The large airspace varying trajectory is modified to large airspace spiral maneuver trajectory, in order to improve the penetration effect of a supersonic anti-warship missile against enemy long-distance ship-to-air missile (LDSAM). In the descent phase the missile may suffer the interception of LDSAM, so the descent phase is modified to spiral maneuver descent trajectory. A variable structure guidance law is designed firstly. On the basis of it, a variable structure guidance law with spiral maneuver is proposed, in order to realize the large airspace spiral maneuver trajectory. The simulation results show that the proposed guidance law can guide the supersonic anti-warship missile to realize the large airspace spiral maneuver trajectory. The entire missiles performance indexes satisfy the flight requirement.