Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study

Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after liver transplantation remaining under constant care of the Department of Pediatric Surgery and Organ Transplantation. The analysis included several tests: estimated glomerular function (eGFR), results of screening for renal tubular defects and blood concentrations of basic immunosuppressive drug-tacrolimus. CKD was diagnosed in 3% of children at 12 years after LT. The maintaining of tacrolimus concentrations >4 ng/mL in long-term observation was associated with a significant increase of microalbuminuria. The presence of microalbuminuria, regarded as a risk factor of CKD, confirmed the necessity of regular comprehensive assessment of patients in long-term follow-up.

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LONG-TERM FOLLOW-UP OF ACITVE IMMUNIZATION AGAINST DE NOVO HEPATITIS B VIRUS INFECTION IN PEDIATRIC PATIENTS AFTER LIVER TRANSPLANTATION

Transplantation Journal ◽

10.1097/00007890-200407271-00111 ◽

2004 ◽

Vol 78 ◽

pp. 38

Author(s):

K S. Suh ◽

N J. Yi ◽

C H. Kwon ◽

J H. Cho ◽

K U. Lee

Keyword(s):

Liver Transplantation ◽

Hepatitis B Virus ◽

Pediatric Patients ◽

De Novo ◽

Hepatitis B Virus Infection ◽

B Virus ◽

Long Term Follow Up ◽

De Novo Hepatitis B

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Long-Term Outcome after Liver Transplantation for Progressive Familial Intrahepatic Cholestasis

Medicina ◽

10.3390/medicina57080854 ◽

2021 ◽

Vol 57 (8) ◽

pp. 854

Author(s):

Safak Gül-Klein ◽

Robert Öllinger ◽

Moritz Schmelzle ◽

Johann Pratschke ◽

Wenzel Schöning

Keyword(s):

Liver Transplantation ◽

Liver Function ◽

Intrahepatic Cholestasis ◽

Pediatric Patients ◽

Extrahepatic Manifestations ◽

Long Term Outcome ◽

Progressive Familial Intrahepatic Cholestasis ◽

Long Term Follow Up

Background and Objectives: Progressive familial intrahepatic cholestasis (PFIC) is a rare autosomal recessive inherited disease divided into five types (PFIC 1-5). Characteristic of all types is early disease onset, which may result clinically in portal hypertension, fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and extrahepatic manifestations. Liver transplantation (LT) is the only successful treatment approach. Our aim is to present the good long-term outcomes after liver transplantation for PFIC1, focusing on liver function as well as the occurrence of extrahepatic manifestation after liver transplantation. Materials and Methods: A total of seven pediatric patients with PFIC1 underwent liver transplantation between January 1999 and September 2019 at the Department of Surgery, Charité Campus Virchow Klinikum and Charité Campus Mitte of Charité-Universitätsmedizin Berlin. Long-term follow-up data were collected on all patients, specifically considering liver function and extrahepatic manifestations. Results: Seven (3.2%) recipients were found from a cohort of 219 pediatric patients. Two of the seven patients had multilocular HCC in cirrhosis. Disease recurrence or graft loss did not occur in any patient. Two patients (male, siblings) had persistently elevated liver parameters but showed excellent liver function. Patient and graft survival during long-term follow-up was 100%, and no severe extrahepatic manifestations requiring hospitalization or surgery occurred. We noted a low complication rate during long-term follow-up and excellent patient outcome. Conclusions: PFIC1 long-term follow-up after LT shows promising results for this rare disease. In particular, the clinical relevance of extrahepatic manifestations seems acceptable, and graft function seems to be barely affected. Further multicenter studies are needed to analyze the clinically inhomogeneous presentation and to better understand the courses after LT.

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Successful treatment of hepatitis C reinfection with interferon-alpha2b and ribavirin after liver transplantation. A long-term follow-up.

Liver International ◽

10.1111/j.1478-3231.2005.1065.x ◽

2005 ◽

Vol 25 (4) ◽

pp. 717-722 ◽

Cited By ~ 18

Author(s):

Suleyman Yedibela ◽

Detlef Schuppan ◽

Volker Muller ◽

Vera Schellerer ◽

Andrea Tannapfel ◽

...

Keyword(s):

Liver Transplantation ◽

Hepatitis C ◽

Successful Treatment ◽

Long Term Follow Up ◽

Hepatitis C Reinfection

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Mid- to long-term follow-up of pediatric patients with coronary artery fistula

Journal of the Formosan Medical Association ◽

10.1016/j.jfma.2015.05.015 ◽

2016 ◽

Vol 115 (7) ◽

pp. 571-576 ◽

Cited By ~ 9

Author(s):

Mao-Hung Lo ◽

I-Chun Lin ◽

Kai-Sheng Hsieh ◽

Chien-Fu Huang ◽

Shao-Ju Chien ◽

...

Keyword(s):

Coronary Artery ◽

Pediatric Patients ◽

Coronary Artery Fistula ◽

Long Term Follow Up

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Long-term follow-up of portopulmonary hypertension patients after liver transplantation

Liver Transplantation ◽

10.1002/lt.23870 ◽

2014 ◽

Vol 20 (6) ◽

pp. 724-727 ◽

Cited By ~ 46

Author(s):

Saira Khaderi ◽

Rashid Khan ◽

Zeenath Safdar ◽

Rise Stribling ◽

John M. Vierling ◽

...

Keyword(s):

Liver Transplantation ◽

Portopulmonary Hypertension ◽

Long Term Follow Up

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Long-term effectiveness and safety of antiepileptic drugs in children and adults

Reviews on Clinical Pharmacology and Drug Therapy ◽

10.17816/rcf192221-228 ◽

2021 ◽

Vol 19 (2) ◽

pp. 221-228

Author(s):

Roza M. Shaimardanova ◽

Rimma G. Gamirova

Keyword(s):

Valproic Acid ◽

Antiepileptic Drugs ◽

Focal Epilepsy ◽

City Hospital ◽

Long Term Follow Up ◽

Short And Long Term ◽

Long Term Observation ◽

Patients With Epilepsy

AIM: To conduct a retrospective comparative analysis of the efficacy and safety of epilepsy therapy with antiepileptic drugs. MATERIALS AND METHODS: The analysis of the treatment of 428 patients with epilepsy at the Childrens City Hospital No. 8 in Kazan, receiving antiepileptic drugs. RESULTS: It was found that valproic acid is more effective in the treatment of idiopathic generalized epilepsies compared to focal epilepsies (p = 0.0006). Valproate and carbamazepine were the most effective in the treatment of focal epilepsy with short- and long-term follow-up. Valproic acid is more effective than topiramate (p = 0.02), oxcarbazepine (p = 0.003), and levetiracetam (p = 0.003) in the treatment of focal epilepsy in short- and long-term follow-up. Carbamazepine is more effective than topiramate (p = 0.01), oxcarbazepine (p = 0.02), and levetiracetam (p = 0.001) in the treatment of focal epilepsy in long-term follow-up. It was revealed that more often they complained about side effects when using carbamazepine (63.2%). Levetiracetam was found to be better tolerated compared to valproate (p = 0.0006) and carbamazepine (p = 0.0006). Topiramate is better tolerated than carbamazepine (p = 0.02) and valproate (p = 0.03). Oxcarbazepine is better tolerated than carbamazepine in women (p = 0.04). CONCLUSIONS: When choosing an antiepileptic drug, it is necessary to be guided by the principle: first the basic, and then the drugs of the next generations, in the future, rely on information about the tolerability of the drug. It is necessary to evaluate the therapeutic effect of antiepileptic drugs with long-term observation, and use the criterion of complete absence of seizures as an indicator of the effectiveness of drugs.

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Endoscopic Transventricular Transaqueductal Magendie and Luschka Foraminoplasty for Hydrocephalus

Neurosurgery ◽

10.1227/neu.0000000000000283 ◽

2013 ◽

Vol 74 (4) ◽

pp. 426-436 ◽

Cited By ~ 15

Author(s):

Jaime Torres-Corzo ◽

Juan Sánchez-Rodríguez ◽

Dominic Cervantes ◽

Roberto Rodríguez-Della Vecchia ◽

Fernando Muruato-Araiza ◽

...

Keyword(s):

Pediatric Patients ◽

Endoscopic Third Ventriculostomy ◽

Outlet Obstruction ◽

Third Ventriculostomy ◽

Alternative Technique ◽

Vp Shunt ◽

Long Term Follow Up ◽

Secondary Causes

ABSTRACT BACKGROUND: Routinely, hydrocephalus related to fourth ventricular outlet obstruction (FVOO) has been managed with ventriculoperitoneal (VP) shunting or endoscopic third ventriculostomy (ETV). Few reports on Magendie foraminoplasty exist, and Luschka foraminoplasty has not been described. OBJECTIVE: To present an alternative technique in the management of FVOO via an endoscopic transventricular transaqueductal Magendie and Luschka foraminoplasty and to discuss the indications, technique, findings, and outcomes. METHODS: Between 1994 and 2011, all patients who underwent endoscopic Magendie and Luschka foraminoplasty were analyzed. RESULTS: A total of 33 Magendie (28) and/or Luschka (5) foraminoplasties were performed in 30 patients. Twenty-three were adult and 7 were pediatric patients. The etiology of the FVOO was divided into primary etiologies (congenital membrane in 5 and atresia in 2) and secondary causes (neurocysticercosis in 14 patients, bacterial meningitis in 9). Fifteen (50%) had previously failed procedures. Intraoperative findings that led to Magendie/Luschka foraminoplasty were ETV not feasible to perform, nonpatent basal subarachnoid space, or primary FVOO. Minor postoperative complications were seen in 3 patients. Only 26 patients had long-term follow-up; 17 (65.3%) of these had clinical improvement and did not require further procedures. Nine (34.7%) did not improve. Eight required another procedure (7 shunts, and 1 endoscopic procedure). One patient died. CONCLUSION: Flexible neuroendoscopic transventricular transforaminal Magendie and Luschka foraminoplasty is feasible and safe. These procedures may prove to be viable alternatives to standard ETV and VP shunt in appropriate patients. Adequate intraoperative assessment of ETV success is necessary to identify patients who will benefit.

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