scholarly journals Are Viral Vectors Any Good for RNAi Antiviral Therapy?

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1189
Author(s):  
Kenneth Lundstrom
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gene Silencing ◽  
Antiviral Therapy ◽  
Virus Replication ◽  
Viral Vectors ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
B Virus ◽  
Short Hairpin

RNA interference (RNAi) represents a novel approach for alternative antiviral therapy. However, issues related to RNA delivery and stability have presented serious obstacles for obtaining good therapeutic efficacy. Viral vectors are capable of efficient delivery of RNAi as short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA). Efficacy in gene silencing for therapeutic applications against viral diseases has been demonstrated in various animal models. Rotavirus (RV) miR-7 can inhibit rotavirus replication by targeting the RV nonstructural protein 5. Viral gene silencing by targeting the RNAi pathway showed efficient suppression of hepatitis B virus replication by adeno-associated virus (AAV)-based delivery of RNAi hepatitis B virus (HBV) cassettes. Hepatitis C virus replication has been targeted by short hairpin RNA molecules expressed from lentivirus vectors. Potentially, RNAi-based approaches could be suitable for antiviral drugs against COVID-19.

Short hairpin RNA induces methylation of hepatitis B virus covalently closed circular DNA in human hepatoma cells

2013 ◽  
Vol 436 (2) ◽  
pp. 152-155 ◽  
Author(s):  
Hyun Kyung Park ◽  
Bo Young Min ◽  
Nam Young Kim ◽  
Eun Sun Jang ◽  
Cheol Min Shin ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatoma Cells ◽  
Short Hairpin Rna ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Hairpin Rna ◽  
Circular Dna ◽  
B Virus ◽  
Short Hairpin

scholarly journals Hepatitis B virus inhibition in mice by lentiviral vector mediated short hairpin RNA

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Lei Deng ◽  
Guoqiang Li ◽  
Lisen Xi ◽  
Aihong Yin ◽  
Yun Gao ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Lentiviral Vector ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Virus Inhibition ◽  
B Virus ◽  
Short Hairpin

scholarly journals 797. Long-Term Inhibition of Hepatitis B Virus in Transgenic Mice by Adeno-Associated Virus- Delivered Short Hairpin RNA

2006 ◽  
Vol 13 ◽  
pp. S309
Author(s):  
Chun-Chi Chen ◽  
Tai-Ming Ko ◽  
Hsin-I Ma ◽  
Hui-Lin Wu ◽  
Xiao Xiao ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Transgenic Mice ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Adeno Associated Virus ◽  
B Virus ◽  
Short Hairpin

scholarly journals Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

2016 ◽  
Vol 8 (9) ◽  
pp. 1082-1098 ◽  
Author(s):  
Thomas Michler ◽  
Stefanie Große ◽  
Stefan Mockenhaupt ◽  
Natalie Röder ◽  
Ferdinand Stückler ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Sense Strand ◽  
B Virus ◽  
Short Hairpin

scholarly journals 118. Inhibition of Hepatitis B Virus Replication In Vivo Following Delivery of Antiviral TALENs With Recombinant Adeno-Associated Viral Vectors

2015 ◽  
Vol 23 ◽  
pp. S49
Author(s):  
Samantha Nicholson ◽  
Buhle Moyo ◽  
Kristie Bloom ◽  
Claudio Mussolino ◽  
Toni Cathomen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Viral Vectors ◽  
B Virus
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