Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

The differential contribution of the inner hair cells (IHC) and the outer hair cells (OHC) in the mammalian cochlea to hearing sensitivity was assessed in six behaviorally-trained guinea pigs by comparing audiograms preadministration and postadministration of kanamycin, an antibiotic that predominantly destroys guinea pig OHC while leaving the IHC structurally unchanged. The results support the hypothesis that only the IHC of the cochlea responds to tones approximately 50 to 60 dB above the threshold of the intact cochlea.

Download Full-text

Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear

The Journal of Comparative Neurology ◽

10.1002/cne.903550307 ◽

1995 ◽

Vol 355 (3) ◽

pp. 405-417 ◽

Cited By ~ 109

Author(s):

Lin Li ◽

Graham Nevill ◽

Andy Forge

Keyword(s):

Guinea Pig ◽

Hair Cell ◽

Inner Ear ◽

Cell Loss ◽

Hair Cell Loss ◽

Sensory Epithelia ◽

Vestibular Sensory Epithelia

Download Full-text

Quercetin protects against hair cell loss in the zebrafish lateral line and guinea pig cochlea

Hearing Research ◽

10.1016/j.heares.2016.10.001 ◽

2016 ◽

Vol 342 ◽

pp. 80-85 ◽

Cited By ~ 5

Author(s):

Yoshinobu Hirose ◽

Kazuma Sugahara ◽

Eiju Kanagawa ◽

Yousuke Takemoto ◽

Makoto Hashimoto ◽

...

Keyword(s):

Guinea Pig ◽

Hair Cell ◽

Lateral Line ◽

Cell Loss ◽

Hair Cell Loss ◽

Guinea Pig Cochlea

Download Full-text

Chronic Perilymphatic Fistula: Experimental Model in the Guinea Pig

Otolaryngology ◽

10.1177/019459988809900405 ◽

1988 ◽

Vol 99 (4) ◽

pp. 380-388 ◽

Cited By ~ 6

Author(s):

Paul Flint ◽

Larry G. Duckert ◽

Robert A. Dobie ◽

Edwin W. Rubel

Keyword(s):

Guinea Pig ◽

Hair Cell ◽

Round Window ◽

Cell Loss ◽

Hair Cell Loss ◽

Scala Tympani ◽

Rubber Tubing ◽

Perilymphatic Fistula ◽

Similar Threshold ◽

Baseline Levels

Chronic perilymphatic fistulas were created in guinea pig cochleas using silicone rubber tubing placed into the scala tympani through the round window. Fistula patency was determined by fluorescein perfusion into cerebral spinal fluid. Fistulas were found to be patent in 6 of 6 animals at 7 days and 8 of 13 animals at 28 days. Analysis of ABRs revealed threshold increases of 10 to 15 dB across all frequencies at 1 hour and 7 days. However, thresholds returned to pre-fistula levels by 28 days. Animals with acute fistulas (simple laceration of the round window) had similar threshold increases at 1 hour; however, recovery to baseline levels occurred by day 7. Control animals with intact round windows did not have threshold shifts. Scanning electron microscopy revealed hair cell loss localized to the apical and basal turns of the cochlea. The morphologic changes observed occurred acutely (within 7 days) and were not progressive, despite the presence of a fistula. Hair cell loss or degeneration did not correlate with hearing loss.

Download Full-text