International Research Journal of Pharmacy
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1989
(FIVE YEARS 1266)

H-INDEX

11
(FIVE YEARS 5)

Published By Moksha Publishing House

2230-8407
Updated Thursday, 21 October 2021

2021 ◽  
Vol 12 (9) ◽  
pp. 1-5
Author(s):  
Biraj Jung Khadka ◽  
Madhushree H S ◽  
Ganesh Puttur

Basti Chikitsa is a prime treatment modality among the Panchakarma. It has not only curative aspects but also preventive and promotive aspects. Basti is the prime treatment for vata dosha but is also useful for the diseases caused by pitta dosha, kapha dosha as well as rakta and their combinations. Different permutations and combinations of basti dravyas give the wide option for the physician to treat all categories of diseases in all the age groups. Unlike Vamana and Virechana, Basti can be administered in all the age groups & can be administered in all the stages & variety of diseases. According to the pharmacokinetics it is also proven that rectal drugs administration might exceed the oral value due to partial avoidance of hepatic first pass metabolism. More than 500 million neurons are present in the ENS (Enteric Nervous System) and hence it is called “second brain”. Basti may act over the receptors of the ENS to stimulate the CNS causing secretion of required hormones or other chemicals. This article evaluates the validity and importance of Basti being termed as Ardha chikitsa or Sampoorna chikitsa.


2021 ◽  
Vol 12 (9) ◽  
pp. 33-38
Author(s):  
Reeny Ravina Dias ◽  
Madhushree HS ◽  
Ganesh Puttur

Niruha Basti (therapeutic decoction enema) is one of the important Panchakarma procedures (five internal bio-cleansing procedures) which is the best treatment modality in the diseases caused due to not only Vata, but also when associated with other Doshas as well. The preparation of Niruha Basti comprises of step wise mixing of ingredients as described in the Ayurveda classics. In the present study, simple Erandamoola Niruha Basti was prepared by adding Madhu (honey), Saindhava (rock salt), Moorchita Tila Taila (medicated sesame oil), Shatapushpa Kalka (paste of Athenum sowa) and Erandamoola Kwatha (decoction of root of Ricinus communis) in classical method to assess the changes in particle size distribution in each step of preparation at specific intervals. The changes taken place during the Bhavana of the ingredients was observed under microscope. The Erandamoola Niruha Basti was prepared in classical method as well as contemporary methods like churner, mixer, etc., to assess the emulsion stability. Another Erandamoola Niruha Basti was also prepared replacing Madhu (honey) with egg yolk to check for emulsion stability and particle size & distribution.


2021 ◽  
Vol 12 (9) ◽  
pp. 27-32
Author(s):  
Shah Esha Bhavin ◽  
Gajjar Anuradha

The application of the ratio spectra derivative spectrophotometry to the simultaneous determination of Paracetamol (PCM) and Tapentadol (TAP) in combined pharmaceutical tablets is presented. The spectrophotometric procedure is based on the use of the first derivative of the ratio spectra obtained by dividing the absorption spectrum of the binary mixtures by a standard spectrum of one of the compounds. The first derivative amplitudes were measured at 220 and 232 nm for the assay of TAP and PCM, respectively. Calibration graphs were established for 1-5 μg mL-1 for TAP and 6.5-32.5 μg mL-1 for PCM in binary mixture. The detection limits for TAP and PCM were found 0.098 and 0.595 μg mL-1, respectively, while the quantification limits were 0.298 μg mL-1 for TAP and 1.805 μg/ml for PCM. The relative standard deviations were found to be less than 2%, indicating reasonable repeatability of both methods. The proposed methods were hence validated as per ICH guidelines and successfully applied to the determination of these drugs in commercial tablets.


2021 ◽  
Vol 12 (9) ◽  
pp. 6-20
Author(s):  
Rabnoor Alam ◽  
Kamini . ◽  
Aastha Arora ◽  
Harsh Gupta ◽  
Pankaj Kumar Sharma

The transdermal patches are used to deliver medication through the skin to treat the entire ailment. These depend on a unique size property of skins to encoded drugs solid lipid nanoparticles (SLNs) current a chance to create upon novel therapeutic properties used for drugs transmission SLN targeting holds great potential for target achieving, a penalty area, Many aspects of the loaded of SLN sin transdermal patches for increasing mechanism of penetration, formulation, characterization parameters, future advantages, limitations of SLNs, had better biocompatibility, low harmfulness, SLNs is physically stable, and better delivery for Lipophilic drugs are discussed here. SLNs are a hybrid of liposomes and polymer-based carriers that could be used to encapsulate both lipid and water-soluble medicines. SLN is a low-cost product that can be scaled up. They also have a long-life span and could be customized by using different lipids. Because of their multiple significant qualities, SLNs also started to emerge when effective drug delivery carriers, as well as the prospect with liposome delivery of drugs, depends heavily on them. Many patents relating to SLNs have already been submitted, there are more invented SLN-based delivery systems on the way soon.


2021 ◽  
Vol 12 (9) ◽  
pp. 21-26
Author(s):  
Haripriya Vasudev ◽  
Madhushree HS ◽  
Ganesh Puttur

Lifestyle changes have contributed a lot in the manifestation and exacerbation of different disorders. Diseases can be prevented by doing nidana parivarjana, dinacharya, ritucharya, following sadvritta and following ashta ahara vidhi ayatana. Ritu shodhana will help to promote health and prevent the onset of diseases and also by doing the nidana parivarjana which will help to prevent the onset of diseases. Shodhana is an effective tool to prevent the lifestyle diseases also. This article will explain about the preventive measures of lifestyle disorders through Ayurvedic principles.


2021 ◽  
Vol 12 (8) ◽  
pp. 41-45
Author(s):  
K.P. Beena

Resistance to bacteria is a growing threat to human health worldwide. The rate of discovery of new antibacterial is far outshined by the rate at which resistance is spreading. Therefore, there remains a pressing need for the development of new antibacterial drugs. Recent alarm estimates that deaths due to antimicrobial resistance may increase from 700,000 million lives annually by 2050. Glucosamine-6-phosphate (GlcN-6-P) synthase represents an interesting protein target because it plays an essential role in the protection of cell wall. The primary aim and objective of this study is to identify lead molecules as promising antibacterial agents by inhibiting Glucosamine-6-phosphate (GlcN-6-P) synthase enzyme. Autodock 4. 2, the effective tool for exploring the binding affinity of small molecule to enzyme target was used to study the interactions between the oxazine derivatives and the GlcN-6-P synthase binding site. The ligands were optimized for improving their efficacy and safety. Lead optimization was performed using Molinspiration server and the ligands were optimized for evaluating their oral bioavailability. With Glucosamine 6 phosphate synthase receptor, the binding energy was found to be best for 5 compounds SZ-3 (-5.27 kcal/mol), SZ-4 (-6.02 kcal/mol), SZ-5 (-5.35 kcal/mol), SZ-8 (-5.62kcal/mol), SZ-10 (-5.29 kcal/mol) when compared to the standard ligand, Ciprofloxacin (-5.09 kcal/mol) and were interacting well with the key residues TYR 304, GLU 438, LEU 484. Docking study strongly enhanced the activity of oxazine derivatives as new discovered hits.


2021 ◽  
Vol 12 (8) ◽  
pp. 46-51
Author(s):  
Jeetendra Kushwaha ◽  
Dev Sharan Chaturvedi ◽  
Manisha Verma ◽  
Kuldeep Kumar Tiwari ◽  
Neelesh Anuragi

Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Trazodone Hydrochloride (TRZ) is a well-known chemical compound that is used as an antidepressant that belongs to a selective serotonin reuptake inhibitor (SARI). The objective of present work was to develop and evaluated oral sustained release matrix tablet of TRZ. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. No interactions were observed between TRZ and excipients from the Fourier transform infrared spectroscopy. The present research work was successful in improving the efficacy TRZ oral therapy as the drug release was extended for 12 hours thus reducing dosing frequency thereby improving patient compliance. The study also revealed the applicability of HPMC K-15, Gaur gum and PVP K30 as rate-controlling polymers in matrix tablets. The hydrophilic matrix of HPMC alone cannot control the release TRZ effective for 12 h while when combined with guar gum, may slow down the release of the drug and therefore, can be successfully employed for the formulation of matrix tablets SR. It may be concluded from the study that; the optimized formulation F-8 was shown maximum drug release 99.12 % in 12 h of dissolution. The release kinetic data of formulation F-8 shown first order release kinetics (R2 = 0.980).


2021 ◽  
Vol 12 (8) ◽  
pp. 58-63
Author(s):  
V. Manikandan

The dosage form of parenteral is sterile and gives a quick beginning of activity and gives an immediate action to accomplishing the medication impact inside the body. The route of parenteral administration is the most well-known and productive route for the conveyance of dynamic medication substances with poor bioavailability and medications with a tight therapeutic index. The principal objective of the technique was to endeavour to talk about the different procedures needed for the pilot plant production considers. The pilot plant is the term that is normally more modest than large-scale production plants yet it is the underlying scope of sizes. It is planned for learning, and making the definitions on a limited scale to accomplish the relationship with the enormous scope production, and they are normally more adaptable perhaps to the detriment of the economy. Most of the pilot plants are implicit in the maker's own research centres of the manufacturer utilizing stock lab hardware. These pilot plant studies are performed by using a technology transfer (TT) documentation report which is made by the research and development department for product development. Hence, this process would meet product quality, safety, and efficacy and further this production techniques will transfer to large-scale production for parenteral preparation.


2021 ◽  
Vol 12 (8) ◽  
pp. 32-40
Author(s):  
Canberk Yılmaz ◽  
Cüneyt Toprak ◽  
Gökay Gün

Sodium Alginate Sodium Bicarbonate Calcium Carbonate combination reduces heartburn, heartburn or stomach complaints caused by reflux. The aim of this study is to create sodium alginate sodium bicarbonate calcium carbonate combination formulation using pre-development devices such as Turbiscan Tower and Zeta Potential. In order to obtain a homogeneous mixture during production and pilot study using two different boiler 5 trial production, samples will be pre-feasibility devices (Turbiscan Tower and Zeta Potential) stress conditions using physical behaviors have been observed.


2021 ◽  
Vol 12 (8) ◽  
pp. 52-57
Author(s):  
Chaitali R Dhale ◽  
Rao J R

A simple and specific stability indicating reversed-phase high-performance liquid chromatography technique has been developed and validated for the concurrent estimation of metformin hydrochloride and dapagliflozin in bulk and pharmaceutical dosage form. The ideal conditions were established for the study or analysis of the drug such as chromatographic separation was carried out on THERMO fisher ODS C18 column containing mobile phase of water and acetonitrile 65:35 % v/v of pH 6.8 adjusted with 0.1 % ortho phosphoric acid at a flow rate of 1 ml/minutes detected wavelength at 240 nm. The retention time was found to be 2.13 minutes and 5.41 minutes for metformin hydrochloride (MET) and dapagliflozin (DAPA) respectively. The proposed method was found to be linear in the concentration range of 100-600 ug/ml for MET (R2=0.9999) and 1-6 ug/ml for DAP (R2=0.9996), respectively. Method was validated according to ICH guidelines. Co-relation coefficients for both the drugs were found to be less than one. The mean % recoveries obtained were found to be 99.06-100.32% for metformin and 99.1-100.18% for dapagliflozin respectively. Stress testing is carried out for both drugs in acid, base, peroxide, photolytic and thermal degradation. The developed method can be effectively applied for routine analysis in simultaneous determination of metformin hydrochloride and dapagliflozin in bulk and combined tablet dosage form.


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