Vascular responses to a biodegradable polymer (polylactic acid) based Biolimus A9-eluting stent in porcine models

Biodegradable polymer has been widely used in surgical suture, dressing, artificial bone and other bone-related applications. Studies have demonstrated that metals, such as titanium, titanium alloys or 316L stainless steel, can be widely used in dental and maxillofacial surgeries. The present study aimed to fabricate a scaffold with a blend of multilayer polylactic acid (PLA) ply yarns with 316L stainless steel (SS) braids, which was then immersed in simulated body fluid (SBF), forming the PLA/SS composite braid with hydroxylapatite deposition. After being immersed in SBF for 14 days, the PLA/SS composite braid was covered with precipitate which was confirmed to be apatite deposition according to surface observation and EDS evaluation.

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Polylactic acid - biodegradable polymer obtained from vegetable resources

Polimery ◽

10.14314/polimery.2002.769 ◽

2002 ◽

Vol 47 (11/12) ◽

pp. 769-774 ◽

Cited By ~ 3

Author(s):

ZENON FOLTYNOWICZ ◽

PATRYCJA JAKUBIAK

Keyword(s):

Polylactic Acid ◽

Biodegradable Polymer

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An optical coherence tomography study of two new generation stents with biodegradable polymer carrier, eluting paclitaxel vs. biolimus-A9

International Journal of Cardiology ◽

10.1016/j.ijcard.2010.12.072 ◽

2012 ◽

Vol 157 (3) ◽

pp. 341-346 ◽

Cited By ~ 15

Author(s):

Periklis A. Davlouros ◽

Eleni Mavronasiou ◽

Ioanna Xanthopoulou ◽

Vasileios Karantalis ◽

Grigorios Tsigkas ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Biodegradable Polymer ◽

Optical Coherence ◽

Polymer Carrier ◽

Biolimus A9 ◽

New Generation

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TCT-393: Five-year Clinical Results of the Biolimus A9 Eluting Stent with Biodegradable Polymer

The American Journal of Cardiology ◽

10.1016/j.amjcard.2009.08.419 ◽

2009 ◽

Vol 104 (6) ◽

pp. 146D ◽

Cited By ~ 1

Keyword(s):

Biodegradable Polymer ◽

Clinical Results ◽

Biolimus A9

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Fabrication of Microneedle from Stretched Biodegradable Polymer Sheet by 3D Laser Machining

Journal of Robotics and Mechatronics ◽

10.20965/jrm.2020.p0390 ◽

2020 ◽

Vol 32 (2) ◽

pp. 390-400

Author(s):

Seiji Aoyagi ◽

Junya Sato ◽

Tomokazu Takahashi ◽

Masato Suzuki ◽

Shinichi Matsumoto ◽

...

Keyword(s):

Injection Molding ◽

Femtosecond Laser ◽

Polylactic Acid ◽

Biodegradable Polymer ◽

Test Piece ◽

Three Dimensional ◽

Artificial Skin ◽

Laser Machining ◽

Resistance Force ◽

Fabrication Method

Polylactic acid (PLA) microneedles have been usually fabricated by injection molding. Herein, we consider microneedles that mimic the maxillae of mosquito proboscises, which have sharp tips with jagged harpoon-like protrusions. In case of such microneedles, filling the melting PLA resin up to the tip of the mold trough without burrs is challenging. To address this issue, we have proposed a new microneedle fabrication method in this paper. In this method, the needle with the desired shape was obtained from a PLA sheet by femtosecond laser machining. The needle was turned by 90°, and its tip further cut obliquely with the laser for three-dimensional (3D) sharpening. Tensile and buckling tests were conducted by using a test piece cut out from the PLA sheet. It was experimentally established that the strength and Young’s modulus along the sheet’s stretch direction are higher than those along its perpendicular direction. The 3D sharpened PLA microneedle successfully penetrated an artificial skin made of polydimethylsiloxane. A pair of microneedles were alternately vibrated against each other, mimicking the motion of mosquito two maxillae. With this alternate vibration, the resistance force during insertion was found to be lower compared to that without vibration.

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