scholarly journals Immunopathogenesis and Cellular Interactions in Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis

2020 ◽  
Vol 11 ◽  
Author(s):  
Sepehr Aghajanian ◽  
Majid Teymoori-Rad ◽  
Ghazale Molaverdi ◽  
Sayed-Hamidreza Mozhgani
Keyword(s):  
Leukemia Virus ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Cellular Interactions ◽  
Limb Weakness ◽  
Cell Leukemia Virus Type ◽  
T Lymphotropic Virus ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Sensory Disturbances

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neuropathological disorder in 1–3% of individuals infected with Human T-lymphotropic virus 1 (HTLV-1). This condition is characterized by progressive spastic lower limb weakness and paralysis, lower back pain, bladder incontinence, and mild sensory disturbances resembling spinal forms of multiple sclerosis. This disease also causes chronic disability and is therefore associated with high health burden in areas where HTLV-1 infection is endemic. Despite various efforts in understanding the virus and discovery of novel diagnostic markers, and cellular and viral interactions, HAM/TSP management is still unsatisfactory and mainly focused on symptomatic alleviation, and it hasn’t been explained why only a minority of the virus carriers develop HAM/TSP. This comprehensive review focuses on host and viral factors in association with immunopathology of the disease in hope of providing new insights for drug therapies or other forms of intervention.

A search for human T-cell leukemia virus type I in the lesions of patients with tropical spastic paraparesis and polymyositis

1995 ◽  
Vol 38 (3) ◽  
pp. 454-460 ◽  
Author(s):  
Fr�d�ric Tangy ◽  
Jean-Claude Vernant ◽  
Laurent Coscoy ◽  
Marl�ne Ossondo ◽  
R�Mi Bellance ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Molecular characterization of human T-cell leukemia virus type 1 gp46 glycoprotein from healthy carriers and tropical spastic paraparesis/HTLV-associated myelopathy infected individuals

Retrovirology ◽  
2014 ◽  
Vol 11 (Suppl 1) ◽  
pp. P83
Author(s):  
Aline CA Mota-Miranda ◽  
Fernanda K Barreto ◽  
Maria FC Amarante ◽  
Everton Baptista ◽  
Joana P Monteiro-Cunha ◽  
...  
Keyword(s):  
T Cell ◽  
Leukemia Virus ◽  
Spastic Paraparesis ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Healthy Carriers

scholarly journals Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Recent Perspectives

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Mineki Saito ◽  
Charles R. M. Bangham
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Spastic Paraparesis ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

Human T-cell leukemia virus type-1 (HTLV-1) is a replication-competent human retrovirus associated with two distinct types of disease only in a minority of infected individuals: the malignancy known as adult T-cell leukemia (ATL) and a chronic inflammatory central nervous system disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is a chronic progressive myelopathy characterized by spastic paraparesis, sphincter dysfunction, and mild sensory disturbance in the lower extremities. Although the factors that cause these different manifestations of HTLV-1 infection are not fully understood, accumulating evidence from host population genetics, viral genetics, DNA expression microarrays, and assays of lymphocyte function suggests that complex virus-host interactions and the host immune response play an important role in the pathogenesis of HAM/TSP. Especially, the efficiency of an individual's cytotoxic T-cell (CTL) response to HTLV-1 limits the HTLV-1 proviral load and the risk of HAM/TSP. This paper focuses on the recent advances in HAM/TSP research with the aim to identify the precise mechanisms of disease, in order to develop effective treatment and prevention.

scholarly journals Progressive Spastic Paraparesis Associated with Human T-Cell Leukemia Virus Type I(HTLV-I).

1992 ◽  
Vol 31 (11) ◽  
pp. 1257-1261 ◽  
Author(s):  
Luis CARTIER ◽  
Fernando ARAYA ◽  
Jose Luis CASTILLO ◽  
Fernando RUIZ ◽  
Adriana GORMAZ ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Spastic Paraparesis ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus
Sign in / Sign up

Export Citation Format

Share Document