scholarly journals Long-Term Clinical and Immunological Impact of Severe COVID-19 on a Living Kidney Transplant Recipient – A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Liru Qiu ◽  
Ji Zhang ◽  
Yafei Huang ◽  
Gen Chen ◽  
Zhishui Chen ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Clinical Decision Making ◽  
Kidney Transplant Recipient ◽  
Transplant Rejection ◽  
Clinical Decision ◽  
Renal Tubular Cells ◽  
Renal Tubular ◽  
Long Term Impact

The long-term impact of COVID-19 on transplant recipients remains unknown. We describe the case of a 30-year-old male kidney transplant recipient from Wuhan, China that was treated for severe COVID-19 in February 2020. He suffered an acute lung and renal injury and required systemic treatment including adjustment of his immunosuppressant regime. He was followed up to 1-year after discharge. No chronic lung fibrosis or deterioration of his pulmonary function was observed. Despite COVID-19 mediated damage to his renal tubular cells, no transplant rejection occurred. His immunological profile demonstrated both cellular anti-SARS-CoV-2 reactivity and specific humoral immunity, indicating that it is beneficial for the transplanted patients to be immunized with SARS-CoV-2 virus vaccine. This case will help guide clinical decision making for immunocompromised individuals that become infected with SARS-CoV-2.

scholarly journals Angiosarcoma of an Arteriovenous Fistula for Hemodialysis in a Kidney Transplant Recipient Affected by Lowe’s Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
V. D’Ambrosio ◽  
P. Silvestri ◽  
F. Aureli ◽  
A. Sturniolo ◽  
G. Grandaliano ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Arteriovenous Fistula ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Oculocerebrorenal Syndrome ◽  
Starting Point ◽  
Threatening Condition ◽  
Renal Tubular

Objective/Background. To describe an uncommon, life-threatening condition such as angiosarcoma of a fistula for hemodialysis occurring in a transplant recipient affected by Lowe’s syndrome. Summary. We present the case of a 56-year-old male kidney transplant recipient affected by Lowe’s syndrome, also known as oculocerebrorenal syndrome, a rare X-linked disorder characterized by congenital cataracts, hypotonia, intellectual disability, and Fanconi-like renal tubular dysfunction, who was diagnosed with angiosarcoma of a functioning arteriovenous fistula for hemodialysis. Conclusion. Angiosarcoma is a rare soft tissue tumor, and only 22 cases of angiosarcoma of arteriovenous fistulae were described so far; although a correlation between Lowe’s syndrome and a higher risk of tumor compared to the general population has not been described so far, the mechanisms of disease causation could be an interesting starting point for future studies on a possible connection between the two events.

scholarly journals Machine perfusion and long-term kidney transplant recipient outcomes across allograft risk strata

2018 ◽  
Vol 33 (7) ◽  
pp. 1251-1259 ◽  
Author(s):  
Shaifali Sandal ◽  
Xun Luo ◽  
Allan B Massie ◽  
Steven Paraskevas ◽  
Marcelo Cantarovich ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Machine Perfusion

scholarly journals Severe COVID-19 infection in a kidney transplant recipient treated with lopinavir/ritonavir, hydroxychloroquine and dexamethasone

2021 ◽  
Vol 15 (09) ◽  
pp. 1257-1262
Author(s):  
Satriyo Dwi Suryantoro ◽  
Mochammad Thaha ◽  
Pranawa ◽  
Djoko Santoso ◽  
Nunuk Mardiana ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Transplant Rejection ◽  
Immunosuppressive Agents ◽  
Immunosuppressive Agent ◽  
Immunosuppressive Drugs ◽  
Renal Transplant Recipients ◽  
Mechanically Ventilated ◽  
Risk And Benefit

Severe COVID-19 infection management for a recipient of kidney transplant has debatable prognosis and treatment. We described the case of a COVID-19 infected 70 year old female, previously had renal transplantation in 2017. The patient took immunosuppressive agents as routine drugs for transplant recipient status and received lopinavir/ritonavir, hydroxychloroquine, and dexamethasone daily at the hospitalization. Specific question arises about renal transplant recipients being infected by COVID-19 – whether the infection will get worse compared to those without immunosuppresive agent. In this case, author decided to stop the immunosuppressive agent followed administration of combination lopinavir/ritonavir, hydroxychloroquine, and dexamethasone that gives a good clinical impact change to patient’s condition after once getting worsened and mechanically ventilated. Nevertheless, the assessment of risk and benefit in continuing immunosuppressive drugs is concurrently essential due to the prevention of transplant rejection.

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