ON THE UNIVERSALITY OF OXIME HLö-7 - ANTIDOTE FOR CASE OF THE NERVE AGENT POISONING

1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI- 6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.

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In Vitro Potency of H Oximes (HI-6, HLö-7), the Oxime BI-6, and Currently Used Oximes (Pralidoxime, Obidoxime, Trimedoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase

Journal of Toxicology and Environmental Health Part A ◽

10.1080/15287390500364283 ◽

2006 ◽

Vol 69 (15) ◽

pp. 1431-1440 ◽

Cited By ~ 7

Author(s):

Kamil Kuca ◽

Jiri Cabal ◽

Jiri Kassa ◽

Daniel Jun ◽

Martina Hrabinova

Keyword(s):

Rat Brain ◽

Nerve Agent ◽

Hi 6 ◽

Hlö 7 ◽

Brain Acetylcholinesterase

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Synthesis and Molecular Properties of Nerve Agent Reactivator HLö-7 Dimethanesulfonate

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.9b00021 ◽

2019 ◽

Vol 10 (5) ◽

pp. 761-766 ◽

Cited By ~ 2

Author(s):

Fu-Lian Hsu ◽

Su Y. Bae ◽

Jack McGuire ◽

Dana R Anderson ◽

Stephanie M. Bester ◽

...

Keyword(s):

Nerve Agent ◽

Molecular Properties ◽

Hlö 7

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A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2018.36 ◽

2005 ◽

Vol 48 (2) ◽

pp. 81-86 ◽

Cited By ~ 14

Author(s):

Kamil Kuča ◽

Jiří Cabal ◽

Jiří Kassa ◽

Daniel Jun ◽

Martina Hrabinová

Keyword(s):

Rat Brain ◽

Nerve Agents ◽

Nerve Agent ◽

The Other ◽

In Vitro Evaluation ◽

In Vitro Methods ◽

Hi 6 ◽

Hlö 7 ◽

Brain Acetylcholinesterase

1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro. 3. Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6.

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