Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience

Advances in Preventive Medicine ◽

10.4061/2011/846756 ◽

2011 ◽

Vol 2011 ◽

pp. 1-17 ◽

Author(s):

Jacqueline M. Miller ◽

Narcisa Mesaros ◽

Marie Van Der Wielen ◽

Yaela Baine

Keyword(s):

Global Health ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Type B ◽

Conjugate Vaccines ◽

Age Related ◽

New Vaccines ◽

Infants And Young Children

Meningococcal diseases are serious threats to global health, and new vaccines specifically tailored to meet the age-related needs of various geographical areas are required. This paper focuses on the meningococcal conjugate vaccines developed by GSK Biologicals. Two combined conjugate vaccines were developed to help protect infants and young children in countries where the incidence of meningococcal serogroup C or serogroup C and Y disease is important: Hib-MenC-TT vaccine, which offers protection againstHaemophilus influenzaetype b andNeisseria meningitidisserogroup C diseases, is approved in several countries; and Hib-MenCY-TT vaccine, which addsN. meningitidisserogroup Y antigen, is currently in the final stages of development. Additionally, a tetravalent conjugate vaccine (MenACWY-TT) designed to help protect against four meningococcal serogroups is presently being evaluated for global use in all age groups. All of these vaccines were shown to be highly immunogenic and to have clinically acceptable safety profiles.

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IMMEDIATE AND LONGER TERM IMMUNOGENICITY OF A SINGLE DOSE OF THE COMBINED HAEMOPHILUS INFLUENZAE TYPE B-NEISSERIA MENINGITIDIS SEROGROUP C-TETANUS TOXOID CONJUGATE VACCINE IN PRIMED TODDLERS 12 TO 18 MONTHS OF AGE

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0b013e31820013d2 ◽

2011 ◽

Vol 30 (4) ◽

pp. 340-342 ◽

Author(s):

Robert Booy ◽

Peter Richmond ◽

Terry Nolan ◽

Jodie McVernon ◽

Helen Marshall ◽

...

Keyword(s):

Single Dose ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Tetanus Toxoid ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

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Changes in Hospitalizations for Pneumonia After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13 Valent and Haemophilus influenzae Type b Conjugate Vaccine in a Pediatric Referral Hospital in Uruguay

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0000000000000294 ◽

2014 ◽

Vol 33 (7) ◽

pp. 753-759 ◽

Author(s):

María Catalina Pírez ◽

Gabriela Algorta ◽

Flavia Chamorro ◽

Claudia Romero ◽

Adriana Varela ◽

...

Keyword(s):

Haemophilus Influenzae ◽

Conjugate Vaccine ◽

Universal Vaccination ◽

Referral Hospital ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

Type B ◽

Conjugate Vaccines ◽

Pneumococcal Conjugate Vaccines

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Five-year Antibody Persistence and Safety After a Single Dose of Combined Haemophilus influenzae Type B Neisseria meningitidis Serogroup C–Tetanus Toxoid Conjugate Vaccine in Haemophilus influenzae Type B-primed Toddlers

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0000000000000898 ◽

2015 ◽

Vol 34 (12) ◽

pp. 1379-1384 ◽

Author(s):

Robert Booy ◽

Terry Nolan ◽

Graham Reynolds ◽

Peter Richmond ◽

Michael Nissen ◽

...

Keyword(s):

Single Dose ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Tetanus Toxoid ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

Type B ◽

Antibody Persistence

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IMMUNOGENICITY IN INFANTS OF HAEMOPHILUS INFLUENZAE TYPE B POLYSACCHARIDE IN A CONJUGATE VACCINE WITH NEISSERIA MENINGITIDIS OUTER-MEMBRANE PROTEIN

10.1016/s0140-6736(86)90001-2 ◽

1986 ◽

Vol 328 (8502) ◽

pp. 299-302 ◽

Author(s):

MenachemS Einhorn ◽

EdwinL Anderson ◽

GeoffreyA Weinberg ◽

PaulD Granoff ◽

DanM Granoff

Keyword(s):

Membrane Protein ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Outer Membrane ◽

Conjugate Vaccine ◽

Outer Membrane Protein ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

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Clinical experience with PedvaxHIB, a conjugate vaccine of Haemophilus influenzae type b polysaccharide—Neisseria meningitidis outer membrane protein

Vaccine ◽

10.1016/0264-410x(91)90180-e ◽

1991 ◽

Vol 9 ◽

pp. S38-S41 ◽

Author(s):

V.I. Ahonkhai ◽

L.J. Lukacs ◽

L.C. Jonas ◽

G.B. Calandra

Keyword(s):

Membrane Protein ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Outer Membrane ◽

Conjugate Vaccine ◽

Clinical Experience ◽

Outer Membrane Protein ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

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Five-year antibody persistence and safety following a booster dose of combined Haemophilus influenzae type b-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine

The Pediatric Infectious Disease Journal ◽

10.1097/inf.0b013e318269433a ◽

2012 ◽

pp. 1 ◽

Author(s):

Juan Carlos Tejedor ◽

José Manuel Merino ◽

Manuel Moro ◽

Maria-Luisa Navarro ◽

José Espín ◽

...

Keyword(s):

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Tetanus Toxoid ◽

Booster Dose ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

Type B ◽

Antibody Persistence

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MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine.

Infection and Immunity ◽

10.1128/iai.65.5.1710-1715.1997 ◽

1997 ◽

Vol 65 (5) ◽

pp. 1710-1715 ◽

Author(s):

D M Granoff ◽

Y E McHugh ◽

H V Raff ◽

A S Mokatrin ◽

G A Van Nest

Keyword(s):

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Antibody Responses ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

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Faculty Opinions recommendation of Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717962180.793465807 ◽

2012 ◽

Author(s):

Susan Coffin

Keyword(s):

Single Dose ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Tetanus Toxoid ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

Type B ◽

Antibody Persistence

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Faculty Opinions recommendation of A combined Haemophilus influenzae type B Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when coadministered with diphtheria, tetanus, acellular pertussis hepatitis B-inactivated poliovirus at 3, 5 and 11 months of age: results of an open, randomized, controlled study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717969130.793469931 ◽

2013 ◽

Author(s):

Susan Coffin

Keyword(s):

Hepatitis B ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Tetanus Toxoid ◽

Haemophilus Influenzae Type ◽

Controlled Study ◽

Haemophilus Influenzae Type B ◽

Type B ◽

Randomized Controlled

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The development of a new heptavalent diphtheria–tetanus–whole cell pertussis–hepatitis B–Haemophilus influenzae type b–Neisseria meningitidis serogroups A and C vaccine: a randomized dose-ranging trial of the conjugate vaccine components

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2007.08.007 ◽

2008 ◽

Vol 12 (3) ◽

pp. 278-288 ◽

Author(s):

S. Gatchalian ◽

E. Palestroque ◽

I. De Vleeschauwer ◽

H.H. Han ◽

J. Poolman ◽

...

Keyword(s):

Hepatitis B ◽

Haemophilus Influenzae ◽

Neisseria Meningitidis ◽

Conjugate Vaccine ◽

Haemophilus Influenzae Type ◽

Haemophilus Influenzae Type B ◽

Type B ◽

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