The upper gastrointestinal tract consists of the oesophagus, stomach, and the duodenum, which is the first section of the small bowel where pancreatic digestive juices and bile mix with food. The term hepatobiliary refers to the liver, gall bladder, and bile ducts. This chapter provides an overview of the conditions affecting the upper gastrointestinal tract and the hepatobiliary system, including the signs and symptoms, investigations, and treatments.