Respiratory Symptoms
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2021 ◽  
Vol In Press (In Press) ◽  
Gabriela Marengone Altizani ◽  
Karin Barszcz ◽  
Laura Cardoso Brentini ◽  
Karina Amelia Morikawa ◽  
Kelly Luisa Cintra ◽  

Introduction: Albeit most children infected with SARS-CoV-2 are asymptomatic or have mild respiratory symptoms, similar cases of Kawasaki disease and ç increased at the end of April 2020 worldwide. Systemic inflammatory involvement characterizes these cases and is part of the spectrum of a SARS-CoV-2-related syndromes called multisystem inflammatory syndrome (MIS-C). Case Presentation: We report the case of a child with severe cardiovascular impairment due to MIS-C who developed cardiogenic shock secondary to acute myocarditis. The pathophysiology of myocardial outcomes caused by MIS-C remains unclear. Conclusions: We intend to contribute to new prospective studies on the early diagnosis, clinical management, and follow-up of patients with severe cardiovascular impairment secondary to infection with SARS-CoV-2.

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 900
Diana C. Sanchez-Ramirez ◽  
Kaylene Normand ◽  
Yang Zhaoyun ◽  
Rodrigo Torres-Castro

Background: The long-term impact of COVID-19 is still unknown. This study aimed to explore post COVID-19 effects on patients chest computed tomography (CT), lung function, respiratory symptoms, fatigue, functional capacity, health-related quality of life (HRQoL), and the ability to return to work beyond 3 months post infection. Methods: A systematic search was performed on PubMed, Web of Science, and Ovid MEDLINE on 22 May 2021, to identify studies that reported persistent effects of COVID-19 beyond 3 months follow-up. Data on the proportion of patients who had the outcome were collected and analyzed using a one-group meta-analysis. Results: Data were extracted from 24 articles that presented information on a total of 5323 adults, post-infection, between 3 to 6 months after symptom onset or hospital discharge. The pooled prevalence of CT abnormalities was 59% (95% CI 44–73, I2 = 96%), abnormal lung function was 39% (95% CI 24–55, I2 = 94%), fatigue was 38% (95% CI 27–49, I2 = 98%), dyspnea was 32% (95% CI 24–40, I2 = 98%), chest paint/tightness was 16% (95% CI 12–21, I2 = 94%), and cough was 13%, (95% CI 9–17, I2 = 94%). Decreased functional capacity and HRQoL were found in 36% (95% CI 22–49, I2 = 97%) and 52% (95% CI 33–71, I2 = 94%), respectively. On average, 8 out of 10 of the patients had returned to work or reported no work impairment. Conclusion: Post-COVID-19 patients may experience persistent respiratory symptoms, fatigue, decreased functional capacity and decreased quality of life up to 6 months after infection. Further studies are needed to establish the extent to which post-COVID-19 effects continue beyond 6 months, how they interact with each other, and to clarify their causes and their effective management.

2021 ◽  
Vol 12 ◽  
Tyler Torrico ◽  
Timothy Kiong ◽  
Carlos D'Assumpcao ◽  
Uyi Aisueni ◽  
Fouad Jaber ◽  

Neuropsychiatric symptoms are a common complication of COVID-19, with symptoms documented both during acute COVID-19 infection (parainfectious) and persisting or developing after the resolution of respiratory symptoms (postinfectious). Patients have presented with a variety of symptoms such as anosmia, thrombotic events, seizures, cognitive and attention deficits, new-onset anxiety, depression, psychosis, and rarely catatonia. Etiology appears to be related to disruption of regular neurotransmission and hypoxic injury secondary to systemic inflammation and cytokine storm. Although rare, catatonia and each of its subtypes have now been reported as complications of COVID-19 and therefore should be considered known to occur in both the parainfectious and postinfectious states. Diagnosis of catatonia in the context of COVID-19 should be considered when work-up for more common medical causes of encephalopathy are negative, there is no identifiable psychiatric etiology for catatonia, and there is a positive response to benzodiazepines.

2021 ◽  
Vol 26 (3) ◽  
pp. 46-50
Kh. P. Derevyanko ◽  
L. N. Khusainova ◽  
M. M. Khafizov ◽  
A. Sh. Sattarova ◽  
Sh. M. Safin

The new coronavirus SARS-CoV-2 is a single-stranded RNA virus of the Coronaviridae family and is clinically manifest with respiratory symptoms. However, patients have been described with symptoms and complications from the nervous system, as well as skin manifestations in the form of various rashes. In our clinical case of coronavirus infection (SARS-CoV-2), this is pneumonia with respiratory failure of the 1st degree, moderate severity and Bell’s palsy in combination with skin rashes in the form of an urticarial rash in a 58-year-old woman. Clinical features of cutaneous and neurological symptoms were prior to the development of respiratory symptoms. The presented clinical case showed that COVID-19, before the development of respiratory symptoms, can manifest itself with peripheral paralysis of the facial nerve and be combined with skin rashes, which can complicate the timely diagnosis of a viral disease.

2021 ◽  
Vol 11 (7) ◽  
pp. 678
Bumhee Yang ◽  
Hayoung Choi ◽  
Sun Hye Shin ◽  
Youlim Kim ◽  
Ji-Yong Moon ◽  

Tuberculosis (TB) survivors experience post-TB lung damage and ventilatory function disorders. However, the proportions of obstructive and restrictive ventilatory disorders as well as normal ventilation among subjects with prior TB are unknown. In addition, the impacts of ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and the quality of life in subjects with prior TB remain unclear. Subjects who participated in the Korean National Health and Nutritional Examination Survey 2007–2016 were enrolled in this study. We evaluated the impact of each ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and quality of life (measured by the EuroQoL five dimensions questionnaire [EQ-5D] index values) in subjects with prior TB. Among 1466 subjects with prior TB, 29% and 16% had obstructive ventilatory disorders and restrictive ventilatory disorders, respectively. Mild and moderate obstructive ventilatory disorders were not associated with respiratory symptoms, physical activity limitations, or EQ-5D index value compared with normal ventilation; however, severe obstructive ventilatory disorders were associated with more respiratory symptoms (adjusted odds ratio [aOR] = 13.62, 95% confidence interval [CI] = 4.64–39.99), more physical activity limitation (aOR = 218.58, 95% CI = 26.82–1781.12), and decreased EQ-5D index (adjusted coefficient = −0.06, 95% CI = (−0.12–−0.10) compared with normal ventilation. Mild restrictive ventilatory disorders were associated with more respiratory symptoms (aOR = 2.10, 95% CI = 1.07–4.14) compared with normal ventilation, while moderate (aOR = 5.71, 95% CI = 1.14–28.62) and severe restrictive ventilatory disorders (aOR = 9.17, 95% CI = 1.02–82.22) were associated with physical activity limitation compared with normal ventilation. In conclusion, among subjects with prior TB, 29% and 16% developed obstructive and restrictive ventilatory disorders, respectively. Severe obstructive ventilatory disorder was associated with more respiratory symptoms, more physical activity limitation, and poorer quality of life, while severe restrictive ventilatory disorder was associated with more physical activity limitations.

Atmosphere ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 910
Niina Terunuma ◽  
Kazunori Ikegami ◽  
Hiroko Kitamura ◽  
Hajime Ando ◽  
Shizuka Kurosaki ◽  

There were errors in the original article [1] [...]

2021 ◽  
Vol 104 (7) ◽  
pp. 1214-1217

The authors report a case of a 32-year-old Thai woman with a COVID-19 infection that presented with urticaria and angioedema with a pityriasis rosea (PR)-like rash at a private hospital in Thailand. She presented at the hospital with bloody nasal discharge and diarrhea but without fever, myalgia, or any respiratory symptoms. She complained of angioedema and PR-like lesions on the third day of the treatment. Urticarial rash appeared intermittently for four weeks after all medications were discontinued, during which the patient had no fever, no respiratory symptoms, or any other symptoms. However, the RT-PCR results for COVID-19 RNA were positive during the time that the urticarial symptoms persisted. The COVID-19 RNA became negative on the fourth day after the last urticarial episode. Urticarial rash may be a clue that the inflammatory process is activated by COVID-19 virus after the treatment is completed. Keywords: Cutaneous; Pityriasis rosea; Angioedema; Urticaria; COVID-19

Sarah Ayad ◽  
Kirolos Gergis ◽  
Sherif Elkattawy ◽  
Noreen Mirza ◽  
Basel Abdelazeem ◽  

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical manifestations are diverse and can vary from mild respiratory symptoms to severe hypoxic respiratory failure. In severe cases, infection can cause gastrointestinal, renal, cardiac, neurological and haematological complications and result in multi-organ failure. There are very few reports of parapneumonic effusion in patients with COVID-19. We describe two patients with COVID-19 who had loculated empyema and discuss the clinical course and therapeutic options.

2021 ◽  
Vol 4 (7) ◽  
pp. e2117055
Lijun Wang ◽  
Jianjiu Chen ◽  
Lok Tung Leung ◽  
Zhi-Ming Mai ◽  
Sai Yin Ho ◽  

Jayshree Kharche ◽  
Deepak S. Khismatrao ◽  
Reshma Patil ◽  
Rajkumar Nikalje

Introduction: News published about persistence or reappearance of symptoms in Covid 19 is worrisome. However, only one study from Italy is observed in this reference. Aim: the current study is conducted to study persistence or reappearance of especially respiratory symptoms amongst COVID 19 hypoxia patients. Study Design: Post-discharge follow-up, observational study with the telephonic interview of Covid 19 hypoxia patients from a dedicated Covid 19 hospital in India. Methods: Sixty-two patients were interviewed 1 – 3 months post-discharge to elicit history on persistence or reappearance of respiratory symptoms. Results: out of the results many patients doesnot show any symptoms compared to female, male are more prone to respiratory problems. Thus, the oxygen therapy showed proof that males are more prone to illness and depict the symptoms compared to females. Conclusion: A large multi-centric year-long study is recommended to further conclude on the natural history of the disease.

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