scholarly journals Retinopatía de la prematuridad y su evolución en niños sobrevivientes de bajo peso al nacer egresados del Servicio de Neonatología del Hospital Regional Docente de las Mercedes de Chiclayo durante 2012-2013

2018 ◽  
Vol 10 (2) ◽  
pp. 85-89
Author(s):  
Vanessa Fustamante-Sánchez ◽  
Carlos Santamaría-Santamaría ◽  
Ricardo Peña-Sánchez
Keyword(s):  
Normal Retina

Objetivo: Describir la evolución de retinopatía de la prematuridad (ROP) en recién nacidos con bajo peso al nacer egresados del Servicio de Neonatología del Hospital Regional Docente de las Mercedes durante los años 2012-2013. Materiales y Métodos: Estudio descriptivo, transversal y retrospectivo que se incluyeron 118 recién nacidos pretérmino (RNPT) e excluyó a 25 sobrevivientes por ser referidos a otras instituciones, padecer de malformaciones congénitas o tener su ficha clínica incompleta. Se registró su evolución con respecto de la ocurrencia de ROP en los siguientes seis controles posterior a su nacimiento. Resultados: De los 118 RN con bajo peso al nacer, al final del período de estudio el 50.8% (60) evolucionaron en hacia la regresión espontánea con diagnóstico previo de ROP y en 16,9% (20) a estadios que necesitaron tratamiento con laserterapia, el restante 32,2% (38) tuvo buenos resultados con fondo de ojo normal (retina madura) previo a un diagnóstico de retina inmadura. Se encontró diferencia significativa en el promedio del peso al nacer (p˂0,001, análisis de varianza) en los tres grupos estudiados. No se evidenció diferencias significativas entre la evolución de los RN por sexo. Conclusiones: Se encontró una frecuencia de 42% de ROP en los RNPT evaluados. Una asociación entre peso del RN y la necesidad de requerir laserterapia. En los RN de sexo masculino aprox. el 55% se ven curados durante el tercer control mientras que el sexo femenino lo hicieron en un 45 %.

A cancer-associated lactate dehydrogenase is expressed in normal retina

Science ◽  
1983 ◽  
Vol 221 (4607) ◽  
pp. 291-292 ◽  
Author(s):  
R. Saavedra ◽  
G. Anderson
Keyword(s):  
Lactate Dehydrogenase ◽  
Normal Retina

scholarly journals Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina: Evidence for Involvement in Diabetic Retinopathy

Diabetes ◽  
2004 ◽  
Vol 53 (4) ◽  
pp. 1104-1110 ◽  
Author(s):  
H.-P. Hammes ◽  
J. Lin ◽  
P. Wagner ◽  
Y. Feng ◽  
F. vom Hagen ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Normal Retina ◽  
Angiopoietin 2

scholarly journals CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE

1973 ◽  
Vol 57 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Susan Y. Schmidt ◽  
Richard N. Lolley
Keyword(s):  
Cyclic Amp ◽  
Cyclic Nucleotide ◽  
Photoreceptor Cell ◽  
Specific Activity ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Normal Strain ◽  
Cell Degeneration ◽  
Newborn Mice ◽  
Normal Retina ◽  
C3h Mice

Cyclic nucleotides have been implicated in the differentiation and function of the vertebrate retina. In the normal retina of DBA mice, the specific activity of cyclic-nucleotide phosphodiesterase (PDE), with cyclic-AMP as the substrate (cAMP-PDE), increases eightfold between the 6th and 20th postnatal day. Kinetic analysis of retinae from newborn mice reveals a PDE with a single Michaelis constant (Km) value for cyclic-AMP (low Km-PDE). After the 6th postnatal day, a second PDE with a high Km for cyclic-AMP (high Km-PDE) can be demonstrated. The appearance and increasing activity of the high Km-PDE coincides with the differentiation and growth of photoreceptor outer segments. Additionally, the high Km-PDE is shown by microchemical techniques to be concentrated in the photoreceptor cell layer and the low Km-PDE within the inner layers of the normal retina. In C3H mice afflicted with an inherited degeneration of the photoreceptor layer, the postnatal increase in the specific activity of cAMP-PDE is substantially lower than in the normal retina. The postnatal increase in the specific activity of cAMP-PDE in two regions of the brain of C3H mice is the same as in the normal strain. A deficiency in high Km-PDE activity in the C3H retina is evident on the 7th postnatal day, when the activity of low Km-PDE, photoreceptor morphology, and rhodopsin content of these retina are essentially normal. In the adult C3H retina, the PDE activity with cyclic-GMP and cyclic-UMP as substrates is significantly below that of the normal retina. These data indicate that an alteration in cyclic-AMP metabolism occurs before photoreceptor cell degeneration in the retinae of C3H mice.

scholarly journals Color-Vision Mechanisms in the Peripheral Retinas of Normal and Dichromatic Observers

1973 ◽  
Vol 61 (2) ◽  
pp. 125-145 ◽  
Author(s):  
B. R. Wooten ◽  
George Wald
Keyword(s):  
Color Vision ◽  
Color Blindness ◽  
Neural Pathways ◽  
Color Adaptation ◽  
Normal Retina ◽  
Fixation Area

It is possible that so-called normal trichromatic vision occurs only between the central blue-blind fixation area and about 30° peripherally. Beyond about 30° vision has been alleged to become dichromatic (red-green blind), and beyond about 60°, monochromatic. Hence every form of color blindness may characterize various zones of the normal retina. We have studied mechanisms of peripheral color vision, mainly by measuring the spectral sensitivities of the blue-, green-, and red-sensitive systems, isolated by differential color adaptation. In normal observers the sensitivity of the blue-mechanism falls off about 2 log units by 80° out. The green- and red-sensitive systems decline only about 0.7 log unit over the same range. Protanopes, deuteranopes, and tritanopes exhibit comparable changes. We have not found any color mechanism present centrally to be wholly lost peripherally. Nor, for dichromats, have we found any mechanism missing centrally to be present peripherally. Whatever evidences of peripheral color blindness have been observed appear to involve other mechanisms than failure of receptors, probably including some fusion of neural pathways from receptors to centers.

scholarly journals OCT Angiography and En Face OCT Reflectance Aid in Monitoring Subclinical Inflammation in Serpiginous Choroidopathy

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Carl S. Wilkins ◽  
Jorge S. Andrade Romo ◽  
Toco Y. P. Chui ◽  
Richard B. Rosen ◽  
Stephanie Llop
Keyword(s):  
Disease Progression ◽  
Transition Zone ◽  
Multimodal Imaging ◽  
Primary Site ◽  
Subclinical Inflammation ◽  
Case Presentation ◽  
Normal Retina ◽  
Subclinical Disease ◽  
En Face Oct ◽  
En Face

Introduction. We present a case of serpiginous choroidopathy (SC) with novel OCTA and en face OCT reflectance findings which help identify subclinical disease progression. Case Presentation. En face OCT reflectance images demonstrated outer retinal tubules (ORT) at the serpiginous lesion margins of affected and unaffected retina on multimodal imaging. OCTA findings demonstrate variable dropout of choriocapillaris in “normal” retina beyond lesion borders which was not visible on standard imaging and which demonstrated a clear transition zone beyond the ORT. Discussion. This is the first report of choriocapillaris atrophy identified on OCTA not identified on traditional multimodal imaging in serpiginous choroidopathy. Damage to vasculature only visible with OCTA may help characterize the distribution of inflammation, aiding in monitoring of suppression not illustrated by traditional imaging and which may threaten the central macula. ORT in SC suggest death and reorganization of outer segments from dysfunction of the choriocapillaris and RPE, as well as serve to demarcate the area of chronic or old inflammation, supporting the hypothesis that the choriocapillaris is the primary site of inflammation in SC. Based on these findings, we recommend OCTA on all patients with serpiginous choroidopathy to monitor underlying state of inflammation and help determine immunosuppressive threshold.

scholarly journals Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies

2007 ◽  
Vol 12 (4) ◽  
pp. 041207 ◽  
Author(s):  
Maciej Szkulmowski ◽  
Maciej Wojtkowski ◽  
Bartosz Sikorski ◽  
Tomasz Bajraszewski ◽  
Vivek J. Srinivasan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Normal Retina ◽  
Retinal Layers ◽  
Spectral Optical Coherence Tomography ◽  
Retinal Pathologies
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