Faculty Opinions recommendation of Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.

2008 ◽  
Author(s):  
Lynn Silver
Keyword(s):  
Topoisomerase Inhibitors ◽  
New Class

Targeting IDH Mutations in AML: Wielding the Double-edged Sword of Differentiation

2020 ◽  
Vol 20 (7) ◽  
pp. 490-500 ◽  
Author(s):  
Justin S. Becker ◽  
Amir T. Fathi
Keyword(s):  
Genome Structure ◽  
Cellular Metabolism ◽  
Standard Of Care ◽  
Competitive Inhibitor ◽  
Driver Mutations ◽  
New Class ◽  
Regulatory Enzymes ◽  
Idh Mutations ◽  
Genomic Characterization

The genomic characterization of acute myeloid leukemia (AML) by DNA sequencing has illuminated subclasses of the disease, with distinct driver mutations, that might be responsive to targeted therapies. Approximately 15-23% of AML genomes harbor mutations in one of two isoforms of isocitrate dehydrogenase (IDH1 or IDH2). These enzymes are constitutive mediators of basic cellular metabolism, but their mutated forms in cancer synthesize an abnormal metabolite, 2- hydroxyglutarate, that in turn acts as a competitive inhibitor of multiple gene regulatory enzymes. As a result, leukemic IDH mutations cause changes in genome structure and gene activity, culminating in an arrest of normal myeloid differentiation. These discoveries have motivated the development of a new class of selective small molecules with the ability to inhibit the mutant IDH enzymes while sparing normal cellular metabolism. These agents have shown promising anti-leukemic activity in animal models and early clinical trials, and are now entering Phase 3 study. This review will focus on the growing preclinical and clinical data evaluating IDH inhibitors for the treatment of IDH-mutated AML. These data suggest that inducing cellular differentiation is central to the mechanism of clinical efficacy for IDH inhibitors, while also mediating toxicity for patients who experience IDH Differentiation Syndrome. Ongoing trials are studying the efficacy of IDH inhibitors in combination with other AML therapies, both to evaluate potential synergistic combinations as well as to identify the appropriate place for IDH inhibitors within existing standard-of-care regimens.

scholarly journals Characterization of the Antibiotic Compound No. 70 Produced byStreptomycessp. IMV-70

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Lyudmila P. Trenozhnikova ◽  
Almagul K. Khasenova ◽  
Assya S. Balgimbaeva ◽  
Galina B. Fedorova ◽  
Genrikh S. Katrukha ◽  
...  
Keyword(s):  
Optimal Growth ◽  
Growth Conditions ◽  
Culture Broth ◽  
Producer Strain ◽  
New Class ◽  
New Antibiotics ◽  
Actinomycete Strain ◽  
Main Component

We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified asStreptomycessp. IMV-70. In the process of fermentation, the strainStreptomycesspp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics.

HIGH DIMENSIONAL KNOT GROUPS AND HNN EXTENSIONS OF THE FIBONACCI GROUPS

1998 ◽  
Vol 07 (04) ◽  
pp. 503-508 ◽  
Author(s):  
ANDRZEJ SZCZEPAŃSKI
Keyword(s):  
High Dimensional ◽  
New Class ◽  
Hnn Extensions

We shall present a new class of examples of high dimensional knot groups. All of them are HNN extensions of the Fibonacci groups. We give also some characterization of these groups.

Characterization of a new class of deletions of the D region of the bacteriophage T4 genome

Virology ◽  
1975 ◽  
Vol 64 (1) ◽  
pp. 144-152 ◽  
Author(s):  
Richard E. Depew ◽  
Thomas J. Snopek ◽  
Nicholas R. Cozzarelli
Keyword(s):  
Bacteriophage T4 ◽  
New Class ◽  
D Region

Synthesis and Characterization of a New Class of Benzothiazolines

2005 ◽  
Vol 180 (1) ◽  
pp. 141-148 ◽  
Author(s):  
Y. P. Singh ◽  
D. Shanker ◽  
R. K. Sharma ◽  
J. Sharma ◽  
A. K. Rai
Keyword(s):  
Synthesis And Characterization ◽  
New Class

scholarly journals Enzymatic synthesis and characterization of novel terpolymers from renewable sources

2019 ◽  
Vol 91 (3) ◽  
pp. 397-408
Author(s):  
Diana Aparaschivei ◽  
Anamaria Todea ◽  
August E. Frissen ◽  
Valentin Badea ◽  
Gerlinde Rusu ◽  
...  
Keyword(s):  
Polymerization Reaction ◽  
Molar Ratio ◽  
Condensation Polymerization ◽  
Average Molecular Mass ◽  
New Class ◽  
Platform Chemicals ◽  
Starting Point ◽  
Reaction Cycles ◽  
Methylene Group

Abstract 2,5-Furandicarboxylic acid and itaconic acid are both important biobased platform chemicals and their terpolymer with 1,6-hexanediol (HDO) can be the starting point for a new class of reactive polyesters, with important applications. The green synthetic route developed in this study involves a biocatalytic condensation polymerization reaction of dimethyl furan-2,5-dicarboxylate (DMFDC) and dimethyl itaconate (DMI) with HDO in toluene at 80°C, using commercial immobilized lipases from Candida antarctica B. In the best conditions, the formed polymer product was isolated with more than 80% yield, containing about 85% terpolymer with average molecular mass of about 1200 (Mn, calculated from MALDI-TOF MS data) and 15% DMFDC_HDO copolymer. Considering the higher reactivity of DMFDC, the composition of the synthesized polymer can be directed by adjusting the molar ratio of DMFDC and DMI, as well as by extending the reaction time. Structural analysis by NMR demonstrated the regioselective preference for the carbonyl group from DMI adjacent to the methylene group. The biocatalyst was successfully reused in multiple reaction cycles.

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