scholarly journals Short-Term Sustained Hypoxia Elevates Basal and Hypoxia-Induced Ventilation but Not the Carotid Body Chemoreceptor Activity in Rats

2018 ◽  
Vol 9 ◽  
Author(s):  
Karine C. Flor ◽  
Elaine F. Silva ◽  
Miguel F. Menezes ◽  
Gustavo R. Pedrino ◽  
Eduardo Colombari ◽  
...  
Keyword(s):  
Carotid Body ◽  
Short Term ◽  
Sustained Hypoxia

Chronic Caffeine Intake in Adult Rat Inhibits Carotid Body Sensitization Produced by Chronic Sustained Hypoxia but Maintains Intact Chemoreflex Output

2012 ◽  
Vol 82 (6) ◽  
pp. 1056-1065 ◽  
Author(s):  
Silvia V. Conde ◽  
Maria J. Ribeiro ◽  
Ana Obeso ◽  
Ricardo Rigual ◽  
Emilia C. Monteiro ◽  
...  
Keyword(s):  
Carotid Body ◽  
Caffeine Intake ◽  
Adult Rat ◽  
Chronic Caffeine ◽  
Sustained Hypoxia

Influence of reduced carotid body drive during sustained hypoxia on hypoxic depression of ventilation in humans

1996 ◽  
Vol 81 (2) ◽  
pp. 565-572 ◽  
Author(s):  
A. Dahan ◽  
D. Ward ◽  
M. van den Elsen ◽  
J. Temp ◽  
A. Berkenbosch
Keyword(s):  
Carotid Body ◽  
Hypoxic Exposure ◽  
Hypoxic Response ◽  
Air Breathing ◽  
Carotid Bodies ◽  
Delayed Recovery ◽  
End Tidal ◽  
Second Period ◽  
Sustained Hypoxia

To evaluate whether the intact hypoxic drive from the carotid bodies during sustained hypoxia is required for the generation of hypoxic depression of ventilation (VE), 16 volunteers were exposed to two consecutive periods of isocapnic hypoxia (first period 20 min; second period 5 min; end-tidal PO2 45 Torr) separated by 6 min of normoxia. In study A, saline was given. In study B, 3 micrograms.kg-1.min-1 i.v. dopamine (DA), a carotid body inhibitor, was given during the first hypoxic exposure followed by saline during normoxia and the second hypoxic exposure. In study C, 20 min of normoxia with DA preceded 6 min of normoxia and 5 min of hypoxia without DA. The first peak hypoxic VE (PHV) in study A was approximately 100% above normoxic VE. After 20 min of hypoxia, VE declined to 60% above normoxic VE. The second PHV in study A was only 60% of the first PHV. We relate this delayed recovery from hypoxia to "ongoing" effects of hypoxic depression. During DA infusion, the changes in VE due to sustained hypoxia were insignificant (study B). The second PHV in study B was not different from the PHV after air breathing in studies A and C. This indicates that the recovery from sustained hypoxia with a suppressed carotid body drive was complete within 6 min. Our results show that despite central hypoxia the absence of ventilatory changes during 20 min of isocapnic hypoxia due to intravenous DA prevented the generation of central hypoxic depression and the depression of a subsequent hypoxic response.

Distinct cardiovascular and respiratory responses to short-term sustained hypoxia in juvenile Sprague Dawley and Wistar Hannover rats

2021 ◽  
Vol 230 ◽  
pp. 102746 ◽  
Author(s):  
Darlan S. Bazilio ◽  
Karla L. Rodrigues ◽  
Davi J.A. Moraes ◽  
Benedito H. Machado
Keyword(s):  
Sprague Dawley ◽  
Short Term ◽  
Sustained Hypoxia ◽  
Respiratory Responses

scholarly journals Differences in tyrosine hydroxylase expression after short-term hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body

2010 ◽  
Vol 173 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Jun Wakai ◽  
Keiichiro Kizaki ◽  
Misuzu Yamaguchi-Yamada ◽  
Yoshio Yamamoto
Keyword(s):  
Tyrosine Hydroxylase ◽  
Carotid Body ◽  
Short Term ◽  
Hypercapnic Hypoxia

scholarly journals Enhanced Firing in NTS Induced by Short-Term Sustained Hypoxia Is Modulated by Glia-Neuron Interaction

2015 ◽  
Vol 35 (17) ◽  
pp. 6903-6917 ◽  
Author(s):  
D. Accorsi-Mendonca ◽  
C. E. L. Almado ◽  
L. G. H. Bonagamba ◽  
J. A. Castania ◽  
D. J. A. Moraes ◽  
...  
Keyword(s):  
Short Term ◽  
Neuron Interaction ◽  
Sustained Hypoxia

scholarly journals Inhibitory control of active expiration by the Bötzinger complex in rats

2019 ◽  
Author(s):  
Karine C. Flor ◽  
William H. Barnett ◽  
Marlusa Karlen-Amarante ◽  
Yaroslav Molkov ◽  
Daniel B. Zoccal
Keyword(s):  
Short Term ◽  
Inhibitory Circuitry ◽  
Respiratory Network ◽  
Bötzinger Complex ◽  
Expiratory Neurons ◽  
Parafacial Respiratory Group ◽  
And Control ◽  
Pharmacological Manipulations ◽  
Sustained Hypoxia

ABSTRACTThe expiratory neurons of the Bötzinger complex (BötC) provide inhibitory inputs to the respiratory network, which, during eupnea, are critically important for respiratory phase transition and duration control. Herein, we investigated how the BötC neurons interact with the expiratory oscillator located in the parafacial respiratory group (pFRG) and control the abdominal activity during active expiration. Using the decerebrated, arterially perfused in situ rat preparations, we recorded the neuronal activity and performed pharmacological manipulations of the BötC and pFRG during hypercapnia or after the exposure to short-term sustained hypoxia – conditions that generate active expiration. The experimental data were integrated in a mathematical model to gain new insights in the inhibitory connectome within the respiratory central pattern generator. Our results reveal a complex inhibitory circuitry within the BötC that provides inhibitory inputs to the pFRG thus restraining abdominal activity under resting conditions and contributing to abdominal expiratory pattern formation during active expiration.

scholarly journals Changes in the autonomic and respiratory patterns of mice submitted to short‐term sustained hypoxia

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Karla Rodrigues ◽  
Juliana Souza ◽  
Darlan Bazilio ◽  
Mauro Oliveira ◽  
Melina Silva ◽  
...  
Keyword(s):  
Short Term ◽  
Sustained Hypoxia

scholarly journals Short-term Hypoxia Transiently Increases Dopamine β-Hydroxylase Immunoreactivity in Glomus Cells of the Rat Carotid Body

2012 ◽  
Vol 61 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Kouki Kato ◽  
Takuya Yokoyama ◽  
Misuzu Yamaguchi-Yamada ◽  
Yoshio Yamamoto
Keyword(s):  
Carotid Body ◽  
Short Term ◽  
Glomus Cells

scholarly journals Short-term Hypoxia Increases Tyrosine Hydroxylase Immunoreactivity in Rat Carotid Body

2010 ◽  
Vol 58 (9) ◽  
pp. 839-846 ◽  
Author(s):  
Kouki Kato ◽  
Misuzu Yamaguchi-Yamada ◽  
Yoshio Yamamoto
Keyword(s):  
Tyrosine Hydroxylase ◽  
Carotid Body ◽  
Short Term

Inhibitory sympathetic action on the carotid body responses to sustained hypoxia

1994 ◽  
Vol 95 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Nandri R. Prabhakar ◽  
Yu Ru Kou
Keyword(s):  
Carotid Body ◽  
Sustained Hypoxia
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