Effects of intra-articular botulinum toxin type A (Botox®) in dogs with chronic osteoarthritis

2010 ◽  
Vol 23 (04) ◽  
pp. 254-258 ◽  
Author(s):  
J. L. Wheeler ◽  
S. W. Petersen ◽  
H. S. Hadley

Summary Objectives: To evaluate the effects of intra-articular botulinum neurotoxin type A (BoNT/A) in dogs with chronic osteo-arthritis. Methods: Client-owned dogs with lameness and discomfort attributed to unilateral elbow or hip osteoarthritis were eligible for inclusion (n = 5). All dogs had BoNT/A (25 units) administered to the affected joint (2 elbows, 3 hips). Dogs were evaluated by pressure platform gait analysis before and at two, four, eight, and 12 weeks post-injection, and by client perception of outcome. Results: In experimental limbs, ground reaction forces (peak vertical force and vertical impulse) consistently improved for a variable period of time following intra-articular BoNT/A therapy. These changes were not, however, observed in the contralateral limbs, in which values remained relatively unchanged or decreased. Four out of five owners reported at least some improvement in their dog’s condition following treatment. Clinical significance: A multimodal approach with the intra-articular administration of BoNT/A may be an option for osteoarthritis patients that are unresponsive to medical management and unable to undergo surgery. However, the findings of this study are preliminary and must be verified by further investigation.

2020 ◽  
Vol 11 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Marie-Michèle Briand ◽  
Mathieu Boudier-Réveret ◽  
Xavier Rodrigue ◽  
Geneviève Sirois ◽  
Min Cheol Chang

AbstractMovement disorders post-amputation are a rare complication and can manifest as the jumping stump phenomenon, a form of peripheral myoclonus. The pathophysiology remains unknown and there is currently no standardized treatment. We describe the case of a 57-year-old male with unremitting stump myoclonus, starting one month after transtibial amputation, in his residual limb without associated phantom or neurological pain. The consequence of the myoclonus was a reduction in prosthetic wearing time. Failure to respond to oral medication led us to attempt the use of botulinum neurotoxin Type A injections in the involved muscles of the residual limb. Injection trials, over a two-year period, resulted in an improvement of movement disorder, an increased prosthetic wearing time and a higher satisfaction level of the patient. Injection of botulinum toxin type A should be considered as an alternative treatment for stump myoclonus to improve prosthetic wearing time and comfort.


2005 ◽  
Vol 18 (1) ◽  
pp. 29
Author(s):  
Dong Eon Moon ◽  
Young Eun Moon ◽  
Shi Hyeon Kim ◽  
Eun Sung Kim

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