International Research Journal of Pharmacy
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Published By Moksha Publishing House

2230-8407
Updated Monday, 31 May 2021

2021 ◽  
Vol 15 (5) ◽  
pp. 21-24
Author(s):  
Kanchana Devi S ◽  
Rajkumar G

The necessary element of non-public protecting instrumentation is mask. Mask is most necessary in pandemic as a result it safeguard our life by stopping the spreading of the Corona virus by entrapping the droplets from the corona affected person to enter wearer’s nose. There are different typed of mask like non- woven mask, reusable mask, N95 mask and artifact mask etc. Majority of business masks are non-woven masks that are created from polypropylene fiber. The most downside of non-woven masks is its discomfort and affect lack of breathability. This drawback is solved by utilizing natural fibers collectively of the material in non-woven and victimization them in mask. Bamboo fiber may be a natural celluloid fiber having smart comfort properties with antimicrobial properties. Bamboo fiber is also hydroscopic, natural deodorizer and hypoallergenic which provides good breathability and comfort. The polypropylene fiber is used with bamboo to provide good strength and abrasion property. Hence an attempt is made to develop a surgical mask from bamboo fiber with different blend ratios of 70:30, 60:40 and 50:50 of Bamboo and Polypropylene fiber to judge its mechanical properties like GSM and thickness potential as a protecting barrier material in non-woven face masks. The developed non-woven fabric of different blend is compared with each other, and the results shows 50: 50 blend has good mechanical properties, and the results show an effective value of Bacterial Filtration efficiency and Differential Pressure which are the most important parameters to predict the filtration efficiency of a surgical mask.


2021 ◽  
Vol 15 (5) ◽  
pp. 8-12
Author(s):  
Kajal Tomer ◽  
Dilip Kumar Gupta

The drug can be released in a controlled manner using a gastro retentive dosage type. The main focus on the novel technological advances in the floating drug delivery method for gastric retention. The preparation of diacerein micro balloon is done by solvent diffusion method, using acrylic polymer like Eudragit S 100 and HPMC K4 M. The various evaluation of the prepared floating microsphere like its % yield, drug entrapment efficiency, particle size in-vitro dissolution, buoyancy, was studied. The floating microsphere was found to be spherical and range from 85 μm - 192 μm. Whereas the buoyancy in gastric mucosa between the range 30.5% -49.5%. The % yield and % entrapment efficiency were found under the range 61% - 82% and 45.1–84.1% respectively. The microsphere showed favorable in-vitro dissolution 76.8 to 94.45. The optimized formulation was found based on evaluation of floating micro-balloons, Formulation (M3E3) showed the best result as particle size 192 μm, DDE 84.1%, in vitro drug release 94.5%, and in vitro buoyancy 49.5%. all the formulations showed controlled release up to 24 hours.


2021 ◽  
Vol 15 (5) ◽  
pp. 1-7
Author(s):  
Meenu Kumari ◽  
Monika Sachdeva ◽  
Vijay Agarwal

This research project is aimed to prepare improved topical preparation of Calcipotriol in the treatment of psoriasis by incorporation of an anti-inflammatory agent, keratolytic agent, humectants, surfactant, thickener & to perform its evaluation. In these different preparations of lotions sodium carboxymethylcellulose is used as a viscosity-enhancing agent in varying concentrations. This non-steroidal formulation is prepared by adding tea tree oil to avoid side effects associated with steroidal preparation and to avoid the issue of atrophy with long-term use of steroids. Evaluation of all the formulations such as spreadability, viscosity, drug content determination, pH, in-vitro release study, to choose the optimized formulation was carried out. According to ICH guidelines, stability studies were carried out to check the stability (parameters such as appearance, pH, viscosity, drug content) of prepared formulations for 3 months at room temperature. In-vitro drug release study CT5 formulation was carried by dialysis diffusion method. The cumulative% drug release of CT5 formulation in 210minutes was 85.10%. Based on the evaluation, formulation (CT5) was found to be better among all the formulations. The prepared calcipotriol formulation and a commercial formulation of calcipotriol were evaluated for anti-psoriatic activity. In-vivo anti-psoriatic was performed by using the Imiquimod Induced Psoriasis skin model. The results obtained in this study have been concluded that the prepared formulation (CT5) has great potential for topical delivery in the treatment of psoriasis.


2021 ◽  
Vol 15 (5) ◽  
pp. 13-20
Author(s):  
Namrata S Mane ◽  
Namrata A Muddalwar ◽  
Priya V Nikam ◽  
Narendra R Dighade

The aim was to formulate and evaluate fast dissolving tablets of diclofenac sodium to improve the bioavailability of the drug and patient compliance. Fast dissolving tablets of diclofenac sodium were prepared by direct compression method by using superdisintegrants (locust bean gum) in 2%, 3%, 4% 5% & 6% concentration respectively. Tablets were formulated by using natural superdisintegrants locust bean gum (LBG). This formulated mixture i.e., drug and LBG was mixed with other excipients and the tablets were compressed by direct compression. Formulated tablets were characterized by FTIR, pre-compression and post-compression parameters. The In vitro drug release studies were performed in pH 6.8 phosphate buffer. Formulated tablets were characterized by FTIR, the results of IR study showed that there was no interaction between superdisintegrant and pure drug, the results of FTIR study showed that drug was stable in the final formulated tablet. The drug content was evaluated with the help of assay. Five (F1-F5) formulations were evaluated for pre-compression and post-compression parameters and all the results were in the standard limits. Formulated dosage form may be an effective alternative to conventional dosage form which can be effectively used in the treatment of inflammation specially in cases of acute pain.


2021 ◽  
Vol 12 (4) ◽  
pp. 34-36
Author(s):  
Nikita D. Gidde ◽  
Priyanka V. Desai ◽  
Priyanka V. Bagade ◽  
Seema U. Shinde ◽  
Manojkumar M. Nitalikar

The main objective of developing a herbal hand sanitizer would be to promote "hand hygiene." It is a key element in the detection, control, and elimination of any acquired infection. Hand sanitizer will break the chain of microorganisms and other bacteria spreading from the hands to other areas of our bodies. Hand hygiene is essential and among the most common important steps in food processing, food service, and in the preparation of homes and other day care facilities. Hand sanitizer prevents itching, scratching, dermatitis, and other unpleasant side effects. So, maintaining hand hygiene as the key approach, an attempt to formulate an herbal hand sanitizer using extracts from widely available plants such as Argemone mexicana and Calendula officinalis, instead of a synthetic formulation. Physical parameters of the formulation were assessed. These ingredients, in combination, have seemed to act as an effective hand sanitizer.


2021 ◽  
Vol 12 (4) ◽  
pp. 23-33
Author(s):  
Prashant Kumar ◽  
Sunil Khatak

The aim of this dissertation work was to develop and characterize an optimal formulation of solid lipid nanoparticles of nadifloxacin, which would then be incorporated into hydrogel. The SLN was developed with drug nadifloxacin, which is poorly water soluble. On the basis of solubility studies (i.e. partitioning effects), the lipid and components were chosen. In this study, the two variables amount of lipid and concentration of Poloxamer 188 were studied. The EE increased as the concentration of Poloxamer 188 increased. The particle size was observed to decrease as the concentration of Poloxamer 188 was increased. The EE increased in a similar way as the amount of lipid was increased. So the purpose was to formulate hydrogel with carbopol 940 with improved drug entrapment, sufficient viscosity, good extrudability, good homogeneity and improved drug release. Hydrogels are polymers that have swelling ability in water or aqueous solvent systems. Due to their increased water content, gels can provide a better feeling for skin than other conventional dosage forms. Hydrogels are insoluble in water. They are not easily removed from the application site.


2021 ◽  
Vol 12 (4) ◽  
pp. 19-22
Author(s):  
S. Sarala ◽  
D. Chamundeeswari ◽  
V. Gopal

Pancha Harithakadi Churna (PHC) is a traditional polyherbal formulation meant for digestion which consists of household ingredients having digestive property. PHC is mainly used for Constipation and Bloating. Churna’s will play an important role in gastro intestinal problems. Churna’s are having greater bioavailability because of smaller particle size. It consists of fine powder (sieve 100 size) of Ginger rhizomes, Fennel fruits, Myrobalan fruits, Senna leaflets and Pink Rock salt in equal proportions (1:1:1:1:1) are mixed well. PHC is formulated by standard procedures and evaluated by physical and analytical methods. Physicochemical standards and heavy metals are found to be within the limits. PHC is found to be free from microbes. The PHC showed pronounced amylolytic activity and moderate lipolytic and proteolytic activity when compared with standard showing its efficacy for treating indigestion. In future we will carry out other digestive enzymes in vitro studies and also to carry out in vivo digestive studies.


2021 ◽  
Vol 12 (4) ◽  
pp. 8-18
Author(s):  
Ruchi Sengar ◽  
Ankita Tripathi ◽  
Ratnesh Mishra ◽  
Harjeet Gautam ◽  
Farheen Sharif ◽  
...  

Globally, Breast Cancer is mostly detecting in women’s due to family history, obesity, irregular menstruation, intake of alcohol/tobacco, etc. When uncontrollable grow of cells in breast which turns into cancer, occur at lobules or duct of breast. Various indications are seen like – appearance of lumps, swelling, size & color of breast is change, unusual discharge, etc. Breast cancer can be diagnosis by oneself by doing some physical activity and by advance modern technology can help to detect the cancerous cells. Mammography and Sonography is the initial diagnosing method to detect the cancer cells without any incision or inserting tools into the breast. Doctors or trained healthcare observe the tumor i.e. it’s benign or malignant after that screening model is use to confirmation of the tumor.


2021 ◽  
Vol 12 (4) ◽  
pp. 37-43
Author(s):  
Alpana . ◽  
Sunil Khatak

This research work aimed to “Formulation of tolnaftate (TNF) loaded NLCs emulgel using hot homogenization method followed by ultrasonication method for topical application. The various parameters such as concentration of solid lipid (GMS), liquid lipid (Gelucire 44/14), and the concentration of gelling agent (Carbopol 940) were studied for particle size, zeta potential, %EE, and Viscosity of emulgel. The optimized formulation (F6) was found to be spherical in shape with a mean particle size of 104.8±44.30nm and zeta potential -33.0mV. The maximum % entrapment of tolnaftate in the optimized formulation was found to be 98.23±0.963. The in vitro drug release study demonstrated that the release of the drug from TNF-NLCs emulgel was shown in comparison to marketed formulation (KT5DERM) and pure TNF. Overall, the developed TNF-NLCs emulgel was considered as a potential anti-fungal nano-drug, providing a new direction to the fungal infection treatment.


2021 ◽  
Vol 12 (4) ◽  
pp. 1-7
Author(s):  
Raja Vidhya D ◽  
Girija S ◽  
Nila Ganamurali ◽  
Dhivya Dhanasekaran ◽  
Sarvesh Sabarathinam

Background: Cardiovascular complications are one of the leading causes of global mortality. Statins are intended to produce beneficial effects in reducing the risk of morbidity and mortality in cardiovascular patients. However, it becomes negligible in statin intolerant patients mainly due to muscle related symptoms. Objective: The objective of the study is to summarize the results of the studies available on safety and efficacy of bempedoic acid/ezetimibe combination treatment in statin intolerant patients. Methods: After comprehensive literature survey, in Cochrane Library, PubMed, Embase and Medline, randomized controlled studies involving statin intolerant hyperlipidemia, patients with low- density lipoprotein ≥200 mg/dl and at high risk of cardiovascular disease treated with Bempedoic acid and ezetimibe combination were selected. Results: For final quality analysis two clinical trials were selected to assess the safety and efficacy of the combination of Bempedoic acid and Ezetimibe. Data shows Bempedoic acid and Ezetimibe combination significantly lowered the low-density lipoprotein compared to the control groups (placebo vs Bempedoic acid vs ezetimibe). In addition, the data shows significant reduction in highly sensitive C- reactive protein, non-high density lipoprotein cholesterol, total cholesterol and apolipoprotein B. Conclusion: Overall, we conclude that the combination of Bempedoic acid and Ezetimibe can be considered as a treatment of choice for the treatment of hyperlipidemia for patients with statin-intolerance or maximally tolerated even to low-dose statins.


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