scholarly journals SYNTHESIS OF MONO [6A-O- (4-TOLYLSULPHONYL)] -β-CYCLODEXTRIN

2020 ◽  
Vol 2018 (1) ◽  
pp. 31-33
Author(s):  
Thi Thyui Nguen ◽  
Nina Shaglaeva ◽  
Vladimir Novokshonov
Keyword(s):  
Alkaline Medium ◽  
Preparation Procedure ◽  
Target Product ◽  
Aqueous Alkaline Medium ◽  
Tosyl Chloride

As a result of improvement of the preparation procedure of tosyl-β-cyclodextrin in aqueous alkaline medium by the interaction of β-cyclodextrin with tosyl chloride (TosCl) at low temperatures, the yield of the target product was increased from 38% to 58%.

scholarly journals Interaction of β-cyclodextrin with tosyl chloride in an aqueous alkaline medium

2019 ◽  
Vol 3 (9) ◽  
pp. 366-375
Author(s):  
Vladimir V. Novokshonov ◽  
◽  
Nguyen Thi Thu Xuan ◽  
Nina S. Shaglaeva ◽  
Tatiana A. Podgorbunskaya ◽  
...  
Keyword(s):  
Alkaline Medium ◽  
Aqueous Alkaline Medium ◽  
Tosyl Chloride

Linear Synthesis of {4-[(2-Alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones as Possible Therapeutic Agents

2019 ◽  
Vol 41 (4) ◽  
pp. 685-685
Author(s):  
Muhammad Athar Abbasi Muhammad Athar Abbasi ◽  
Wajiha Khan Wajiha Khan ◽  
Aziz ur Rehman Aziz ur Rehman ◽  
Sabahat Zahra Siddiqui Sabahat Zahra Siddiqui ◽  
Ghulam Hussain Ghulam Hussain ◽  
...  
Keyword(s):  
Alkaline Medium ◽  
Inhibitory Activity ◽  
Substitution Reaction ◽  
Parent Compound ◽  
Ph Control ◽  
Therapeutic Agents ◽  
Lithium Hydride ◽  
Aqueous Alkaline Medium

In the present work, a series of {4-[(2-alkyloxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones was synthesized through a linear bi-step approach. The synthesis was initiated by the coupling of 2-furyl(1-piperazinyl)methanone (1) with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) under dynamic pH control in aqueous alkaline medium to form parent compound, {4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanone (3). Then, the O-substitution reaction on nucleophile 3 was carried out by treating it with different alkyl/aralkyl halides (4a-l) in the presence of lithium hydride (LiH) and N,N-dimethylformamide (DMF) to obtained the designed {4-[(2-alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones (5a-l). These synthesized compounds were screened against α-glucosidase enzyme and some of them exhibited considerable inhibitory activity. Additionally, compounds were also evaluated for hemolytic and cytotoxic profile.

Studies on the ketone-catalyzed decomposition of caroate in aqueous alkaline medium

2005 ◽  
Vol 37 (8) ◽  
pp. 483-488 ◽  
Author(s):  
S. Selvararani ◽  
B. Medona ◽  
M. S. Ramachandran
Keyword(s):  
Alkaline Medium ◽  
Aqueous Alkaline Medium
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