scholarly journals Implication of enterohepatic re-circulation on single dose bioequivalence evaluation of two brands of clonidine hydrochloride tablets in healthy human volunteers

2009 ◽  
Vol 71 (5) ◽  
pp. 515 ◽  
Author(s):  
HR Mehta ◽  
IK Patel ◽  
NH Patel ◽  
DM Patel ◽  
AB Parmar
Keyword(s):  
Single Dose ◽  
Healthy Human ◽  
Human Volunteers ◽  
Clonidine Hydrochloride

scholarly journals Comparative Bioavailabilitv Studv of Two Brands of Terbutaline Sulphate Tablets in Healthy Human Volunteers

2004 ◽  
Vol 72 (3) ◽  
pp. 227-237
Author(s):  
Nahla S. Barakat ◽  
Nawal M. Khalafallah ◽  
Said A. Khalil
Keyword(s):  
Single Dose ◽  
Reference Product ◽  
Hplc Method ◽  
Fasting State ◽  
Unchanged Drug ◽  
Healthy Human ◽  
Terbutaline Sulphate ◽  
Human Volunteers

The purpose of this study was to evaluate the bioavailability of locally produced 2.5 mg terbutaline sulphate tablets (brand A ) relative to a reference product, Bricanyl 2.5 mg tablets (brand 6). The study was a single dose 5 mg randomized crossover one in 15 healthy volunteers in the fasting state. Urine was collected at intervals of 24 h. Total terbutaline excreted in urine as unchanged drug and as conjugates (sulphate and glucuronide) was determined by a developed and validated HPLC method. In-vitro characteristics of both brands were similar. Based on percent of the dose excreted in urine, the oral bioavailability ranged from 33.5% to 75.8% for both brands. Statistics were applied to judge bioequivalence according to USP 24 in-vivo bioequivalence guidance. Results indicated that brand A and B were bioequivalent and hence interchangeable in medical practice.

The effects of an investigational antimalarial agent, NIPRD-AM1 on the single dose pharmacokinetics of metronidazole in healthy human volunteers

2010 ◽  
Vol 35 (3-4) ◽  
pp. 103-108 ◽  
Author(s):  
Obiageri O. Obodozie ◽  
Benjamin U. Ebeshi ◽  
Kudirat B. Mustapha ◽  
Rukaiyatu A. Kirim ◽  
Margaret Ekpenyong ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Human ◽  
Antimalarial Agent ◽  
Human Volunteers
Sign in / Sign up

Export Citation Format

Share Document