scholarly journals Local Protein Synthesis in Axonal Growth Cones

2007 ◽  
Vol 1 (4) ◽  
pp. 179-184 ◽  
Author(s):  
Saulius Satkauskas ◽  
Dominique Bagnard
Keyword(s):  
Protein Synthesis ◽  
Axonal Growth ◽  
Growth Cones ◽  
Local Protein Synthesis ◽  
Local Protein

scholarly journals Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones

2015 ◽  
Vol 10 (1) ◽  
pp. 3 ◽  
Author(s):  
Michael Piper ◽  
Aih Lee ◽  
Francisca van Horck ◽  
Heather McNeilly ◽  
Trina Lu ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Axonal Growth ◽  
Growth Cones ◽  
Microtubule Cytoskeleton ◽  
Local Protein Synthesis ◽  
Local Protein

scholarly journals Erratum to: Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael Piper ◽  
Aih Cheun Lee ◽  
Francisca P.G van Horck ◽  
Heather McNeilly ◽  
Trina Bo Lu ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Axonal Growth ◽  
Growth Cones ◽  
Microtubule Cytoskeleton ◽  
Local Protein Synthesis ◽  
Local Protein

scholarly journals Local protein synthesis of mtIF3 regulates mitochondrial translation for axonal development

2021 ◽  
Author(s):  
Soyeon Lee ◽  
Dongkeun Park ◽  
Chunghun Lim ◽  
Jae-Ick Kim ◽  
Kyung-Tai Min
Keyword(s):  
Axonal Growth ◽  
Growth Cones ◽  
Small Subunit ◽  
Bimolecular Fluorescence Complementation ◽  
Initiation Factor ◽  
Mitochondrial Translation ◽  
Local Protein Synthesis ◽  
Mitochondrial Ribosomes ◽  
Axonal Development ◽  
Local Protein

AbstractMitochondrial initiation factor 3 (mtIF3) binds to and dissociates mitochondrial ribosomes. The mtIF3-small subunit complex then recruits mtIF2, mRNA, and N-formylmethionine-tRNA to initiate mitochondrial translation. Intriguingly, transcripts of the nuclear-encoded mtIF3 gene have been shown present in axonal growth cones; however, the biological function of this compartmentalization remains largely unknown. Here, we demonstrate that brain-derived neurotrophic factor (BDNF) induces local translation of mtIF3 mRNA in axonal growth cones. Subsequently, mtIF3 protein is translocated into axonal mitochondria and promotes mitochondrial translation as assessed by our newly developed bimolecular fluorescence complementation sensor for the assembly of mitochondrial ribosomes. We further show that BDNF-induced axonal growth requires mtIF3-dependent mitochondrial translation in axons. These findings provide new insight into how neurons adaptively control mitochondrial physiology and axonal development via local mtIF3 translation.

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