancers of the breast.

10.31219/osf.io/3rk7f ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the tuftelin 1, TUFT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TUFT1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TUFT1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TUFT1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal and luminal A subtype cancer. TUFT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of hematological and neurological expressed 1 in cancers of the breast.

10.31219/osf.io/y9xjm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the hematological and neurological expressed 1, HN1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. HN1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. HN1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of HN1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer. HN1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of GINS1 in cancers of the breast.

10.31219/osf.io/xu4cs ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the GINS complex subunit 1, GINS1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. GINS1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. GINS1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of GINS1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. GINS1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of TPX2 in cancers of the breast.

10.31219/osf.io/zq3nm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the TPX2, microtubule-associated homolog, TPX2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TPX2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TPX2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TPX2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. TPX2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of NUSAP1 in cancers of the breast.

10.31219/osf.io/kn2gm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the nucleolar and spindle associated protein 1, NUSAP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. NUSAP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. NUSAP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of NUSAP1 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. NUSAP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CKS2 in cancers of the breast.

10.31219/osf.io/zdhr3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Regulatory Subunit ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the CDC28 protein kinase regulatory subunit 2, CKS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CKS2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CKS2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CKS2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. CKS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of dCTP pyrophosphatase 1 in cancers of the breast.

10.31219/osf.io/6qphv ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Tissue Analysis ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dCTP pyrophosphatase 1, DCTPP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCTPP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DCTPP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCTPP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer. DCTPP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of the integrator complex subunit 7 in cancers of the breast.

10.31219/osf.io/zkftb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Luminal A ◽

Gene Encoding ◽

Primary Tumors ◽

Free Survival ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the integrator complex subunit 7, INTS7, when comparing primary tumors of the breast to the tissue of origin, the normal breast. INTS7 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of INTS7 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal A and HER2+ type cancers, but contrarily. INTS7 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of NACC1 in cancers of the breast.

10.31219/osf.io/gbk9w ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Luminal B ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding nucleus accumbens associated 1, NACC1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. NACC1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. NACC1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of NACC1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer. NACC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of PDZ domain containing 11 in cancers of the breast.

10.31219/osf.io/785mt ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Pdz Domain ◽

Normal Breast ◽

Gene Encoding ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the PDZ domain containing 11, PDZD11, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDZD11 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. PDZD11 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDZD11 in primary tumors of the breast was correlated with overall survival in patients with HER2+ cancer. PDZD11 may be of relevance to initiation, maintenance or progression of cancers of the female breast.