A complex case of brown tumors as initial manifestation of primary hyperparathyroidism in a young female

Primary hyperparathyroidism (PHPT) is characterized with primary hyperproduction of parathyroid hormone (PTH) by affected parathyroid glands and with a corresponding increase in concentration of extracellular calcium. Long-term development of PHPT through decades leads to calcium-related symptoms and distinct changes in the skeleton, kidneys, digestive tract and other organs. In the clinical picture of PHPT, granulomatous pseudo-tumors in bones are observed as a rare manifestation of the disease – these lesions, which could imitate malignancy, are called «brown tumors». The present publication that goes into details about a clinical diagnosis, in which a brown tumor became the primary manifestation of PHPT, may be useful for physicians across various fields.

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Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Turkish Neurosurgery ◽

10.5137/1019-5149.jtn.4504-11.2 ◽

2011 ◽

Author(s):

Mahmoud Reza Khalatbari ◽

Mehrdokht Hamidi ◽

Yashar Moharamzad ◽

Ali Setayesh ◽

Abbas Amirjamshidi

Keyword(s):

Primary Hyperparathyroidism ◽

Skull Base ◽

Anterior Skull Base ◽

Review Of The Literature ◽

Initial Manifestation ◽

Brown Tumors

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Abstract #832: Primary Hyperparathyroidism Presenting as Haemorrhagic Stroke in a Young Female

Endocrine Practice ◽

10.1016/s1530-891x(20)45166-3 ◽

2016 ◽

Vol 22 ◽

pp. 178

Author(s):

Sachin Jain ◽

Anshuman Srivastava ◽

Ramesh Aggarwal ◽

Mahendra Rajput ◽

Nishchint Jain

Keyword(s):

Primary Hyperparathyroidism ◽

Haemorrhagic Stroke ◽

Young Female

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Abstract #529: Mccune-Albright Syndrome and Primary Hyperparathyroidism: An Unsusual Case Presenting with Coexisting Brown Tumors and Fibrous Dysplasia

Endocrine Practice ◽

10.1016/s1530-891x(20)44469-6 ◽

2017 ◽

Vol 23 ◽

pp. 115

Author(s):

Spandana Brown

Keyword(s):

Primary Hyperparathyroidism ◽

Fibrous Dysplasia ◽

Mccune Albright Syndrome ◽

Brown Tumors ◽

Albright Syndrome ◽

Mccune Albright

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Morphological and functional imaging allow better characterization of brown tumors in a patient with severe primary hyperparathyroidism

Endocrine Abstracts ◽

10.1530/endoabs.35.p276 ◽

2014 ◽

Author(s):

Lavinia Vija ◽

Diana Paun ◽

Gilles Grimon ◽

Frederique Archambaud ◽

Philippe Chaumet-Riffaud

Keyword(s):

Primary Hyperparathyroidism ◽

Functional Imaging ◽

Brown Tumors

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Brown tumors: the first and the final manifestation of primary hyperparathyroidism.

Endocrine Abstracts ◽

10.1530/endoabs.35.p294 ◽

2014 ◽

Author(s):

Joanna Sztembis ◽

Renata Orlowska-Florek ◽

Agata Dryja ◽

Grzegorz Swider

Keyword(s):

Primary Hyperparathyroidism ◽

Brown Tumors

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Severe bone disease caused by primary hyperparathyroidism: a case report and review of the literature

Journal of International Medical Research ◽

10.1177/0300060520966484 ◽

2020 ◽

Vol 48 (10) ◽

pp. 030006052096648

Author(s):

Yu Wang ◽

Jie Liu

Keyword(s):

Case Report ◽

Primary Hyperparathyroidism ◽

Bone Disease ◽

Distal Humerus ◽

Left Lobe ◽

Pathological Examination ◽

Hypoechoic Mass ◽

Brown Tumors ◽

Restricted Mobility ◽

The Right

Bone disease is an important complication of hyperparathyroidism. We herein report a rare case of severe bone disease caused by primary hyperparathyroidism. A 33-year-old man presented with pain and restricted mobility in his right upper limb and right hip due to a fall 3 days previously. X-ray examination showed a fracture of the proximal and distal humerus. Computed tomography examination showed a supracondylar fracture of the right humerus, a fracture of the right femoral neck, a fracture of the right sciatic branch, and multiple brown tumors. Ultrasonography showed a 3.5- × 1.6-cm hypoechoic mass below the left lobe of the thyroid. The patient was diagnosed with primary hyperparathyroidism based on increased serum calcium and parathormone concentrations, pathological fractures, and multiple brown tumors. He therefore underwent bilateral lower parathyroidectomy. Pathological examination revealed a parathyroid adenoma. The patient recovered well after surgery and was followed up for 6 months with no symptoms of hyperparathyroidism. This case report suggests that clinicians should be aware of the possibility of severe bone disease secondary to primary hyperparathyroidism. Active and early diagnosis and surgical treatment are important in such cases.

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