scholarly journals In vitro Study on Interaction of Ketotifen Fumerate with Paracetamol

IIUC Studies ◽  
2012 ◽  
Vol 7 ◽  
pp. 49-54
Author(s):  
Mohammed Aktar Sayeed ◽  
Sohel Rana
Keyword(s):  
Stability Constants ◽  
Aqueous Media ◽  
In Vitro Study ◽  
Vitro Study ◽  
Reaction Systems ◽  
The Stability

Interaction of ketotifen fumerate and paracetamol was studied in aqueous media. The ability of interaction of ketotifen with paracetamol is dependent on pH of the solution and it has been found that ketotifen forms 1:1 complexes at different pH. The stability constants have been calculated from the Ardon’s spectrophotomeric measurements of the reaction systems. When ketotifen was interacted with paracetamol and the absorbance was determined at 300 nm the stability constants were found of - 7.32 and -7.84 at pH 1.6 and 7.4 respectively. DOI: http://dx.doi.org/10.3329/iiucs.v7i0.12258 IIUC Studies Vol.7 2011: 49-54

scholarly journals In vitro study on the interaction of ketotifen fumarate with anhydrous theophylline

2012 ◽  
Vol 48 (2) ◽  
pp. 211-216
Author(s):  
Mohammed Aktar Sayeed ◽  
Razibul Habib ◽  
Mominur Rahman ◽  
Hasan Al Banna ◽  
Sohel Rana
Keyword(s):  
Stability Constants ◽  
Aqueous Media ◽  
In Vitro Study ◽  
Stable Complex ◽  
Concurrent Administration ◽  
Fixed Temperature ◽  
Ketotifen Fumarate ◽  
The Stability ◽  
Anhydrous Theophylline

The purpose of the present study was to investigate the interaction between ketotifen fumarate and anhydrous theophylline in aqueous media of various pH (1.2 and 6.8). Using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement methods, the values of the stability constants of theophylline with ketotifen were determined at a fixed temperature (37 ºC) at various pH. The stability constants, ranging between 5.66 and 9.92, were derived from Ardon's plot, indicating that comparatively stable complexes had formed as a result of an interaction between the drugs. However, following the interaction of theophylline with ketotifen, stability constants were <1 at gastric pH (1.2) and intestinal pH (6.8). Concurrent administration of ketotifen and theophylline could result in the formation of a stable complex and this is likely to reduce the therapeutic activities of both drugs.

In vitro Study on the Interaction of Caffeine with Gliclazide and Metformin in the Aqueous Media

2009 ◽  
Vol 4 (5) ◽  
pp. 194-204 ◽  
Author(s):  
Mohammad Mohiuddin ◽  
A.T.M. Zafrul Azam ◽  
Md. Shah Amran ◽  
Md. Amjad Hossain
Keyword(s):  
Aqueous Media ◽  
In Vitro Study ◽  
Vitro Study
Sign in / Sign up

Export Citation Format

Share Document