Spectrophotometric Determination of Atenolol by Formation of Ion Association Complex

1989 ◽  
Vol 22 (7) ◽  
pp. 1819-1827 ◽  
Author(s):  
R. A. Lorenzo Ferreira ◽  
M. L. Enseñat ◽  
M. L. Berea ◽  
F. Bermejo Martinez

Author(s):  
P. V. Lakshmana Rao ◽  
C. Rambabu

Objective: The authors report two simple, accurate and economic spectrophotometric methods A and B for the determination of Itopride hydrochloride in bulk and dosage forms.Methods: The proposed methods are based on the formation of chloroform soluble ion-associates in the presence of acidic dyes namely BPB (Method A) and BCP (Method B) exhibiting lmax at 418 and 418 nm respectively.Results: Beer’s law is found to be obeyed in the concentration range of 2.0-10.0 µg/ml and 2.0-10.0 µg/ml. The molar absorptivities are found to be 1.42x104 and 9.61x103L/mol. cm for methods A and B. These methods are successfully applied for the assay of Itopride hydrochloride in pharmaceutical formulations.


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