scholarly journals Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma?

2006 ◽  
Vol 21 (6) ◽  
pp. 1-4 ◽  
Author(s):  
Ahmet Şengöz ◽  
Erol Taşdemiroğlu ◽  
Halit Togay
Keyword(s):  
Malignant Melanoma ◽  
Nerve Root ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Histopathological Diagnosis ◽  
Total Resection ◽  
Cell Sarcoma ◽  
Melanotic Schwannoma ◽  
Psammomatous Melanotic Schwannoma

✓The authors present a case of clear cell sarcoma (CCS) in which the tumor originated in the S-1 nerve root and had been previously diagnosed as psammomatous melanotic schwannoma (PMS). This is the third case of a spinal nerve root origin for CCS reported in the English-language literature. The similar histogenesis of CCS and malignant melanoma supports the hypothesis that biological agents or immunotherapy are potentially important areas of investigation. The patient underwent S1–3 laminectomy and gross-total resection of the mass lesion. The border of the resection was extended 1 cm distal to the tumor margin. The postoperative period was uneventful. The new histopathological diagnosis was CCS (malignant melanoma of soft tissue). Despite total resection, the patient returned with disseminated disease at the 18-month follow-up visit. His follow-up magnetic resonance image of the lumbar spine revealed sacral L5–S3 involvement of the vertebral bodies along with disseminated cauda equina seeding. A CCS originating from peripheral nerves is quite rare. The histopathological and immunohistochemical appearance of CCSs resembles those of PMSs. Surgery should be the first choice of treatment.

scholarly journals Clear cell sarcoma of the kidney in a 62-year-old patient presenting with generalized pruritus

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuxi Zhang ◽  
Jun Li ◽  
Yan Wang
Keyword(s):  
Clear Cell ◽  
Wilms Tumor ◽  
Clear Cell Sarcoma ◽  
Histopathological Diagnosis ◽  
Ki 67 ◽  
Case Presentation ◽  
Cell Sarcoma ◽  
Underlying Malignancy ◽  
Neural Cell Adhesion

Abstract Background Clear cell sarcoma of the kidney (CCSK) is the second most common renal tumor in children following Wilms’ tumor. CCSK is extremely rare in adults, with only 25 adult cases reported in the medical literature. Case presentation We reported a 62-year-old man with a right renal mass presenting only with generalized pruritus who underwent radical right nephrectomy. With immunostaining, tumor cells were positive for expressed vimentin, neural cell adhesion molecule (NCAM, CD56), and Ki-67 and focally positive for p53, CD10 and Bcl-2. The histopathological diagnosis was CCSK. Two weeks after the operation, the generalized pruritus ended. One month after the operation, the patient started treatment with a regimen combining doxorubicin, vincristine, cyclophosphamide, and etoposide. At the 20-month follow-up visit, there was no evidence of local recurrence or metastases. Conclusions In a patient presenting with generalized pruritus, further evaluation for an underlying malignancy should be considered. It is difficult to distinguish CCSK from undifferentiated renal neoplasms. Immunohistochemistry could help to make exact histopathological diagnoses. The BCL-6 corepressor (BCOR) gene could play a significant role in CCSK tumorigenesis and be a good marker for CCSK diagnosis. Surgery with combination chemotherapy and radiation therapy could be used to treat CCSK in older patients.

scholarly journals A long-term survivor of clear cell sarcoma-like tumor of the gastrointestinal tract with liver metastasis: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Takuhisa Okada ◽  
Yasumitsu Hirano ◽  
Shintaro Ishikawa ◽  
Hiroka Kondo ◽  
Toshimasa Ishii ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Node ◽  
Gastrointestinal Tract ◽  
Liver Metastasis ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

Abstract Background Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLTGT) is extremely rare. It is a mesenchymal neoplasm that usually forms in the small intestine of adolescents and young adults, is prone to local recurrence and metastasis, and has a high mortality rate. We report a patient with CCSLTGT with lymph node- and liver metastases, who continues to survive 6 years after initial surgical resection. Case presentation A 38-year-old woman presented with lightheadedness. Laboratory analysis revealed anemia (hemoglobin, 6.7 g/dL), and enhanced computed tomography (CT) demonstrated a mass in the small intestine, about 6 cm in diameter, with swelling of 2 regional lymph nodes. Double-balloon small intestine endoscopic examination revealed a tumor accompanied by an ulcer; the biopsy findings suggested a primary cancer of the small intestine. She was admitted, and we then performed a laparotomy for partial resection of the small intestine with lymph node dissection. Pathologic examination revealed CCSLTGT with regional lymph node metastases. About 3 years later, follow-up CT revealed a single liver metastasis. Consequently, she underwent a laparoscopic partial liver resection. Histopathologic examination confirmed that the liver metastasis was consistent with CCSLTGT. It has now been 3 years without a recurrence. Conclusion Repeated radical surgical resection with close follow-up may be the only way to achieve long-term survival in patients with CCLSTGT.

Malignant Melanoma of Soft Parts (Clear Cell Sarcoma): A Case Report

2003 ◽  
Vol 30 (7) ◽  
pp. 550-555 ◽  
Author(s):  
Takuya Seike ◽  
Kazuya Matsumoto ◽  
Hideki Nakanishi ◽  
Ichiro Hashimoto ◽  
Yoshiaki Kubo ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

Epithelial-Type and Neural-Type Cadherin Expression in Malignant Noncarcinomatous Neoplasms With Epithelioid Features That Involve the Soft Tissues

2002 ◽  
Vol 126 (4) ◽  
pp. 425-431 ◽  
Author(s):  
William B. Laskin ◽  
Markku Miettinen
Keyword(s):  
Malignant Melanoma ◽  
Synovial Sarcoma ◽  
Soft Tissues ◽  
Clear Cell ◽  
Epithelioid Sarcoma ◽  
Clear Cell Sarcoma ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Cell Sarcoma ◽  
Myxoid Chondrosarcoma ◽  
Poorly Differentiated

Abstract Context.—Transmembrane adhesion molecules, epithelial-type cadherin (ECAD) and neural-type cadherin (NCAD), help in regulating transformations between epithelial and mesenchymal cells in the developing embryo and in maintaining the epithelioid phenotype. Consequently, the presence of epithelioid cells in certain malignant noncarcinomatous neoplasms raises speculation that the expression of ECAD and NCAD in these neoplasms may have diagnostic significance. Objective.—To investigate the utility of ECAD and NCAD immunoexpression in distinguishing malignant (noncarcinomatous) neoplasms with epithelioid features that involve the soft tissues. Design.—Membranous immunoreactivity of anti-ECAD and anti-NCAD was evaluated on archived cases selected from the files of the Armed Forces Institute of Pathology. Results.—Epithelial-type cadherin was found in biphasic synovial sarcoma (35 of 35 cases), malignant melanoma (13/21), monophasic fibrous synovial sarcoma (13/26), clear cell sarcoma (4/9), poorly differentiated synovial sarcoma (3/13), diffuse mesothelioma (4/20), malignant epithelioid peripheral nerve sheath tumor (1/6), and epithelioid sarcoma (5/62). Neural-type cadherin was observed in chordoma (11/11), biphasic synovial sarcoma (30/35), diffuse mesothelioma (14/20), malignant melanoma (14/25), epithelioid sarcoma (24/63), epithelioid angiosarcoma (1/4), poorly differentiated synovial sarcoma (2/13), clear cell sarcoma (1/10), and monophasic fibrous synovial sarcoma (1/26). Eighteen cases of primary cutaneous squamous cell carcinomas all tested positive for ECAD, whereas NCAD was focally observed in 5 cases. No expression of either molecule was observed in cases of epithelioid hemangioendothelioma (n = 9), alveolar soft part sarcoma (n = 8), and extraskeletal myxoid chondrosarcoma (n = 7). Conclusions.—Epithelial-type and neural-type cadherins are found in a variety of noncarcinomatous neoplasms with epithelioid features that involve the soft tissues and can be utilized, in association with other immunomarkers, in distinguishing chordoma (100% NCAD) from extraskeletal myxoid chondrosarcoma and conventional chondrosarcoma of bone (0% NCAD), squamous cell carcinoma (100% ECAD) from epithelioid sarcoma (8% ECAD), and biphasic synovial sarcoma (100% ECAD) from diffuse mesothelioma (20% ECAD).

Clear cell sarcoma with intraepidermal nests requiring the differential diagnosis of malignant melanoma

2017 ◽  
Vol 45 (1) ◽  
pp. 115-116 ◽  
Author(s):  
Takayuki Fusumae ◽  
Koji Kamiya ◽  
Takeo Maekawa ◽  
Mayumi Komine ◽  
Satoru Murata ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

scholarly journals A Rare Case of Clear Cell Sarcoma (Malignant Melanoma of Soft Parts) Diagnosed in Pleural Effusion Cytology

2016 ◽  
Vol 146 (suppl_1) ◽  
Author(s):  
Khurram Shafique ◽  
Afra Samad ◽  
Arslan Ahmad ◽  
Flores Alfonso ◽  
Arbaz Samad
Keyword(s):  
Pleural Effusion ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

scholarly journals Primary malignant melanoma (clear cell sarcoma) of bone: Report of a case arising in the ulna

Cancer ◽  
1996 ◽  
Vol 77 (12) ◽  
pp. 2471-2475 ◽  
Author(s):  
Ryohei Yokoyama ◽  
Kiyoshi Mukai ◽  
Teruyuki Hirota ◽  
Yasuo Beppu ◽  
Hisatoshi Fukuma
Keyword(s):  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Primary Malignant Melanoma ◽  
Cell Sarcoma

Clear cell sarcoma of tendons and aponeuroses with t(12;22) (q13;q12) diagnosed initially as malignant melanoma

1996 ◽  
Vol 91 (1) ◽  
pp. 37-39 ◽  
Author(s):  
Bogusław Nedoszytko ◽  
Krzysztof Mrózek ◽  
Andrzej Roszkiewicz ◽  
Andrzej Kopacz ◽  
Maciej Świerblewski ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

Hyperthermic Antiblastic Perfusion in the Treatment of Cancer of the Extremities

1985 ◽  
Vol 71 (4) ◽  
pp. 355-359 ◽  
Author(s):  
Maurizio Vaglini ◽  
Salvatore Andreola ◽  
Angelo Attili ◽  
Filiberto Belli ◽  
Raffaele Marolda ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Clear Cell ◽  
Remission Rate ◽  
Osteogenic Sarcoma ◽  
Major Complication ◽  
Clear Cell Sarcoma ◽  
Clinical Results ◽  
Cell Sarcoma

From February 1982 to December 1983, 42 patients affected by neoplasms of the limbs were treated at the Istituto Nazionale Tumori of Milan by hyperthermic antiblastic perfusion in extracorporeal circulation at the temperature of 40-41 °C for 1 h. Thirty-two were affected by melanoma, 4 by osteogenic sarcoma, 2 by squamous-cell carcinoma, 1 by liposarcoma, 1 by hemangiopericytoma, 1 by clear-cell sarcoma and 1 by Kaposis's sarcoma. As regards the immediate response, a complete plus partial remission rate of 88 % without any major complication was obtained. The follow-up period is too short for any considerations about overall survival. However, because of these good clinical results we consider this method able to locally control the evolution of neoplasms of the extremities, allowing in many cases a limb salvage.

Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma

2012 ◽  
Vol 43 (9) ◽  
pp. 1463-1470 ◽  
Author(s):  
Linlin Yang ◽  
Yuan Chen ◽  
Tiantian Cui ◽  
Thomas Knösel ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma
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