Influence of Specific Serum Therapy on Plasma Lipids in Pneumonia.

1940 ◽  
Vol 43 (1) ◽  
pp. 168-170
Author(s):  
A. V. Stoesser
Keyword(s):  
Plasma Lipids ◽  
Specific Serum ◽  
Serum Therapy

Experimental Specific Serum Therapy of Staphylococcus.

1966 ◽  
Vol 123 (2) ◽  
pp. 356-361
Author(s):  
B. Campbell ◽  
E. L. Lassila
Keyword(s):  
Specific Serum ◽  
Serum Therapy

scholarly journals Bacteriæmia in Pneumonia

1933 ◽  
Vol 26 (9) ◽  
pp. 1139-1144 ◽  
Author(s):  
G. J. Langley
Keyword(s):  
Specific Treatment ◽  
Blood Cultures ◽  
Direct Result ◽  
Specific Serum ◽  
Serum Therapy

Tables are shown which record the course of bacteriæmia investigated by frequent blood-cultures in a series of cases of pneumonia. The proportion of cases having a bacteriæmia in the course of the disease agrees fairly closely with other findings both in this country and in America. Attention is drawn to the frequency with which the organisms disappear from the blood in the absence of any specific treatment, and to the frequency of recovery of bacteriæmic cases. It is therefore submitted that it is unsafe to regard the disappearance of a bacteriæmia as the direct result of specific serum treatment, and that this cannot be used as evidence of successful serum therapy.

scholarly journals A STUDY OF THE THERAPEUTIC MECHANISM OF ANTI-PNEUMOCOCCIC SERUM ON THE EXPERIMENTAL DERMAL PNEUMOCOCCUS INFECTION IN RABBITS

1933 ◽  
Vol 58 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Arnold J. Gelarie ◽  
Albert B. Sabin
Keyword(s):  
Beneficial Effect ◽  
Combined Therapy ◽  
Specific Antiserum ◽  
Survival Ratio ◽  
Large Group ◽  
Specific Serum ◽  
Therapeutic Mechanism ◽  
Serum Therapy

The purpose of the present investigation was to determine whether or not non-specific agents were capable of exerting any influence on the response of pneumococcus-infected animals to specific serum therapy. It has been demonstrated in these experiments that whereas gold (empirically chosen) by itself had very little effect either on the course or the outcome of the experimental pneumococcus infection, it is nevertheless capable of exerting a definite and marked beneficial effect in rabbits treated with a subeffective dose of the specific antiserum. Of the rabbits treated with the subeffective dose of serum alone, 71 per cent died and only 29 per cent survived; the additional administration of gold reversed this death-survival ratio with the result that of a large group of rabbits which received the combined therapy, 77 per cent survived and only 23 per cent died.

scholarly journals Specific Serum Therapy in Typhoid

BMJ ◽  
1944 ◽  
Vol 2 (4366) ◽  
pp. 339-340 ◽  
Author(s):  
A. E. Hodgson
Keyword(s):  
Specific Serum ◽  
Serum Therapy

scholarly journals THE EFFECT OF BACTERIAL VARIATION UPON THE FACTORS NECESSARY FOR THE PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES

1930 ◽  
Vol 52 (5) ◽  
pp. 781-803 ◽  
Author(s):  
Gregory Shwartzman
Keyword(s):  
Infectious Diseases ◽  
Bacterial Culture ◽  
Immune Serum ◽  
Colony Morphology ◽  
Partial Loss ◽  
Local Skin ◽  
Specific Serum ◽  
Skin Reactivity ◽  
Agglutination Titer ◽  
Serum Therapy

In this paper there is reported the effect of bacterial variation upon the reacting factors of the phenomenon of local skin reactivity to bacterial culture filtrates. By means of the method described in the text the following results were obtained: Various stock strains of B. typhosus were found to produce reacting factors which differed in their neutralizability by anti-stock immune sera. The reacting factors of low neutralizability also possessed low antigenicity. The passage of strains through mice brought about in one instance a lowering of neutralizability of reacting factors and in another instance had no effect. It was possible to increase the antigenicity of the reacting factors by passage of the strain through mice. Transformation of "stock" strain into "rough" brought about the formation of reacting factors of new specificity. The "rough" reacting factors were neutralized by homologous sera and also differed in their neutralizability. Reacting factors of various degrees of neutralizability were produced by stock strains which did not display any difference in colony appearance (with one exception). The "rough" reacting factors appeared in strains of typical "rough" colony morphology. However, "rough" strains of the same degree of roughness morphologically differed in the neutralizability of their reacting factors. The changes in neutralizability elicited by passage through mice had no influence on colony morphology. There seemed to be a parallelism between the degree of agglutinability of stock strains by anti-stock sera and the degree of neutralizability of reacting factors of the same strain. It was possible to obtain a partial loss of neutralizability by passage through mice with and without change in agglutinability. The agglutination titer of anti-rough serum was not an indication of its anti-rough neutralizing properties. The degree of neutralizability of "rough" reacting factors paralleled the specific serum agglutinability of the strains producing them. Abundant precipitation occurred in mixtures of toxic filtrates and immune serum in spite of low neutralization. The filtrates of rough cultures non-neutralizable by anti-stock sera failed to precipitate with the latter. The appearance of neutralizing anti-rough antibodies was coincident with the development of anti-rough precipitates. The rough strains possessed a lower virulence than the stock strains from which they were derived. However, there was no difference in the virulence of "rough" strains, the reacting factors of which differed in their neutralizability. The filtrates containing "rough" reacting factors were seemingly as lethal to mice and rabbits as were filtrates of stock cultures of B. typhosus. The possible relation of these findings to the immunological understanding of the course of infectious diseases and to serum therapy is discussed.

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