Faculty Opinions recommendation of Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.

2004 ◽  
Author(s):  
Robert Zucker
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Neurons ◽  
Cultured Hippocampal Neurons

scholarly journals Pregnenolone Sulfate Activates NMDA Receptor Channels

2013 ◽  
pp. 731-736 ◽  
Author(s):  
E. ADAMUSOVÁ ◽  
O. CAIS ◽  
V. VYKLICKÝ ◽  
E. KUDOVÁ ◽  
H. CHODOUNSKÁ ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ion Channels ◽  
Nmda Receptor ◽  
Calcium Signaling ◽  
Hippocampal Neurons ◽  
Hek293 Cells ◽  
Independent Effect ◽  
Pregnenolone Sulfate ◽  
Specific Manner ◽  
Cultured Hippocampal Neurons

Pregnenolone sulfate (PS), an endogenously occurring neurosteroid, has been shown to modulate the activity of several neurotransmitter-gated channels, including the NMDA receptor (NMDAR). NMDARs are glutamate-gated ion channels involved in excitatory synaptic transmission, synaptic plasticity, and excitotoxicity. In this study, we analyzed the effects of PS on calcium signaling in cultured hippocampal neurons and HEK293 cells expressing NMDAR. The cells were loaded with the Ca2+ sensor Fura-2. In agreement with previous electrophysiological experiments, PS potentiated the increases in intracellular Ca2+ induced by an exogenous application of glutamate; however, PS also increased intracellular Ca2+ in the absence of exogenous NMDA agonist. The agonist-independent effect of PS was induced in all neurons studied and in HEK293 cells expressing GluN1/GluN2A-B receptors in a neurosteroid-specific manner. We conclude that PS is an endogenous NMDA agonist that activates the GluN1/GluN2A-B receptors.

Deterioration in synaptic plasticity of cultured hippocampal neurons of senescence-accelerated mouse prone8

2004 ◽  
Vol 1260 ◽  
pp. 325-328 ◽  
Author(s):  
Sheng Yang ◽  
Heping Zhang ◽  
Haifa Qiao ◽  
Zhenwei Liu ◽  
Wenxia Zhou ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Neurons ◽  
Senescence Accelerated Mouse ◽  
Cultured Hippocampal Neurons

Electron microscopic 3D-reconstruction of dendritic spines in cultured hippocampal neurons undergoing synaptic plasticity

2008 ◽  
Vol 68 (7) ◽  
pp. 870-876 ◽  
Author(s):  
Wladimir Ovtscharoff ◽  
Menahem Segal ◽  
Miri Goldin ◽  
Carina Helmeke ◽  
Ute Kreher ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
3D Reconstruction ◽  
Dendritic Spines ◽  
Hippocampal Neurons ◽  
Electron Microscopic ◽  
Cultured Hippocampal Neurons
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