Faculty Opinions recommendation of Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.

2020 ◽  
Author(s):  
Ed Manser
Keyword(s):  
Interaction Network ◽  
Regulatory Mechanisms ◽  
Signalling Pathways ◽  
Rho Family Gtpases ◽  
Rho Family

Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

2019 ◽  
Vol 22 (1) ◽  
pp. 120-134 ◽  
Author(s):  
Halil Bagci ◽  
Neera Sriskandarajah ◽  
Amélie Robert ◽  
Jonathan Boulais ◽  
Islam E. Elkholi ◽  
...  
Keyword(s):  
Interaction Network ◽  
Regulatory Mechanisms ◽  
Signalling Pathways ◽  
Rho Family Gtpases ◽  
Rho Family

scholarly journals Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

2020 ◽  
Vol 22 (3) ◽  
pp. 353-353
Author(s):  
Halil Bagci ◽  
Neera Sriskandarajah ◽  
Amélie Robert ◽  
Jonathan Boulais ◽  
Islam E. Elkholi ◽  
...  
Keyword(s):  
Interaction Network ◽  
Regulatory Mechanisms ◽  
Signalling Pathways ◽  
Rho Family Gtpases ◽  
Rho Family

scholarly journals How cells determine the number of polarity sites

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Jian-geng Chiou ◽  
Kyle D Moran ◽  
Daniel J Lew
Keyword(s):  
Design Principle ◽  
Fundamental Question ◽  
Yeast Cells ◽  
Regulatory Mechanisms ◽  
Saturation Point ◽  
Rho Family Gtpases ◽  
Rho Family ◽  
Theoretical Analyses ◽  
Novel Design ◽  
Insight Into

The diversity of cell morphologies arises, in part, through regulation of cell polarity by Rho-family GTPases. A poorly understood but fundamental question concerns the regulatory mechanisms by which different cells generate different numbers of polarity sites. Mass-conserved activator-substrate (MCAS) models that describe polarity circuits develop multiple initial polarity sites, but then those sites engage in competition, leaving a single winner. Theoretical analyses predicted that competition would slow dramatically as GTPase concentrations at different polarity sites increase towards a 'saturation point', allowing polarity sites to coexist. Here, we test this prediction using budding yeast cells, and confirm that increasing the amount of key polarity proteins results in multiple polarity sites and simultaneous budding. Further, we elucidate a novel design principle whereby cells can switch from competition to equalization among polarity sites. These findings provide insight into how cells with diverse morphologies may determine the number of polarity sites.

Rho family GTPases Integrate Angiogenic Signalling Pathways

2002 ◽  
Vol 103 (s47) ◽  
pp. 26P-27P
Author(s):  
John O Connolly ◽  
Alan Hall
Keyword(s):  
Signalling Pathways ◽  
Rho Family Gtpases ◽  
Rho Family

The role of Rho-family GTPases in human glioblastomas

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
S Seta ◽  
M Herr ◽  
S Horn ◽  
D Koch ◽  
T Vogt ◽  
...  
Keyword(s):  
Rho Family Gtpases ◽  
Rho Family

scholarly journals R-cadherin influences cell motility via Rho family GTPases. Vol. 279 (2004) 31041-31049

2004 ◽  
Vol 279 (42) ◽  
pp. 44229-44230
Author(s):  
Emhonta Johnson ◽  
Christopher S. Theisen ◽  
Keith R. Johnson ◽  
Margaret J. Wheelock
Keyword(s):  
Cell Motility ◽  
Rho Family Gtpases ◽  
Rho Family

scholarly journals Structure Based Drug Design in Novel Druggable Pockets on Rho Family GTPases

2012 ◽  
Vol 102 (3) ◽  
pp. 620a
Author(s):  
Juan Manuel Ortiz-Sanchez ◽  
Barry J. Grant ◽  
J. Andrew McCammon
Keyword(s):  
Drug Design ◽  
Structure Based Drug Design ◽  
Rho Family Gtpases ◽  
Rho Family

scholarly journals Apolar and polar transitions drive the conversion between amoeboid and mesenchymal shapes in melanoma cells

2015 ◽  
Vol 26 (22) ◽  
pp. 4163-4170 ◽  
Author(s):  
Sam Cooper ◽  
Amine Sadok ◽  
Vicky Bousgouni ◽  
Chris Bakal
Keyword(s):  
Quantitative Imaging ◽  
Three Dimensional ◽  
Shape Space ◽  
Melanoma Cells ◽  
Collagen Matrices ◽  
Morphological Heterogeneity ◽  
Rho Family Gtpases ◽  
Metastatic Process ◽  
Rho Family ◽  
Single Living

Melanoma cells can adopt two functionally distinct forms, amoeboid and mesenchymal, which facilitates their ability to invade and colonize diverse environments during the metastatic process. Using quantitative imaging of single living tumor cells invading three-dimensional collagen matrices, in tandem with unsupervised computational analysis, we found that melanoma cells can switch between amoeboid and mesenchymal forms via two different routes in shape space—an apolar and polar route. We show that whereas particular Rho-family GTPases are required for the morphogenesis of amoeboid and mesenchymal forms, others are required for transitions via the apolar or polar route and not amoeboid or mesenchymal morphogenesis per se. Altering the transition rates between particular routes by depleting Rho-family GTPases can change the morphological heterogeneity of cell populations. The apolar and polar routes may have evolved in order to facilitate conversion between amoeboid and mesenchymal forms, as cells are either searching for, or attracted to, particular migratory cues, respectively.

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