Faculty Opinions recommendation of A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models.

2017 ◽  
Author(s):  
Charles M Rice ◽  
Mohsan Saeed
Keyword(s):  
Mouse Models ◽  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Sterilizing Immunity

scholarly journals A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

2017 ◽  
Vol 23 (6) ◽  
pp. 763-767 ◽  
Author(s):  
Chao Shan ◽  
Antonio E Muruato ◽  
Bruno T D Nunes ◽  
Huanle Luo ◽  
Xuping Xie ◽  
...  
Keyword(s):  
Mouse Models ◽  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Sterilizing Immunity

Dengue and Zika Virus Infections Are Enhanced by Live Attenuated Dengue Vaccine but Not by Recombinant DSV4 Vaccine Candidate in Mouse Models

2020 ◽  
Author(s):  
Rahul Shukla ◽  
Julia A. Brown ◽  
Hemalatha Beesetti ◽  
Richa Ahuja ◽  
Viswanathan Ramasamy ◽  
...  
Keyword(s):  
Mouse Models ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Virus Infections ◽  
Dengue Vaccine

scholarly journals Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models

EBioMedicine ◽  
2020 ◽  
Vol 60 ◽  
pp. 102991 ◽  
Author(s):  
Rahul Shukla ◽  
Hemalatha Beesetti ◽  
Julia A. Brown ◽  
Richa Ahuja ◽  
Viswanathan Ramasamy ◽  
...  
Keyword(s):  
Mouse Models ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Virus Infections ◽  
Dengue Vaccine

scholarly journals A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

2020 ◽  
Vol 9 (1) ◽  
pp. 520-533 ◽  
Author(s):  
Dieudonné Buh Kum ◽  
Robbert Boudewijns ◽  
Ji Ma ◽  
Niraj Mishra ◽  
Dominique Schols ◽  
...  
Keyword(s):  
Virus Infection ◽  
Yellow Fever ◽  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Yellow Fever Virus ◽  
Fever Virus

scholarly journals Erratum for Chen et al., “Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate”

mBio ◽  
2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Qi Chen ◽  
Jin Wu ◽  
Qing Ye ◽  
Feng Ma ◽  
Qian Zhu ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Human Glioblastoma ◽  
Al Treatment

scholarly journals A single-dose live attenuated chimeric vaccine candidate against Zika virus

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Wei-Xin Chin ◽  
Regina Ching Hua Lee ◽  
Parveen Kaur ◽  
Tian Sheng Lew ◽  
Thinesshwary Yogarajah ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Candidate ◽  
Effective Vaccine ◽  
Neutralising Antibodies ◽  
Live Attenuated Vaccine ◽  
Live Virus ◽  
Plaque Phenotype ◽  
Chimeric Vaccine

AbstractThe mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature sensitivity, attenuation of neurovirulence in suckling mice, and attenuation of pathogenicity in interferon deficient adult AG129 mice. VacDZ may be administered as a traditional live virus vaccine, or as a DNA-launched vaccine that produces live VacDZ in vivo after delivery. Both vaccine formulations induce a protective immune response against Zika virus in AG129 mice, which includes neutralising antibodies and a strong Th1 response. This study demonstrates that VacDZ is a safe and effective vaccine candidate against Zika virus.

Sign in / Sign up

Export Citation Format

Share Document