Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study

Background: Habituation is considered to have protective and filtering mechanisms. The present study is aim to find the casual relationship and mechanisms of excitatory–inhibitory (E/I) dysfunctions in schizophrenia (SCZ) via habituation.Methods: A dichotic listening paradigm was performed with simultaneous EEG recording on 22 schizophrenia patients and 22 gender- and age-matched healthy controls. Source reconstruction and dynamic causal modeling (DCM) analysis were performed to estimate the effective connectivity and casual relationship between frontal and temporal regions before and after habituation.Results: The schizophrenia patients expressed later habituation onset (p < 0.01) and hyper-activity in both lateral frontal–temporal cortices than controls (p = 0.001). The patients also showed decreased top-down and bottom-up connectivity in bilateral frontal–temporal regions (p < 0.01). The contralateral frontal–frontal and temporal–temporal connectivity showed a left to right decreasing (p < 0.01) and right to left strengthening (p < 0.01).Conclusions: The results give causal evidence for E/I imbalance in schizophrenia during dichotic auditory processing. The altered effective connectivity in frontal–temporal circuit could represent the trait bio-marker of schizophrenia with auditory hallucinations.

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Counteracting Effect of Glutathione on the Glutamate-Driven Excitation/Inhibition Imbalance in First-Episode Schizophrenia: A 7T Mrs and Dynamic Causal Modeling Study

Biological Psychiatry ◽

10.1016/j.biopsych.2021.02.704 ◽

2021 ◽

Vol 89 (9) ◽

pp. S282

Author(s):

Roberto Limongi ◽

Peter Jeon ◽

Jean Theberge ◽

Lena Palaniyappan

Keyword(s):

Causal Modeling ◽

First Episode ◽

Dynamic Causal Modeling ◽

First Episode Schizophrenia ◽

Modeling Study

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The Side Effect of Haloperidol in Schizophrenic Patients: Analysis of Red Blood Cell Distribution Width (RDW) and Mean Platelet Volume (MPV) Values

Global Journal of Health Science ◽

10.5539/gjhs.v11n2p55 ◽

2019 ◽

Vol 11 (2) ◽

pp. 55

Author(s):

Andi Jayalangkara Tanra ◽

Hawaidah Hawaidah ◽

Yazzit Mahri ◽

Saidah Syamsuddin ◽

Andi Nilawati Usman ◽

...

Keyword(s):

Side Effect ◽

First Episode ◽

Distribution Width ◽

Before And After ◽

Icd 10 ◽

Schizophrenic Patients ◽

Haloperidol Treatment ◽

Analytic Design ◽

First Episode Schizophrenia ◽

Haloperidol Group

INTRODUCTION: Like the increase of pro-inflammatory cytokines and oxidative stress as schizophrenia pathophysiology, haloperidol also increases RDW and MPV values. Both of these values have been clinicians concern because they are a risk factor for the various type of vascular disease. OBJECTIVE: This study aims to determine the side effect of haloperidol on RDW and MPV values in schizophrenic patients. METHODS: This research method uses observational analytic design with a prospective cohort approach with pre and posts analysis conducted at the Regional Special Hospital of South Sulawesi Province during May - July 2018 in 30 schizophrenic subjects. The subjects were diagnosed as first episode schizophrenia based on ICD 10, blood samples were taken, for RDW and MPV values before and after haloperidol was given at the 4th and 8th weeks. RESULTS: The results showed that the mean RDW value at the 4th week was higher in 15 mg/day haloperidol group (15.8) compared to 7.5 mg/day haloperidol group (15.3) with p<0.05. Mean RDW value taken at 8th week was higher in 15 mg/day haloperidol group (16.4) compared to 7.5 mg/day haloperidol group (15.6) with p<0.001. Mean MPV value taken at 8th week was higher in 15 mg/day haloperidol group (13.3) compared to 7.5 mg/day haloperidol group (11.6) with p<0.001. CONCLUSION: This study showed an increase in the RDW value in schizophrenia subjects prior to the haloperidol administration. RDW and MPV values were higher after haloperidol treatment compares to before haloperidol treatment. The increase of RDW and MPV values tend to be influenced by haloperidol dosage and administration duration.

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A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia

Schizophrenia Research ◽

10.1016/j.schres.2004.09.025 ◽

2005 ◽

Vol 75 (2-3) ◽

pp. 247-263 ◽

Cited By ~ 92

Author(s):

Kristine Boksman ◽

Jean Théberge ◽

Peter Williamson ◽

Dick J. Drost ◽

Ashok Malla ◽

...

Keyword(s):

Brain Connectivity ◽

First Episode ◽

Word Fluency ◽

Fmri Study ◽

First Episode Schizophrenia

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Childhood traumatic events and types of auditory verbal hallucinations in first-episode schizophrenia patients

Comprehensive Psychiatry ◽

10.1016/j.comppsych.2015.12.003 ◽

2016 ◽

Vol 66 ◽

pp. 17-22 ◽

Cited By ~ 21

Author(s):

Błażej Misiak ◽

Ahmed A. Moustafa ◽

Andrzej Kiejna ◽

Dorota Frydecka

Keyword(s):

Traumatic Events ◽

First Episode ◽

Auditory Verbal Hallucinations ◽

First Episode Schizophrenia

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Putamen-related regional and network functional deficits in first-episode schizophrenia with auditory verbal hallucinations

Schizophrenia Research ◽

10.1016/j.schres.2016.02.039 ◽

2016 ◽

Vol 173 (1-2) ◽

pp. 13-22 ◽

Cited By ~ 51

Author(s):

Long-Biao Cui ◽

Kang Liu ◽

Chen Li ◽

Liu-Xian Wang ◽

Fan Guo ◽

...

Keyword(s):

First Episode ◽

Auditory Verbal Hallucinations ◽

Functional Deficits ◽

First Episode Schizophrenia

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Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia

10.1101/19012773 ◽

2019 ◽

Author(s):

Martin J. Dietz ◽

Yuan Zhou ◽

Lotte Veddum ◽

Christopher D. Frith ◽

Vibeke F. Bliksted

Keyword(s):

Social Cognition ◽

Negative Symptoms ◽

Effective Connectivity ◽

Predictive Coding ◽

First Episode ◽

Positive Symptoms ◽

Prediction Errors ◽

Social Stimuli ◽

Human Connectome Project ◽

First Episode Schizophrenia

AbstractSchizophrenia is a tenacious psychiatric disorder thought to result from synaptic dysfunction. While symptomatology is traditionally divided into positive and negative symptoms, abnormal social cognition is now recognized a key component of schizophrenia. Nonetheless, we are still lacking a mechanistic understanding of how aberrant synaptic connectivity is expressed in schizophrenia during social perception and how it relates to positive and negative symptomatology. We used fMRI and dynamic causal modelling (DCM) to test for abnormalities in synaptic efficacy in twenty-four patients with first-episode schizophrenia (FES) compared to twenty-five matched controls performing the Human Connectome Project (HCP) social cognition paradigm. Patients had not received regular therapeutic antipsychotics, but were not completely drug naïve. Our data reveal an increase in excitatory feedforward connectivity from motion-sensitive V5 to posterior superior temporal sulcus (pSTS) in patients compared to matched controls. At the same time, were less accurate than controls in judging social stimuli from non-social stimuli. Crucially, patients with a higher degree of positive symptoms had more disinhibition within pSTS, a region computationally involved in Theory of Mind. We interpret these within a predictive coding framework where increased feedforward connectivity may encode aberrant prediction errors from V5 to hierarchically higher pSTS and local disinhibition within pSTS may reflect aberrant encoding of the precision of cortical representations about social stimuli.

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