scholarly journals A rare case of cephalexin-induced acute interstitial nephritis with hypokalemic periodic paralysis

2020 ◽  
Vol 52 (3) ◽  
pp. 210
Author(s):  
Kavish Sharma ◽  
Rajesh Kumar ◽  
AmitKumar Singh ◽  
Vandana Talwar
CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A964
Author(s):  
Maarij Baig ◽  
Prateek Juneja ◽  
Nicole Baig ◽  
Kruti Ray

Author(s):  
C. McLoughlin ◽  
C. Cooney ◽  
R. Mullaney

We present a rare case of Acute Interstitial Nephritis (AIN) that occurred following a re-trial of clozapine in a 56-year-old lady with schizoaffective disorder. On initial trial of clozapine, this patient felt generally unwell with respiratory symptoms. Her inflammatory markers were raised and her renal function showed a mild, transient deterioration which normalised on the day of cessation of clozapine. Two years later, clozapine was re-trialled due the refractory nature of her psychiatric symptoms. She subsequently developed renal failure and AIN was confirmed by renal biopsy. Renal function improved after cessation of clozapine; however, she never fully regained normal renal function.


2016 ◽  
Vol 6 (6) ◽  
pp. 32976
Author(s):  
Atul Matta ◽  
Nour Abou Assalie ◽  
Rajib K. Gupta ◽  
Maria del Pilar Morales ◽  
Ricardo Conti

2020 ◽  
Vol 4 (1) ◽  
pp. 75-78 ◽  
Author(s):  
Michael Lajeunesse ◽  
Scott Young

Thyrotoxic hypokalemic periodic paralysis (THPP) is a condition that results in transient skeletal muscle paralysis secondary to intracellular potassium sequestration. Susceptible individuals often have an underlying channelopathy, which may be exacerbated by lifestyle factors or underlying medical comorbidities such as hyperthyroidism or diarrheal illness. Classically, THPP presents with paralysis of proximal extremity musculature. In this case, we present a rare case of unilateral THPP. Such a presentation is relevant to emergency physicians as it mimics a stroke or transient ischemic attack and should be considered on the differential for unilateral neurologic deficits.


Cureus ◽  
2021 ◽  
Author(s):  
Tahmina Jahir ◽  
S.M. Sadaf Hossain ◽  
Ruby Risal ◽  
Marie Schmidt ◽  
Danilo Enriquez ◽  
...  

Author(s):  
T. Shimizu ◽  
Y. Muranaka ◽  
I. Ohta ◽  
N. Honda

There have been many reports on ultrastructural alterations in muscles of hypokalemic periodic paralysis (hpp) and hypokalemic myopathy(hm). It is stressed in those reports that tubular structures such as tubular aggregates are usually to be found in hpp as a characteristic feature, but not in hm. We analyzed the histological differences between hpp and hm, comparing their clinical manifestations and morphologic changes in muscles. Materials analyzed were biopsied muscles from 18 patients which showed muscular symptoms due to hypokalemia. The muscle specimens were obtained by means of biopsy from quadriceps muscle and fixed with 2% glutaraldehyde (pH 7.4) and analyzed by ordinary method and modified Golgimethod. The ultrathin section were examined in JEOL 200CX transmission electron microscopy.Electron microscopic examinations disclosed dilated t-system and terminal cistern of sarcoplasmic reticulum (SR)(Fig 1), and an unique structure like “sixad” was occasionally observed in some specimens (Fig 2). Tubular aggregates (Fig 3) and honeycomb structure (Fig 4) were also common characteristic structures in all cases. These ultrastructural changes were common in both the hypokalemic periodic paralysis and the hypokalemic myopathy, regardless of the time of biopsy or the duration of hypokalemia suffered.


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