diagnosis and treatment
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2022 ◽  
Vol 14 (1) ◽  
pp. 334-347
Xiao-Cui Wei ◽  
Li-Juan Liu ◽  
Fan Zhu

2022 ◽  
Vol 23 (2) ◽  
pp. 932
Dmitry V. Korolev ◽  
Galina A. Shulmeyster ◽  
Natalia V. Evreinova ◽  
Maria S. Syrovatkina ◽  
Maria S. Istomina ◽  

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS2/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.

Emmanuel Musisi ◽  
Abdul Sessolo ◽  
Sylvia Kaswabuli ◽  
Josephine Zawedde ◽  
Patrick Byanyima ◽  

This paper highlights the value of stool as a sample type for diagnosis of tuberculosis. While other studies have used DNA-based assays like the Xpert MTB/RIF and culture to detect Mycobacterium tuberculosis in stool, this is the first study that has applied TB-MBLA, an RNA-based assay, to quantify TB bacteria in stool.

2022 ◽  
Vol 11 ◽  
Sherise D. Ferguson ◽  
Elena I. Fomchenko ◽  
Renato A. Guerrieri ◽  
Isabella C. Glitza Oliva

Leptomeningeal disease (LMD) is a devastating category of CNS metastasis with a very poor prognosis and limited treatment options. With maximal aggressive therapy, survival times remain short and, without treatment, prognosis is measured in weeks. Both LMD diagnosis and treatment are challenging topics within neuro-oncology. In this review, we discuss the advances in LMD diagnosis with a focus on the role of circulating tumor DNA (ctDNA) and discuss the role of targeted and immunotherapy in LMD treatment.

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