REPERFUSION INJURY AND INTRA-ABDOMINAL HYPERTENSION SYNDROME IN PATIENTS WITH ACUTE PANCREATITIS: CAUSES, CURRENT APPROACHES TO PREVENTION AND TREATMENT (LITERATURE REVIEW)

The aim of the work is to analyze and summarize current data on the problem of reperfusion injury and intra-abdominal hypertension syndrome in patients with acute pancreatitis: the causes of their occurrence, approaches to their prevention and treatment. Results. The analysis is based on sources that were searched in scientometric databases Google Scholar, MedLine, Web of Science, Scopus for 2013-2019. Disorders of microcirculation are one of the factors influencing the development of acute pancreatitis, namely, stimulate the increase of pancreatic enzymes level, interstitial edema and infiltration by inflammatory response cells. On the other hand, ischemia can complicate the course of the disease with the development of ischemia-reperfusion syndrome and intra-abdominal hypertension. The analyzed data concerning the prevention and treatment of these syndromes in acute pancreatitis are contradictory, which does not allow to form a unified approach to the treatment of the above conditions. Conclusions. In order to reduce mortality in acute pancreatitis, it is important to study possible ways to prevent and further manage patients with acute pancreatitis, accompanied by reperfusion injury and intra-abdominal hypertension.