Individual Differences in Stress Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis and Its Vasopressinergic Regulation in Old Monkeys

AbstractResearch suggests that early adversity places individuals at risk for psychopathology across the life span. Guided by concepts of allostasis and allostatic load, the present study examined whether early adversity contributes to the development of subsequent internalizing symptoms through its association with traitlike individual differences in hypothalamic–pituitary–adrenal axis regulation. Early adolescent girls (n= 113;Mage = 12.30 years) provided saliva samples at waking, 30 min postwaking, and bedtime over 3 days (later assayed for cortisol). Objective contextual stress interviews with adolescents and their mothers were used to assess the accumulation of nine types of early adversity within the family environment. Greater early adversity predicted subsequent increases in internalizing symptoms through lower levels of latent trait cortisol. Traitlike individual differences in hypothalamic–pituitary–adrenal axis activity may be among the mechanisms through which early adversity confers risk for the development of psychopathology.

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Individual differences in the activity of the hypothalamic pituitary adrenal axis: Relations to age and cumulative risk in early childhood

Psychoneuroendocrinology ◽

10.1016/j.psyneuen.2017.03.023 ◽

2017 ◽

Vol 81 ◽

pp. 36-45 ◽

Cited By ~ 8

Author(s):

Steven J. Holochwost ◽

Jean-Louis Gariépy ◽

W. Roger Mills-Koonce ◽

Cathi B. Propper ◽

Jacek Kolacz ◽

...

Keyword(s):

Early Childhood ◽

Individual Differences ◽

Cumulative Risk ◽

Hypothalamic Pituitary Adrenal Axis ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Pituitary Adrenal Axis

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Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation

Frontiers in Endocrinology ◽

10.3389/fendo.2013.00026 ◽

2013 ◽

Vol 4 ◽

Cited By ~ 46

Author(s):

Nadezhda D. Goncharova

Keyword(s):

Hypothalamic Pituitary Adrenal Axis ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Age Related ◽

Stress Responsiveness ◽

Pituitary Adrenal Axis

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Individual differences in the recovery of the hypothalamic–pituitary–adrenal axis after termination of exposure to a severe stressor in outbred male Sprague–Dawley rats

Psychoneuroendocrinology ◽

10.1016/s0306-4530(00)00060-3 ◽

2001 ◽

Vol 26 (4) ◽

pp. 363-374 ◽

Cited By ~ 12

Author(s):

A García

Keyword(s):

Individual Differences ◽

Hypothalamic Pituitary Adrenal Axis ◽

Sprague Dawley ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Sprague Dawley Rats ◽

Severe Stressor ◽

Pituitary Adrenal Axis

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Age-related differences in stress responsiveness of the hypothalamic-pituitary-adrenal axis of nonhuman primates with various types of adaptive behavior

General and Comparative Endocrinology ◽

10.1016/j.ygcen.2017.08.007 ◽

2018 ◽

Vol 258 ◽

pp. 163-172 ◽

Cited By ~ 6

Author(s):

Nadezhda D. Goncharova ◽

Tamara E. Oganyan

Keyword(s):

Adaptive Behavior ◽

Nonhuman Primates ◽

Hypothalamic Pituitary Adrenal Axis ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Age Related ◽

Stress Responsiveness ◽

Pituitary Adrenal Axis

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Reactivity and distortions in the self: Narcissism, types of aggression, and the functioning of the hypothalamic–pituitary–adrenal axis during early adolescence

Development and Psychopathology ◽

10.1017/s0954579409990149 ◽

2009 ◽

Vol 21 (4) ◽

pp. 1249-1262 ◽

Cited By ~ 19

Author(s):

William M. Bukowski ◽

Alex Schwartzman ◽

Jonathan Santo ◽

Catherine Bagwell ◽

Ryan Adams

Keyword(s):

Individual Differences ◽

Relational Aggression ◽

Early Adolescence ◽

Hypothalamic Pituitary Adrenal Axis ◽

The Self ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Response System ◽

Positive Experiences ◽

Pituitary Adrenal Axis

AbstractA multisample, multistudy project aimed at understanding how individual differences in narcissism during early adolescence are related to distortions in the aggression, and the reactivity of the hypothalamic–pituitary–adrenal axis to negative and positive experiences. The findings indicate that individual differences in narcissism are a remarkably stable aspect of personality during early adolescence. It is predictably related to an inflated view of the self that is not warranted by objective indices of social functioning. Further evidence shows that it promotes the continuity of aggressive behavior and is more strongly related to reactive aggression than to proactive aggression and more strongly related to relational aggression than to physical aggression. Finally, there is evidence that distortions in the self may derive from the inadequate functioning of the hypothalamic–pituitary–adrenal axis, one of the body's main response system for dealing with stress. These findings are discussed in terms of the processes by which early adolescents react to threats and arousal in their daily functioning.

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