Faculty Opinions recommendation of Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis.

2012 ◽  
Author(s):  
Kevin Moore
Keyword(s):  
Ursodeoxycholic Acid ◽  
Intrahepatic Cholestasis ◽  
Meta Analysis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis

2012 ◽  
Vol 143 (6) ◽  
pp. 1492-1501 ◽  
Author(s):  
Yannick Bacq ◽  
Loïc Sentilhes ◽  
Humberto B. Reyes ◽  
Anna Glantz ◽  
Jurate Kondrackiene ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Intrahepatic Cholestasis ◽  
Meta Analysis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

scholarly journals Emerging Medical Treatments of Intrahepatic Cholestasis of Pregnancy

2021 ◽  
pp. 243-248
Author(s):  
Sheema Sabahath ◽  
Fatmah AlDabbous ◽  
Mansour Mohammed ◽  
Ali Al Alhendi ◽  
Neda Al Yaqoot ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Intrahepatic Cholestasis ◽  
Meta Analysis ◽  
Fetal Distress ◽  
Treatment Modalities ◽  
Current Evidence ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Quality Of Reporting ◽  
Potential Efficacy ◽  
Cholestasis Of Pregnancy

Although intrahepatic cholestasis of pregnancy is not a serious one, it can be very distrustful to the affected women. It can also lead to significant complications and adverse events over the fetus as what has been previously reported that it is linked with stillbirth, fetal distress, and premature labor, especially in severely affected cases. Many treatment modalities have been proposed to relieve pruritis and enhance the levels of bile acids within the serum of the affected women. The administration of ursodeoxycholic acid has been studied by various studies in the literature, and evidence is conflicting about its potential efficacy and safety. However, recent evidence for a meta-analysis indicates that the modality can reduce pruritis. Nevertheless, the effect is minimal and not significant when compared to the placebo group. No significant differences were also noticed between the placebo and treatment groups. We also found that other treatment modalities than ursodeoxycholic acid can also be administered. Nonetheless, these were not adequately discussed in the literature, and therefore, should be cautiously administered within the clinical settings. Finally, further trials are needed to validate of the current evidence and enhance the quality of reporting and planning proper management guidelines.

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