scholarly journals IMMUNOLOGICAL DETERMINANTS AND THE SPREAD OF VIRAL INFECTION IN FACIAL NERVE PARALYSIS INDUCED BY HERPES SIMPLEX VIRUS IN MICE

1996 ◽  
Vol 99 (4) ◽  
pp. 544-551,639 ◽  
Author(s):  
NAOHITO HATO
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Facial Nerve ◽  
Viral Infection ◽  
Facial Nerve Paralysis ◽  
Nerve Paralysis ◽  
Simplex Virus

Facial Nerve Paralysis Induced by Herpes Simplex Virus in Mice: An Animal Model of Acute and Transient Facial Paralysis

1995 ◽  
Vol 104 (7) ◽  
pp. 574-581 ◽  
Author(s):  
Toshiaki Sugita ◽  
Yasuo Fujiwara ◽  
Shingo Murakami ◽  
Yoshinari Hirata ◽  
Naoaki Yanagihara ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Facial Nerve ◽  
Facial Paralysis ◽  
Bell’S Palsy ◽  
Facial Nerve Paralysis ◽  
Bell's Palsy ◽  
Vacuolar Degeneration ◽  
Nerve Paralysis ◽  
Simplex Virus

We have been the first to succeed in producing an acute and transient facial paralysis simulating Bell's palsy, by inoculating herpes simplex virus into the auricles or tongues of mice. The KOS strain of the virus was injected into the auricle of 104 mice and the anterior two thirds of the tongue in 30 mice. Facial paralysis developed between 6 and 9 days after virus inoculation, continued for 3 to 7 days, and then recovered spontaneously. The animals were painlessly sacrificed between 6 and 20 days after inoculation for histopathologic and immunocytochemical study. Histopathologically, severe nerve swelling, inflammatory cell infiltration, and vacuolar degeneration were manifested in the affected facial nerve and nuclei. Herpes simplex virus antigens were also detected in the facial nerve, geniculate ganglion, and facial nerve nucleus. The pathophysiologic mechanisms of the facial paralysis are discussed in light of the histopathologic findings, in association with the causation of Bell's palsy.

Pathophysiology of Facial Nerve Paralysis Induced by Herpes Simplex Virus Type 1 Infection

2002 ◽  
Vol 111 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Naohito Hato ◽  
Hisanobu Kisaki ◽  
Nobumitu Honda ◽  
Hirotaka Takahashi ◽  
Shingo Murakami ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Facial Nerve ◽  
Time Course ◽  
Bell’S Palsy ◽  
Facial Nerve Paralysis ◽  
Bell's Palsy ◽  
Nerve Paralysis ◽  
Simplex Virus

Herpes simplex virus type 1 (HSV-1) has been proven to be a cause of Bell's palsy; however, the underlying pathophysiology of the facial nerve paralysis is not fully understood. We established a mouse model with facial nerve paralysis induced by HSV-1 infection simulating Bell's palsy and investigated the pathophysiology of the facial nerve paralysis. The time course of the R1 latency in the blink reflex tests paralleled the recovery of the facial nerve paralysis well, whereas electroneurographic recovery tended to be delayed, compared to that of the paralysis; these responses are usually seen in Bell's palsy. On histopathologic analysis, intact, demyelinated, and degenerated nerves were intermingled in the facial nerve in the model. The similarity of the time course of facial nerve paralysis and the electrophysiological results in Bell's palsy and the model strongly suggest that the pathophysiological basis of Bell's palsy is a mixed lesion of various nerve injuries.

Effects of acyclovir on facial nerve paralysis induced by herpes simplex virus type 1 in mice

2003 ◽  
Vol 30 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Hirotaka Takahashi ◽  
Naohito Hato ◽  
Nobimitsu Honda ◽  
Hisanobu Kisaki ◽  
Hiroyuki Wakisaka ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Facial Nerve ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Facial Nerve Paralysis ◽  
Nerve Paralysis ◽  
Simplex Virus

An Experimental Study of Facial Nerve Paralysis Induced by Reactivation of Herpes Simplex Virus Type-1

2002 ◽  
Vol 23 (Sup 1) ◽  
pp. S15-S16
Author(s):  
Hisanobu Kisaki ◽  
Hirotaka Takahashi ◽  
Nobumitsu Honda ◽  
Hiroyuki Wakisaka ◽  
Naohito Hato ◽  
...  
Keyword(s):  
Experimental Study ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Facial Nerve ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Facial Nerve Paralysis ◽  
Nerve Paralysis ◽  
Simplex Virus

Diabetic Mice Show an Aggravated Course of Herpes-Simplex Virus–Induced Facial Nerve Paralysis

2012 ◽  
Vol 33 (8) ◽  
pp. 1452-1457 ◽  
Author(s):  
Shinichi Esaki ◽  
Koji Yamano ◽  
Jun Kiguchi ◽  
Sachiyo Katsumi ◽  
Sumru Keceli ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Facial Nerve ◽  
Facial Nerve Paralysis ◽  
Diabetic Mice ◽  
Nerve Paralysis ◽  
Simplex Virus
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