scholarly journals HLö-7 - A REVIEW OF ACETYLCHOLINESTERASE REACTIVATOR AGAINST ORGANOPHOSPHOROUS INTOXICATION

2017 ◽  
Vol 86 (2) ◽  
pp. 70-83 ◽  
Author(s):  
Miroslav Psotka ◽  
David Maliňák ◽  
Lukáš Gorecki ◽  
Thuy Duong Nguyen ◽  
Ondřej Soukup ◽  
...  
Keyword(s):  
Hlö 7

scholarly journals ON THE UNIVERSALITY OF OXIME HLö-7 - ANTIDOTE FOR CASE OF THE NERVE AGENT POISONING

2011 ◽  
Vol 80 (2) ◽  
pp. 80-84 ◽  
Author(s):  
Kamil Kuča ◽  
Kamil Musílek ◽  
Jana Karasová ◽  
Daniel Jun ◽  
Ondřej Soukup ◽  
...  
Keyword(s):  
Nerve Agent ◽  
Hlö 7

Effects of Atropine and Soman on the Pharmacokinetics of the Oxime HLÖ 7 Dimethanesulfonate in Anesthetized Guinea-Pigs

1995 ◽  
Vol 18 (2-3) ◽  
pp. 137-149 ◽  
Author(s):  
Franz Worek ◽  
Reiner Klimmek ◽  
Ladislaus Szinicz
Keyword(s):  
Guinea Pigs ◽  
Hlö 7

Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function

1994 ◽  
Vol 68 (4) ◽  
pp. 231-239 ◽  
Author(s):  
Franz Worek ◽  
Thomas Kirchner ◽  
Ladislaus Szinicz
Keyword(s):  
Guinea Pigs ◽  
Hi 6 ◽  
Hlö 7 ◽  
Circulatory Function

HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases

1992 ◽  
Vol 66 (9) ◽  
pp. 603-621 ◽  
Author(s):  
P. Eyer ◽  
I. Hagedorn ◽  
R. Klimmek ◽  
P. Lippstreu ◽  
M. Löffler ◽  
...  
Keyword(s):  
Hlö 7

Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats

1994 ◽  
Vol 68 (4) ◽  
pp. 224-230 ◽  
Author(s):  
Herman P. M. van Helden ◽  
Herma J. van der Wiel ◽  
Jelly J. Zijlstra ◽  
Bert P. C. Melchers ◽  
Ruud W. Busker
Keyword(s):  
Acetylcholinesterase Inhibition ◽  
Therapeutic Effects ◽  
Hi 6 ◽  
Hlö 7 ◽  
Hgg 12

scholarly journals A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice

1998 ◽  
Vol 41 (1) ◽  
pp. 19-21 ◽  
Author(s):  
Jiří Kassa
Keyword(s):  
Therapeutic Efficacy ◽  
Nerve Agent ◽  
Hi 6 ◽  
Hlö 7

1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI- 6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.

The bispyridinium-dioxime HLö-7

1989 ◽  
Vol 38 (4) ◽  
pp. 633-640 ◽  
Author(s):  
Leo P.A. de Jong ◽  
Marcel A.A. Verhagen ◽  
Jan P. Langenberg ◽  
Ilse Hagedorn ◽  
Marlene Löffler
Keyword(s):  
Hlö 7

A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods

1999 ◽  
Vol 18 (9) ◽  
pp. 560-565 ◽  
Author(s):  
J Kassa ◽  
J Cabal
Keyword(s):  
Therapeutic Efficacy ◽  
Hi 6 ◽  
Hlö 7

1 The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/-2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) by in vitro and in vivo methods. 2 Our results confirm that the new oxime BI-6 is a significantly more efficacious acetylcholinesterase reactivator than currently available pralidoxime and obidoxime but not as effective as H oximes (HI-6, HLö-7) in vitro as well as in vivo. In addition, the oxime BI-6 is able to protect supralethal sarin poisoned rats at human-relevant doses. 3 Our data also suggest that the potency of oximes tested to reactivate sarin-inhibited acetylcholinesterase in vitro closely corresponds to their reactivating efficacy in vivo and their ability to protect rats poisoned with supralethal doses of sarin.

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