Journal of Pharmaceutical Research International
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Published By Sciencedomain International

2456-9119
Updated Thursday, 28 October 2021

Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi ◽  
Bhuvnesh Kumar ◽  
...  

In material science, nanotechnology is considered as most common active area of research. Nanotechnology deals with the nanoparticles having a size range of 1-100nm used in medicinal chemistry, atomic physics. Nowadays, the use of metal nanoparticles in areas such molecular diagnostics and drug delivery, imaging, sensing has been of great scientific interest as a result of their peculiar optoelectronic and physicochemical properties. Thus synthesis of metal nanoparticles through effective, environmental friendly and cheaper approach is very important in nanotechnology research. In the current study Silver nanoparticles (AgNPs) were incorporated utilizing Azadiracta indica and Gardenia gummifera plant separate alongside their antimicrobial action. Silver had been a subject of interest from past a very long time because of its physical and chemical properties. Further depiction of mixed nanoparticles was finished by using Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM). The combined AgNPs were found with the size scope of 60-80nm. Antimicrobial movement of AgNPs was considered in contrast to S. aureus, E. coli and Pseudomonas aeruginosa. Thus the results indicate that the AgNPs may have an application in medical science.


Author(s):  
Sonal Dhobe ◽  
Seema Singh ◽  
Ranjana Sharma ◽  
Ruchira Ankar

Introduction: Complete Heart Block (CHB) occurs when the electrical signals can’t pass normally from the atria, the heart’s upper chambers, to the ventricles or lower chambers. This condition can develop because of congenital or secondary to cancers, myopathies or heart ischemia, infectious or endocrinological disorders and it needs comprehensive work-up to be excluded. Background: In the United States, the prevalence of third degree atrioventricular (AV) block that is  complete heart block is 0.02 percent.  The prevalence of third-degree AV blocks worldwide is 0.04 percent. With advancing age, the rate of AV conduction defects rises, resembling the age-related incidence of ischemic heart disease. Case Presentation: A case of 68 year old female admitted in cardiac ward on date 11 january 2021 with the chief complaint of breathlessness on exertion, restlessness, chest pain and loss of appetite since 2 month. The patient is a known case of hypertension since 5 year, Ischemic heart disease sine 1 year. after physical examination and other investigation like ECG, electrocardiogram the  she diagnosed as a complete heart block with third degree. Interventions: The patient was treated by placing permanent pacemaker on dated 18 january 2021. After that started the antibiotic like inj. targocid, inj. ceftriaxone, tab. linezolid, tab. orabest, tab. telmed H  and taking  also the anticoagulant therapy. She also under the care of cardiologists and monitor by hourly, also monitor the electric activity of pacemaker. Provide health education about healthy diet, life style modification, yoga and exercised, control over blood pressure and regular follow up. Conclusion: This study mainly focusing on the medical and placement of permanent pacemaker which help the heart to do their normal function and passing a normal electrical signals throught the heart rhythm. A good nursing care needed for the patient who have complete heart block and surgical implementation in permanent pacemaker  for continue monitored, no any complication can occur during or after pacemaker implantation. the patient response for the treatment was good and she recover rapidly.


Author(s):  
Kalyani Ambule ◽  
Manjusha Mahakarkar

Background: Pregnancy brings a slew of morphological and physiological changes to the body. The gravida must not only nourish the foetus, but also adjust to a new body habit and hormonal changes. These alterations, unsurprisingly, have an impact on the musculoskeletal system, which can lead to a number of issues, such as generalized arthralgias, back pain, separation of the pelvic bones, transient osteoporosis, and tendonitis. Objectives: 1. To assess the pretest and posttest musculoskeletal pain among postpartum women in experimental and control group. 2. To assess the effectiveness of postnatal exercises related to musculoskeletal pain among postpartum women in experimental group. 3. To find association between posttest musculoskeletal pain score among postpartum women with selected demographic variables in experimental and control group. Materials and Methods: Quasi-experimental pretest posttest design is used to assess the effectiveness of postnatal exercises, among postpartum women in selected hospitals of Wardha. 80 sample size taken who fulfils the inclusion criteria, 40 postpartum women for control and 40 for experimental group with non-probability convenience sampling. Expected Results: This study is planned to assess the effectiveness of postnatal exercises to the postpartum women experiencing musculoskeletal pain syndrome. Hence, it is expected to identify the level of pain and may reduce their level of pain. The conclusion will be drawn from the results and will be published in per review journal.


Author(s):  
Vu Thanh Binh ◽  
Dinh Tran Ngoc Huy ◽  
Pham Thi Bich Ngoc ◽  
Pham Thi Hong Nhung ◽  
Dinh Tran Ngoc Hien ◽  
...  

In the case of developing countries such as Vietnam, we will have a new approach of attacking corona virus and help patients at home with effective medicine treatment solutions as presented in this paper, it will help other nations as well and they can use it as reference. Authors will use qualitative analysis and experience and expertise from experts to explore this solution. Our study results show that there are several methods to treat corona patients at home effectively and that are tested in some countries including Vietnam. Currently Vietnam is testing Molnupiravir and other methods of treatment which will be presented, while WHO and Japan also have other approaches as presented in the study. Last but not least, authors suggest treatment of heart failures attached for patients and self-care knowledge for these patients.


Author(s):  
Pratibha Wankhede ◽  
Mayur Wanjari

Municipal solid waste (MSW) is hazardous to human health and the environment if not properly handled throughout all management processes, beginning with collection, separation, transfer, treatment, disposal, or recycling and reuse. The World Health Organization (WHO) has raised awareness of the dangers of improper solid waste disposal in terms of soil, water, and air pollution, as well as the health consequences for the people living in the surrounding areas. MSW production is predicted to reach 3.40 billion tonnes globally by 2050.  Inadequate waste management is one of the causes of the rise of infectious diseases. Most viruses, bacteria, and parasites that cause illness are found in blood, bodily fluids, and bodily secretions, which are components of bio-medical waste. This spreads through several human contacts, each of whom is a possible "receiver" of the illness. The Human Immunodeficiency Virus (HIV) and hepatitis viruses are at the forefront of a long list of illnesses and disorders that have been linked to biomedical waste. Other prevalent diseases spread owing to poor waste management include tuberculosis, pneumonia, diarrhea, tetanus, whooping cough, and others.


Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi

Aloe-Vera or Aloe barbadensis (botanical name) is a plant with many medicinal properties and have great importance in Ayurveda. Its leaves are succulent, erect, forming a thick rosette. The internal translucent pulp of Aloe-Vera is bound to a waxy crust or cuticle, and its vascular tissues transport minerals as well as water from the soil. Aloe Vera is being used as a major skin rejuvenating product, although it has varied medicinal properties also. In the present study, an attempt to make a method to create bi-layer tablets of Aloe-Vera, utilizing 3D printing techniques is presented. The method created doesnt affect the integral functional characteristics of the tablet. The method here contains creating an immediate release and sustained release tablet for making the Aloe-Vera to be used directly by the person for its numerous health effects. The tablet is designed so to be consumed by vegans as well since it is completely herbal.


Author(s):  
Pratiksha S. Thakare ◽  
Samruddhi Gujar ◽  
Shakib Sheikh ◽  
Vrushali Dighikar

The causative factors of Coronavirus disease mainly the viruses. Through news we aware that pneumonia cases seen recently in Wuhan city, China. Due to unknown causes. Coronaviruses that cause illness such as a common cold. The Coronavirus infection identified with respiratory symptoms and pneumonia, the severe form of coronavirus infection mainly associated with death and low immune system patients. It is very important for us to more focus on geriatric people because in our countries, geriatric group people facing health problems at this present situation. According to articles Clinical Pathology, Pathogenesis, Immunopathology, and Mitigation Strategies, in that said geriatric people and low immune system patient with symptoms related history are more prone to COVID infection. But according to recent information by WHO all people are at risk of coronavirus but mostly geriatric people facing more risk of developing a severe respiratory infection. Geriatric people easily get coronavirus syndrome due to physical changes that occur as increasing age. There were 95% of these deaths seen in geriatric people above 60 years older. Above 50% of all fatal conditions occurred in geriatric people between 60- 80 years ago. There having disease control and prevention center, which indicate that rates of hospitalizations, intensive care unit admissions and mortality reported among COVID-19 cases in the United States are substantially higher among patients older than 45 years compared with younger patients, with case-fatality rates exceeding 1.4% among patients aged 55 to 64 years and exceeding 2.7% among those aged 65 to 74 years.


Author(s):  
Sonal Dhobe ◽  
Seema Singh

Background: Nutritional anemia is a disorder that cause due to a lack of one or more vital nutrients, such as iron, protein, vitamin B12, and other vitamins and minerals. In this condition hemoglobin content in the blood is lower than usual. Nutritional anemia has been described as correlated with reduced childhood emotional, physical, and cognitive function and is a major risk factor for maternal mortality. Objective: 1. To assess the prevalence of nutritional anemia among adolescent girls. 2. To assess the causes of nutritional anemia among adolescent girls. 3. To associate the demographic variable with prevalence and causes of nutritional anemia among adolescent girls. Methodology: This is a cross sectional observational study will be conducted among the adolescent girls where age is between 10-14 years, the sample size can be calculated statistically by using the prevalence of previous studies which done in India and the sample size is 220 adolescent girls selected in a particular rural community area of Wardha district. Non-probability convenience sampling will be using for sample collection. The standard haemoglobinometer (Accusure HB meter) for analyzing the haemoglobin according to WHO criteria and structure questionnaire scale is made upon the causes behind the nutritional anemia. According to some previous studies, the prevalence rate has been shown high in the adolescent age group so this study help to find the prevalence rate in a particular community and the causes of nutritional anemia among adolescent girls. Expected Results: In this study the researcher evaluate the prevalence and its causes of nutritional anemia among adolescent girls, this study will show the rate of prevalence in the particular community area and also the causes of nutritional anemia among adolescent girls. Conclusion: The conclusion will be drawn from the results.


Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi

Nipah Virus is a zoo tonic virus and has re-emerged again with more deadliness. NiV has infected many animals and humans worldwide and a huge loss to life has been faced. NiV contains a Fusion protein on its outer membrane which helps in the virus entry into the host cell. This fusion protein is a virulent factor and is a major anti-viral target. Many medicinal plants have been used against viral diseases, current research aims towards the potential of three daily dietary food elements that can be used as an anti-viral agent. In-silico studies are performed with 4-hyroxypanduratin A, 6-gingerol and Luteolin against the NiV-F and binding energies were calculated. It was reported that these phyto-compounds have good negative binding energies and they have the promising potential against Nipah Virus. Further in-vitro research can be performed with these phyto-compounds to design a specific drug against Nipah Virus.


Author(s):  
Milind S. Pande ◽  
Neelanchal Trivedi ◽  
Bhuvnesh Kumar

Jatropha gossypiifolia L. broadly addressed as bellyache bush, refers to therapeutic plant utilized all through Asian countries. A few human and veterinary utilizations in conventional medication are portrayed for various specifics and arrangements dependent on aforementioned plant. This paper give a cutting-edge review of conventional uses, pharmacology, and toxicology of J. gossypiifolia species, taking into account examination of its therapeutic worth and potential application in integral and elective medication. Pharmacological examinations have exhibited noteworthy activity of various concentrates elements as anti-microbial, mitigating, anti-diarrheal, anti-hypertensive, and anti-cancerous specialists, among different, supporting a portion of famous employments. No clinical preliminary was distinguished to date. Moreover investigations are important to test significant society utilizations, just as to discover naive bioactive atoms with pharmacological pertinence dependent on the well-known cases. Toxicological investigations related with phytochemical examination are critical to comprehend the possible lethal impacts that could lessen its restorative worth. The current review gives bits of knowledge to future research focusing on both ethnopharmacological approval of its famous use and its investigation as another wellspring of home grown medications and additionally bioactive characteristic items.


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