scholarly journals EFFICACY OF CORNEAL COLLAGEN CROSSLINKING WITH RIBOFLAVIN AND ULTRAVIOLET-A IN PROGRESSIVE KERATOCONUS.

2020 ◽  
pp. 1-3
Author(s):  
Priyanka Raut ◽  
Nikhilesh * Wairagade ◽  
Praneeta Sakarkar
Keyword(s):  
P Value ◽  
Spherical Equivalent ◽  
Ultraviolet A ◽  
Collagen Crosslinking ◽  
Institutional Ethics ◽  
Uncorrected Visual Acuity ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
A Prospective Study ◽  
Corneal Collagen

PURPOSE-To evaluate outcomes of collagen crosslinking in patients having progressive keratoconus. METHODS- A prospective study was done in eyes that underwent corneal collagen crosslinking for treatment of progressive keratoconus. This study was performed after approval from Institutional Ethics Committee and informed consent was obtained from all the patients. Data was analysed with the help of JASP0.8.3.1 and MS-Excel 2013. RESULT-The mean age was 20.94 ± 2.04 years. 21 (63.63%) were males, 12 (36.36 %) were females. The mean uncorrected visual acuity (UCVA) pre-operative and post-operative at 6 months were 0.64 ± 0.37 and 0.53 ± 0.31 (logMAR) respectively (p value 0.03). Mean spherical equivalent pre-operatively and post-operatively at 6 months were -2.85 ± 2.14 and -2.38 ± 1.70 respectively (p < 0.001). Mean keratometry (Mean K) preoperative and post-operative were 49.85 ± 4.10 Dioptres (D) and 49.22 ± 4.09 D respectively (p = 0.0007). CONCLUSION- Corneal collagen crosslinking with UV-A and riboavin is a safe and effective method for halting the deterioration of progressive keratoconus.

scholarly journals Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Deepa Viswanathan ◽  
Nikhil L. Kumar ◽  
John J. Males
Keyword(s):  
Young Patients ◽  
Ultraviolet A ◽  
Effective Treatment Option ◽  
Collagen Crosslinking ◽  
Paediatric Patients ◽  
Corneal Grafting ◽  
Minimum Angle ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51).Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.

Influence of Corneal Collagen Crosslinking with Riboflavin and Ultraviolet-A Irradiation on Excimer Laser Surgery

2010 ◽  
Vol 51 (8) ◽  
pp. 3929 ◽  
Author(s):  
Daniel Kampik ◽  
Bernhard Ralla ◽  
Sabine Keller ◽  
Markus Hirschberg ◽  
Peter Friedl ◽  
...  
Keyword(s):  
Excimer Laser ◽  
Laser Surgery ◽  
Ultraviolet A ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus

2010 ◽  
Vol 36 (10) ◽  
pp. 1724-1727 ◽  
Author(s):  
George D. Kymionis ◽  
Michael A. Grentzelos ◽  
George A. Kounis ◽  
Dimitra M. Portaliou ◽  
Efstathios T. Detorakis ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Pressure Measurements ◽  
Ultraviolet A ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

Successful Regression in Patients with Progressive Keratoconus by Corneal Crosslinking

2021 ◽  
Author(s):  
Tobias Röck ◽  
Eva-Maria Konrad ◽  
Daniel Röck ◽  
Matthias Bramkamp ◽  
Gunnar Blumenstock ◽  
...  
Keyword(s):  
Statutory Health Insurance ◽  
Observation Time ◽  
Collagen Crosslinking ◽  
Corrected Visual Acuity ◽  
Before And After ◽  
Study Population ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
The University ◽  
Corneal Collagen

Abstract Background Since 2019, corneal collagen crosslinking (CXL) is included in the catalog of procedures covered by statutory health insurance in Germany. CXL is an established ophthalmological procedure for the last 20 years. The aim of this investigation was the measurement of progression before and after CXL. Material und Methods 65 consecutive eyes with progressive keratoconus from 53 patients were included in the retrospective study, which were observed at the University Eye Hospital Tübingen at least two years before and at least two years after CXL. The time of observation took place from October 2009 until March 2018. Parameters of interest had been the best corrected visual acuity (BCVA) and the keratometric values from the elevation maps measured by a Scheimpflug camera. Results 65 eyes of 53 patients had been documented. The study population included 46 (86.8%) male and 7 (13.2%) female subjects. The mean age was 24 ± 8 years. The averaged observation time between the primary consultation and CXL showed 25 ± 15 months. Preoperatively the mean BCVA pointed out in a significant increase (0.13 ± 0.17 [first visit] vs. 0.23 ± 0.22 [preOP], p < 0.0001) while the mean Kmax resulted in a statistically significant increase (46.34 ± 3.33 dpt [first visit] vs. 48.78 ± 4.17 dpt [preOP], p < 0.0001). The mean thinnest point of the cornea showed a significant decrease (490.48 ± 34.23 µm [first visit] vs. 468.62 ± 29.84 µm [preop], p < 0.0001). Postoperatively the mean BCVA resulted in a significant improvement at the 12th postoperative month in comparison to the preoperative measurement (0.23 ± 0.22 [preOP] vs. 0.16 ± 0.14 [12 months], p = 0.04 respectively 0.17 ± 0.17 [24 months], p = 0.0006). The mean Kmax demonstrated in the 12th postoperative month a significant reduction (48.78 ± 4.17 dpt [preOP] vs. 47.91 ± 3.41 dpt [12 months], p = 0.0009 respectively 48 ± 4.56 dpt [24 months], p = 0.0051). The mean thinnest point of the cornea indicated a decrease at the 12th postoperative month (468.62 ± 29.84 µm [preOP] vs. 459.82 ± 35.88 µm [12 months], p = 0.0078 respectively 453.47 ± 43.39 µm [24 months], p = 0.0227). Conclusion CXL is a successful procedure for the therapy of progressive keratoconus.

scholarly journals Extensive Corneal Neovascularisation Treatment by Ultraviolet Corneal Collagen Crosslinking

2017 ◽  
Vol 11 (01) ◽  
pp. 62
Author(s):  
Mohammad M Shehadeh ◽  
Mohammad T Akkawi ◽  
Vasilios F Diakonis ◽  
Ammar A Aghbar ◽  
Abdelraheem Abu Shanab ◽  
...  
Keyword(s):  
Case Report ◽  
Dramatic Improvement ◽  
Ultraviolet A ◽  
Collagen Crosslinking ◽  
Topical Antibiotics ◽  
Full Resolution ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

The purpose of this article is to report a case of extensive corneal neovascularisation that was treated by ultraviolet corneal collagen crosslinking (CXL). The case report is about a 24-year-old man who was referred to the cornea clinic with a case of keratitis. He was treated with topical antibiotics. After full resolution of keratitis, his condition was complicated by extensive corneal neovascularisation. A trial of photochemical corneal collagen CXL with riboflavin/ultraviolet A resulted in a dramatic improvement and resolution of the corneal neovascularisation. Thus, we can conclude that corneal collagen CXL could be a promising procedure to treat certain cases of extensive corneal neovascularisation.

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