scholarly journals Methotrexate-induced Pulmonary Toxicity Bronchiolitis Obliterans Organizing Pneumonia: A Rare Entity

Author(s):  
Gaurav Bhardwaj ◽  
Vikram Kumar Jain ◽  
Anubhav Sharma ◽  
Lokesh Maan

ABSTRACT Methotrexate is one of the most widely used broad-spectrum immunomodulator. It can be used as a primary option or as in combination of drugs in various immunological conditions. Generally, it is safe when use in lower dosages. However, a clinician has to be alert regarding some of its less common but toxic side-effects. Here, we discuss a rare case who developed methotrexate-induced pulmonary toxicity. How to cite this article Mishra M, Jain VK, Sharma A, Bhardwaj G, Maan L. Methotrexate-induced Pulmonary Toxicity Bronchiolitis Obliterans Organizing Pneumonia: A Rare Entity. J Mahatma Gandhi Univ Med Sci Tech 2016;1(2):64-65.

1996 ◽  
Vol 37 (3P2) ◽  
pp. 889-892 ◽  
Author(s):  
A. E. Voloudaki ◽  
D. E. Bouros ◽  
M. E. Froudarakis ◽  
G. E. Datseris ◽  
E. G. Apostolaki ◽  
...  

Two cases of idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) with unusual CT findings are presented. On CT both cases exhibited crescentic and ring-shaped opacities, surrounding areas of groundglass attenuation, and associated with a nodular pattern in one patient and airspace consolidations in the second patient. CT—pathologic correlation disclosed that the central areas of groundglass attenuation corresponded to alveolar septal inflammation, in contrast to the denser periphery where granulomatous tissue in peripheral airspaces predominated. In the broad spectrum of CT findings, BOOP can exhibit specific CT features with regard to the crescentic or ring-shaped opacities with a central groundglass attenuation area. Since these features have not been described in any other disease, they might be characteristic features for the diagnosis of BOOP.


2005 ◽  
Vol 59 (3) ◽  
pp. 315 ◽  
Author(s):  
Jong Hoo Lee ◽  
Myung Jae Park ◽  
Yi Hyung Kim ◽  
Byung Jo Park ◽  
Won Taek Oh ◽  
...  

2004 ◽  
Vol 10 (3) ◽  
pp. 456-459 ◽  
Author(s):  
Roopa Kohli-Seth ◽  
Claude Killu ◽  
May Jennifer Amolat ◽  
John Oropello ◽  
Anthony Manasia ◽  
...  

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