scholarly journals Progressive Prefrontal Cortex Dysfunction in Parkinson's Disease With Probable REM Sleep Behavior Disorder: A 3-Year Longitudinal Study

2022 ◽  
Vol 13 ◽  
Author(s):  
Xiuqin Jia ◽  
Wentao Fan ◽  
Zhijiang Wang ◽  
Yuehong Liu ◽  
Ying Li ◽  
...  

This study aimed to explore the disrupted prefrontal cortex activity specific to patients with Parkinson's disease (PD) with rapid eye movement sleep behavior disorder (RBD) compared with those without and to further examine the associations between these alterations and neuropsychological measurements. Ninety-six patients with early PD underwent both structural and functional MRI, and also neuropsychological assessments in the Parkinson's Progression Markers Initiative (PPMI) database. Of these, 46 patients who completed 1- and 3-year fMRI follow-up examinations were categorized as PD with probable RBD (PD-pRBD+) and without (PD-pRBD−). The left dorsolateral prefrontal cortex (DLPFC) seed-to-voxel functional connectivity analysis was conducted to evaluate the progressive neural alterations specific to PD-pRBD+ compared with PD-pRBD− over time. Furthermore, relationships between these alterations and neuropsychological performance were examined. Compared with patients with PD-pRBD−, patients with PD-pRBD+ initially exhibited connectivity deficits between the left DLPFC and the medial frontopolar cortex. Moreover, these patients further exhibited disrupted DLPFC connectivity in the lateral frontopolar cortex at the 3-year follow-up evaluation. Correlation analysis revealed that connectivity between the left DLPFC and frontopolar cortex was positively related to executive function in PD-pRBD+ after adjusting for nuisance variables. Progressive prefrontal cortex dysfunction associated with RBD in early PD may provide an effective subtype-specific biomarker of neurodegenerative progression, which may shed light on the neuropathological mechanisms underlying the clinical heterogeneity of this disease.

2021 ◽  
Author(s):  
Milan Nigam ◽  
Ines Ayadi ◽  
Camille Noiray ◽  
Ana Catarina Branquino‐Bras ◽  
Erika Herraez Sanchez ◽  
...  

2016 ◽  
Vol 21 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Mina Ansari ◽  
Farzaneh Rahmani ◽  
Mahsa Dolatshahi ◽  
Atefe Pooyan ◽  
Mohammad Hadi Aarabi

2013 ◽  
Vol 18 (2) ◽  
pp. 319-323 ◽  
Author(s):  
Raffaele Ferri ◽  
Filomena I. I. Cosentino ◽  
Fabio Pizza ◽  
Debora Aricò ◽  
Giuseppe Plazzi

2005 ◽  
Vol 21 (4) ◽  
pp. 462-466 ◽  
Author(s):  
Elena Sinforiani ◽  
Roberta Zangaglia ◽  
Raffaele Manni ◽  
Silvano Cristina ◽  
Enrico Marchioni ◽  
...  

2018 ◽  
Vol 17 (1) ◽  
pp. 113-122 ◽  
Author(s):  
Manoel Alves Sobreira-Neto ◽  
Márcio Alexandre Pena-Pereira ◽  
Emmanuelle Silva Tavares Sobreira ◽  
Marcos Hortes Nisihara Chagas ◽  
Carlos Maurício Oliveira de Almeida ◽  
...  

2015 ◽  
Vol 16 (1) ◽  
pp. 186-189 ◽  
Author(s):  
Karin Stiasny-Kolster ◽  
Friederike Sixel-Döring ◽  
Claudia Trenkwalder ◽  
Monika Heinzel-Gutenbrunner ◽  
Klaus Seppi ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document