scholarly journals Therapeutic Target Discovery Using High-Throughput Genetic Screens in Acute Myeloid Leukemia

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1888
Author(s):  
Qiao Liu ◽  
Michelle Garcia ◽  
Shaoyuan Wang ◽  
Chun-Wei Chen
Keyword(s):  
Acute Myeloid Leukemia ◽  
High Throughput ◽  
Myeloid Leukemia ◽  
Therapeutic Strategies ◽  
Genetic Screens ◽  
Hairpin Rna ◽  
Effector Genes ◽  
Cellular Pathways ◽  
Acute Myeloid

The development of high-throughput gene manipulating tools such as short hairpin RNA (shRNA) and CRISPR/Cas9 libraries has enabled robust characterization of novel functional genes contributing to the pathological states of the diseases. In acute myeloid leukemia (AML), these genetic screen approaches have been used to identify effector genes with previously unknown roles in AML. These AML-related genes centralize alongside the cellular pathways mediating epigenetics, signaling transduction, transcriptional regulation, and energy metabolism. The shRNA/CRISPR genetic screens also realized an array of candidate genes amenable to pharmaceutical targeting. This review aims to summarize genes, mechanisms, and potential therapeutic strategies found via high-throughput genetic screens in AML. We also discuss the potential of these findings to instruct novel AML therapies for combating drug resistance in this genetically heterogeneous disease.

scholarly journals Development and characterization of a novel flavopiridol formulation for treatment of acute myeloid leukemia

2021 ◽  
Author(s):  
Kent T.J. Chen ◽  
Gardenia G.C. Militao ◽  
Malathi Anantha ◽  
Dominik Witzigmann ◽  
Ada W.Y. Leung ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Acute Myeloid

Cytogenomic characterization of double minute heterogeneity in therapy related acute myeloid leukemia

2019 ◽  
Vol 238 ◽  
pp. 69-75 ◽  
Author(s):  
Prasad Koduru ◽  
Weina Chen ◽  
Barbara Haley ◽  
Kevin Ho ◽  
Dwight Oliver ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Double Minute ◽  
Acute Myeloid

272 Morphologic and phenotypic characterization of paediatric secondary acute myeloid leukemia (sAML)

2011 ◽  
Vol 35 ◽  
pp. S107
Author(s):  
S. Francescato ◽  
B. Buldini ◽  
M. Veltroni ◽  
M. Zecca ◽  
S. Fenu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Phenotypic Characterization ◽  
Secondary Acute Myeloid Leukemia ◽  
Acute Myeloid

Characterization of acute myeloid leukemia with del(9q) – Impact of the genes in the minimally deleted region

2019 ◽  
Vol 76 ◽  
pp. 15-23 ◽  
Author(s):  
Isabel S. Naarmann-de Vries ◽  
Yvonne Sackmann ◽  
Felicitas Klein ◽  
Antje Ostareck-Lederer ◽  
Dirk H. Ostareck ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Characterization of TRKA signaling in acute myeloid leukemia

Oncotarget ◽  
2018 ◽  
Vol 9 (53) ◽  
pp. 30092-30105 ◽  
Author(s):  
Shelley M. Herbrich ◽  
Sankaranarayanan Kannan ◽  
Riitta M. Nolo ◽  
Marisa Hornbaker ◽  
Joya Chandra ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia

2020 ◽  
Vol 19 (9) ◽  
pp. 1875-1888
Author(s):  
Bettina Brauchle ◽  
Rebecca L. Goldstein ◽  
Christine M. Karbowski ◽  
Anja Henn ◽  
Chi-Ming Li ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Acute Myeloid
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