Editorial: The Integrative Physiology of Metabolic Downstates

A computerized system is described, combining automatic collection of urine in short intervals (minutes) over long periods (days) and recordings of body temperature, MABP, and heart rate in chronically instrumented conscious dogs. During the studies the dogs are housed in metabolic cages. Indwelling catheters and electrical wires are connected to a specially designed swivel and directed out of the cage to the next room. Infusions, blood sampling, and monitoring can be performed from this room without disturbance to the dogs. Three examples of recordings are given. In one of these examples the sodium excretion patterns on 5 consecutive days under continuous saline infusion in one dog is evaluated. Urine was collected every 20 min. Sodium excretion showed cyclic variations. Fourier analysis exhibited 18-h periods and 4- to 8-h periods. The described system renders, e.g., coherent time series analysis possible for a variety of simultaneously recorded physiological variables and may thus acquire considerable importance for integrative physiology.

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Integrative physiology, functional genomics and the phenotype gap: a guide for comparative physiologists

Journal of Experimental Biology ◽

10.1242/jeb.002691 ◽

2007 ◽

Vol 210 (9) ◽

pp. 1632-1640 ◽

Cited By ~ 25

Author(s):

J. A. T. Dow

Keyword(s):

Functional Genomics ◽

Integrative Physiology

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Cellular Responses and Integrative Physiology

Drug Development Research ◽

10.1002/(sici)1098-2299(199801)43:1<35::aid-ddr4>3.0.co;2-r ◽

1998 ◽

Vol 43 (1) ◽

pp. 35-44

Keyword(s):

Cellular Responses ◽

Integrative Physiology

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Integrative physiology: some texts and methods of integrative study.

AJP Advances in Physiology Education ◽

10.1152/advances.1995.269.6.s55 ◽

1995 ◽

Vol 269 (6) ◽

pp. S55

Author(s):

J Engelberg

Keyword(s):

Conceptual Frameworks ◽

Case Histories ◽

Integrative Physiology ◽

Integrative Study ◽

Living Being

The development of the integrative dimensions of physiology will require texts and forms of study that differ from those to which we have become accustomed in the areas of specialization. The following two types of texts lie at the heart of integrative study: framework statements and case histories. Framework statements are scientific aphorisms that summarize integrative insights; ordered chains of these statements form conceptual frameworks that stimulate integrative dialogue and thought. Case histories are stories that portray the events in the life of a living being, generally human. The nature of these texts, how framework statements are created, and methods of how texts of this kind may be used in group dialogues are discussed.

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