Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

10.3791/62317 ◽  
2021 ◽  
Author(s):  
Chelsea D. Landon ◽  
Gabriella Dancourt ◽  
Vivian Shing ◽  
Herman F. Staats
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
Intranasal Immunization ◽  
Maternal Immunization ◽  
New Zealand White Rabbits

Panting in small mammals: a comparison of two marsupials and the laboratory rabbit

1977 ◽  
Vol 42 (4) ◽  
pp. 537-544 ◽  
Author(s):  
S. C. Nicol ◽  
M. Maskrey
Keyword(s):  
Oxygen Consumption ◽  
New Zealand ◽  
Rectal Temperature ◽  
Oryctolagus Cuniculus ◽  
Minute Volume ◽  
Evaporative Heat Loss ◽  
Thermoneutral Zone ◽  
New Zealand White Rabbits ◽  
Laboratory Rabbit ◽  
Potorous Tridactylus

By use of a barometric technique, tidal volume (VT), minute volume (VE), respiratory frequency (f), and respiratory evaporative heat loss (Eex) were measured from conscious unrestrained potoroos (Potorous tridactylus), barred bandicoots (Perameles gunnii), and New Zealand white rabbits (Oryctolagus cuniculus) at temperatures in and above the thermoneutral zone (TNZ). Rectal temperature (Tre) and oxygen consumption were also measured. VT initially decreased with rising Ta, but in the potoroo and rabbit it then increased past the resting level. VE increased much more in the marsupials than in the rabbit, and higher Eex maxima were also found for the marsupials. The marsupials had high Q10's above the TNZ, and had a panting efficiency of 80%. The rabbits had a Q10 of 1.9 above the TNZ and 100% panting efficiency. The high VE and Eex and low panting efficiency of the marsupials may be due to their lower Tre which allows transfer of heat from the environment to the animal.

Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus)

2019 ◽  
Vol 80 (10) ◽  
pp. 963-968
Author(s):  
Sarah M. Ozawa ◽  
Michelle G. Hawkins ◽  
Tracy L. Drazenovich ◽  
Philip H. Kass ◽  
Heather K. Knych
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
New Zealand White Rabbits

Pharmacokinetics and safety of ceftiofur crystalline free acid in New Zealand White rabbits (Oryctolagus cuniculus)

2017 ◽  
Vol 78 (7) ◽  
pp. 796-803 ◽  
Author(s):  
Sara Gardhouse ◽  
David Sanchez-Migallon Guzman ◽  
Sherry Cox ◽  
Philip H. Kass ◽  
Tracy L. Drazenovich ◽  
...  
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
Free Acid ◽  
New Zealand White Rabbits

scholarly journals Continuous Rate Infusion of Ketamine Hydrochloride and Dexmedetomidine for Maintenance of Anesthesia during Laryngotracheal Surgery in New Zealand White Rabbits (Oryctolagus cuniculus)

2020 ◽  
Vol 59 (2) ◽  
pp. 176-185
Author(s):  
Lea J Sayce ◽  
Maria E Powell ◽  
Emily E Kimball ◽  
Patty Chen ◽  
Gary J Gartling ◽  
...  
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
Vocal Fold ◽  
Muscle Tone ◽  
In Vivo Model ◽  
Topical Lidocaine ◽  
New Zealand White Rabbits ◽  
Ketamine Hydrochloride ◽  
Rate Infusion

New Zealand white rabbits (Oryctolagus cuniculus) are an established in vivo model for the study of structural and functional consequences of vocal-fold vibration. Research design requires invasive laryngotracheal procedures, and the presence of laryngospasms or pain responses (or both) hinder phonation-related data collection. Published anesthesia regimens report respiratory depression and muscle tone changes and have been unsuccessful in mitigating autonomic laryngeal responses in our protocol. Infusion of ketamine hydrochloride and dexmedetomidine hydrochloride in pediatric medicine provides effective analgesia and sedation for laryngotracheal procedures including intubation and bronchoscopy; however, data evaluating the use of ketamine–dexmedetomidine infusion in rabbits are unavailable. This study reports a new infusion regimen, which was used in 58 male New Zealand white rabbits that underwent a nonsurvival laryngotracheal procedure to induce phonotraumatic vocal-fold injury. Animals were sedated by using ketamine hydrochloride (20 mg/kg IM) and dexmedetomidine (0.125 mg/kg IM). Maintenance anesthesia was provided by using continuous rate intravenous infusion of ketamine hydrochloride (343 μg/kg/min) and dexmedetomidine (1.60 μg/kg/min). A stable plane of anesthesia with no autonomic laryngeal response (laryngospasm) was achieved in 32 of the 58 rabbits (55%). Laryngospasms occurred in 25 of 58 animals (43%) and were controlled in 20 cases (80%) by providing 0.33 mL 2% topical lidocaine, incremental increase in infusion rate, or both. Continuous rate infusion of ketamine hydrochloride–dexmedetomidine with prophylactic topical lidocaine provides a predictable and adjustable surgical plane of anesthesia, with minimal confounding respiratory and autonomic laryngeal responses, during extended-duration laryngotracheal surgery in rabbits. This regimen should be considered as an alternative to injection maintenance for prolonged, invasive procedures.

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