scholarly journals Does meconium contaminated amniotic fluid affect intestinal wall thickness and functional outcome in patients with anterior abdominal wall defects?

2022 ◽  
Vol 19 (1) ◽  
pp. 46
Author(s):  
Melanie Kapapa ◽  
Teresa Rieg ◽  
Alexandre Serra
2019 ◽  
Author(s):  
Melanie Kapapa ◽  
Teresa Rieg ◽  
Alexandre Serra

Abstract Background: We analysed abdominal wall defect patients over an 11-year period, aiming to assess the influence of meconium-contaminated amniotic fluid . Meconium-contaminated amniotic fluid leading to intestinal wall thickness and impairs surgical and functional outcome. Methods: A retro- and prospective, observational case- control design was used to compare gastroschisis (n=36) and omphalocele (n=18) children. Physical data, color of amniotic fluid, pre- and perinatal problems, operative complications and surgical technique, postoperative complications, duration of ICU stay, mechanical ventilation, parenteral nutrition, begin of oral feeding and total hospital stay were collected. Data was analyzed with descriptive methods, t-test and non-parametric tests such as Wilcoxon and Kruskal-Wallis were performed in addition to ANOVA, including post-hoc testing accepting a confidence interval of 95% (p<0.05) by using IBM SPSS software, version 23 (IBM, Illinois, USA). Results: Rate of meconium-contaminated amniotic fluid is significantly higher in GS compared to OC, delivery problems are also significantly higher, this yields in significantly more bowel loops anomalies and problems during surgery but had no significant influence on primary abdominal wall closures rate. The post-surgical outcome of OC was significantly better compared to GS. Within the GS, those with swollen intestines had significantly longer ICU stays due to extended mechanical ventilation, parenteral nutrition and delayed initiation of oral feeding. Same results were found for secondary closures compared to primary abdominal wall closures in GS group. Conclusions: Worsen functional short-term outcome of GS children was directly addicted to meconium contamination of amniotic fluid due to swollen intestines and because of this more post-surgical problem including significantly extended hospital stay were observed.


1995 ◽  
Vol 7 (3) ◽  
pp. 109-127 ◽  
Author(s):  
Hratch L Karamanoukian ◽  
Stuart J O'Toole ◽  
Philip L Glick

Improvements in anaesthetic care and postoperative management over the last two decades have significantly improved survival of neonates with ventral abdominal wall defects, from a dismal 47% in 1971, to 96% for both gastroschisis and isolated omphalocele in two recent series. This increased survival has generally been attributed to result from improvements in the pre and postoperative management of these fragile neonates. Specifically, the routine use of total parenteral nutrition, and staged repairs for cases with severe “viscero-abdominal disproportion” have been implicated in a decreased incidence of sepsis, morbidity and mortality. In addition, an appreciation of the wide spectrum of anomalies uniquely associated with gastroschisis and omphalocele have helped improve survival, as each has unique pathophysiologic features that have prognostic implications for the fetus before, during and after delivery.


2021 ◽  
Vol 100 (6) ◽  
pp. 53-59
Author(s):  
D.A. Plokhikh ◽  
◽  
D.E. Beglov ◽  
K.A. Kovalkov ◽  
◽  
...  

The objectives of this study were to determine the frequency and search for additional criteria for the diagnosis of visceroabdominal disproportion syndrome (VADS) in newborns with gastroschisis. Materials and methods of research: prospective controlled observational cross-sectional analytical study was carried out in 61 newborns with gastroschisis, admitted from June 2009 to July 2021. To search for the most significant factors indicating the presence of VADS, the following parameters were recorded in the studied patients: the size of the defect in the anterior abdominal wall, the composition of eventrated organs, the presence of a conglomerate of intestinal loops, the diameter of the intestinal tube, the thickness of the intestinal wall, the degree of visceroabdominal disproportion (VAD). Results: VAD was detected in 50 (82%) newborns with gastroschisis. In 10 (17%) cases, VAD was mild, in 27 (44%) – moderate, and in 13 (21%) patients – severe. A moderate direct relationship was found between the size of the anterior abdominal wall defect (r=0.29, p=0.022), intestinal tube diameter (r=0.56; p=0.001) and the severity of VAD. There was a strong direct correlation between the thickness of the intestinal wall, and the frequency and severity of VAD (r=0.93, p=0.001). A direct association was found between the presence of a conglomerate of intestinal loops in the eventrated organs and the frequency of VAD (p=0.002). There was no statistically significant relationship between the number of eventrated anatomical structures with the frequency and degree of VAD (p=0.36). Conclusion: to determine VADS, it is advisable to diagnose the following pathological conditions in patients with gastroschisis: thickening of the intestinal wall, dilatation of the intestinal tube, the presence of a conglomerate of tightly welded eventrated organs, the severity of which is directly proportional to the degree of disproportion.


1992 ◽  
Vol 65 (772) ◽  
pp. 298-301 ◽  
Author(s):  
S. A. Walkinshaw ◽  
M. Renwick ◽  
G. Hebisch ◽  
E. N. Hey

1972 ◽  
Vol 7 (5) ◽  
pp. 553-558 ◽  
Author(s):  
Arvin I. Philippart ◽  
Timothy G. Canty ◽  
Robert M. Filler

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