Faculty Opinions recommendation of Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.

2015 ◽  
Author(s):  
Ramsay Fuleihan ◽  
Whitney Stevens
Keyword(s):  
Inflammatory Bowel Disease ◽  
Common Variable Immunodeficiency ◽  
Bowel Disease ◽  
Early Onset ◽  
Inflammatory Bowel ◽  
Common Variable

Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency

2014 ◽  
Vol 133 (6) ◽  
pp. 1651-1659.e12 ◽  
Author(s):  
Elisabeth Salzer ◽  
Aydan Kansu ◽  
Heiko Sic ◽  
Peter Májek ◽  
Aydan Ikincioğullari ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Common Variable Immunodeficiency ◽  
Bowel Disease ◽  
Early Onset ◽  
Inflammatory Bowel ◽  
Common Variable

Excess IL-12 but not IL-23 Accompanies the Inflammatory Bowel Disease Associated With Common Variable Immunodeficiency

2006 ◽  
Vol 131 (3) ◽  
pp. 748-756 ◽  
Author(s):  
Peter J. Mannon ◽  
Ivan J. Fuss ◽  
Susie Dill ◽  
Julia Friend ◽  
Catherine Groden ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Common Variable Immunodeficiency ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Common Variable

scholarly journals Different renal manifestations associated with very early onset pediatric inflammatory bowel disease: case report and review of literature

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
A. Angeletti ◽  
S. Arrigo ◽  
A. Madeo ◽  
M. Molteni ◽  
E. Vietti ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Interstitial Nephritis ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Early Onset ◽  
Renal Involvement ◽  
Granulomatous Interstitial Nephritis ◽  
Disease Case ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Abstract Background Inflammatory bowel diseases are characterized by chronic inflammation of the gastrointestinal tract. In particular, Crohn disease and ulcerative colitis represent the two most common types of clinical manifestations. Extraintestinal manifestations of inflammatory bowel diseases represent a common complications, probably reflecting the systemic inflammation. Renal involvement is reported in 4–23% of cases. However, available data are limited to few case series and retrospective analysis, therefore the real impact of renal involvement is not well defined. Case presentation We report the case of a 10-years old male affected by very early onset unclassified-Inflammatory bowel diseases since he was 1-year old, presenting with a flare of inflammatory bowel diseases associated with acute kidney injury due to granulomatous interstitial nephritis. Of interest, at 7-year-old, he was treated for IgA nephropathy. To our knowledge, no previous reports have described a relapse of renal manifestation in inflammatory bowel diseases, characterized by two different clinical and histological phenotypes. Conclusions The link between the onset of kidney injuries with flares of intestinal inflammation suggest that nephritis maybe considered an extra-intestinal manifestation correlated with active inflammatory bowel disease. However, if granulomatous interstitial nephritis represents a cell-mediated hypersensitivity reaction than a true extraintestinal manifestation of inflammatory bowel diseases is still not clarified. We suggest as these renal manifestations here described may be interpreted as extraintestinal disorder and also considered as systemic signal of under treatment of the intestinal disease.

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