scholarly journals Narrowing the wingless-2 mutation to a 227 kb candidate region on chicken chromosome 12

2018 ◽  
Vol 97 (6) ◽  
pp. 1872-1880 ◽  
Author(s):  
A.E. Webb ◽  
I.A. Youngworth ◽  
M. Kaya ◽  
C.L. Gitter ◽  
E.A. O'Hare ◽  
...  
Keyword(s):  
Candidate Region ◽  
Chromosome 12 ◽  
Chicken Chromosome

scholarly journals Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12

2014 ◽  
Vol 307 (8) ◽  
pp. H1103-H1110 ◽  
Author(s):  
Sasha Z. Prisco ◽  
Jessica R. C. Priestley ◽  
Brian D. Weinberg ◽  
Anthony R. Prisco ◽  
Matthew J. Hoffman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Remodeling ◽  
Vascular Dysfunction ◽  
Candidate Region ◽  
Chromosome 12 ◽  
Dietary Salt ◽  
Hypertension Risk ◽  
Congenic Interval ◽  
Human Chromosome 7

We previously isolated a 6.1-Mb region of SS/Mcwi (Dahl salt-sensitive) rat chromosome 12 (13.4–19.5 Mb) that significantly elevated blood pressure (BP) (Δ+34 mmHg, P < 0.001) compared with the SS-12BN consomic control. In the present study, we examined the role of vascular dysfunction and remodeling in hypertension risk associated with the 6.1-Mb (13.4–19.5 Mb) locus on rat chromosome 12 by reducing dietary salt, which lowered BP levels so that there were no substantial differences in BP between strains. Consequently, any observed differences in the vasculature were considered BP-independent. We also reduced the candidate region from 6.1 Mb with 133 genes to 2 Mb with 23 genes by congenic mapping. Both the 2 Mb and 6.1 Mb congenic intervals were associated with hypercontractility and decreased elasticity of resistance vasculature prior to elevations of BP, suggesting that the vascular remodeling and dysfunction likely contribute to the pathogenesis of hypertension in these congenic models. Of the 23 genes within the narrowed congenic interval, 12 were differentially expressed between the resistance vasculature of the 2 Mb congenic and SS-12BN consomic strains. Among these, Grifin was consistently upregulated 2.7 ± 0.6-fold ( P < 0.05) and 2.0 ± 0.3-fold ( P < 0.01), and Chst12 was consistently downregulated −2.8 ± 0.3-fold ( P < 0.01) and −4.4 ± 0.4-fold ( P < 0.00001) in the 2 Mb congenic compared with SS-12BN consomic under normotensive and hypertensive conditions, respectively. A syntenic region on human chromosome 7 has also been associated with BP regulation, suggesting that identification of the genetic mechanism(s) underlying cardiovascular phenotypes in this congenic strain will likely be translated to a better understanding of human hypertension.

Mapping of the prolactin gene to chicken chromosome 2

1999 ◽  
Vol 30 (6) ◽  
pp. 462-478 ◽  
Author(s):  
Y-W Miao ◽  
D W Burt ◽  
I R Paton ◽  
P J Sharp ◽  
I C Dunn
Keyword(s):  
Chromosome 2 ◽  
Chicken Chromosome ◽  
Prolactin Gene

Mapping of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chicken chromosome 3

2001 ◽  
Vol 32 (1) ◽  
pp. 50-50
Author(s):  
S. F. Ge ◽  
M. N. Romanov ◽  
P. J. Sharp ◽  
D. W. Burt ◽  
I. R. Paton ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Receptor Gene ◽  
Chromosome 3 ◽  
Chicken Chromosome

Localization of MODY3 to a 5-cM region of human chromosome 12

Diabetes ◽  
1995 ◽  
Vol 44 (12) ◽  
pp. 1408-1413 ◽  
Author(s):  
S. Menzel ◽  
K. Yamagata ◽  
J. B. Trabb ◽  
J. Nerup ◽  
M. A. Permutt ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 12

Numerical Chromosome Aberrations in Fibrothecoma

1992 ◽  
Vol 78 (2) ◽  
pp. 140-142 ◽  
Author(s):  
Paola Dal Cin ◽  
Philippe Moerman ◽  
Ivo De Wever ◽  
Herman Van Den Berghe
Keyword(s):  
Chromosome Aberrations ◽  
Genital Tract ◽  
Cytogenetic Analysis ◽  
Female Genital Tract ◽  
Chromosome 12 ◽  
Mesenchymal Tumors ◽  
Extra Copy ◽  
Embryonic Origin ◽  
Numerical Chromosome ◽  
Female Genital

Cytogenetic analysis on a 7-day-old culture of a fibrothecoma showed only numerical chromosome abnormalities: 57, XX, +4, +5, +6, +10, + 12, +12, +14, +17, +18, +19, +20. The finding of an extra copy of chromosome 12 in mesenchymal tumors, mostly benign and originating from the female genital tract, may possibly point towards their common embryonic origin.

Candidate region aware nested named entity recognition

2021 ◽  
Author(s):  
Deng Jiang ◽  
Haopeng Ren ◽  
Yi Cai ◽  
Jingyun Xu ◽  
Yanxia Liu ◽  
...  
Keyword(s):  
Named Entity Recognition ◽  
Candidate Region ◽  
Entity Recognition ◽  
Named Entity
Sign in / Sign up

Export Citation Format

Share Document