scholarly journals The role of latency period on the preterm premature rupture of membranes: implication for treatment

2021 ◽  
Author(s):  
Lin Lu ◽  
Jianhua Li ◽  
Bei Gan ◽  
Shan Zheng ◽  
Lihong Chen
Keyword(s):  
Logistic Regression ◽  
Amniotic Fluid ◽  
Influencing Factors ◽  
Gestational Age ◽  
Latency Period ◽  
Regression Analyses ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Amniotic Fluid Volume

IntroductionConservative treatments with latency period have been used for the treatment of preterm premature rupture of membranes (PPROM) in clinical practice, we aimed to evaluate the role and potential influencing factors of latency period, to provide insights to the clinical treatment of PPROM.Material and methodsPPROM pregnant women treated in our hospital from January 1, 2015 to September 30, 2020 were included. PPROM patients were divided into 48～168h group and the >168h latency group, the characteristics and prognosis of this two groups were compared and analyzed. Logistic regression analyses were conducted to analyze the relevant influencing factors of latency period.ResultsA total of 131 PPROM patients were included. There were significant differences on the age, BMI, gestational age on admission, amniotic fluid volume before childbirth, and positive rate of cervical secretion culture between two groups (all p<0.05). Logistic regression analyses indicated that the latency period was shorter in the PPROM patients with age≥30y(OR0.048, 95%CI0.121~0.863) and gestational age≥32w on admission(OR0.463, 95%CI0.069~0.811), and the latency period was prolonged in the PPROM patients with BMI≥23kg/㎡(OR1.591, 95%CI1.134~1.944) and amniotic fluid volume≥6cm(OR2.129, 95%CI1.093~3.042) (all p<0.05). There were significant differences in the incidence of low birth weight and NRDS between 48~168h group and >168h group (all p<0.05).ConclusionsLatency period plays an important role in the PPROM, which is associated with the pregnant women's age, BMI, gestational week of rupture and amniotic fluid index.

Fetal growth after preterm premature rupture of membranes: Is it related to amniotic fluid volume?

2007 ◽  
Vol 20 (5) ◽  
pp. 397-400 ◽  
Author(s):  
Shad H. Deering ◽  
Neeta Patel ◽  
Catherine Y. Spong ◽  
John C. Pezzullo ◽  
Alessandro Ghidini
Keyword(s):  
Amniotic Fluid ◽  
Fetal Growth ◽  
Fluid Volume ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Amniotic Fluid Volume

Effect of Amniotic Fluid Volume on Perinatal and Maternal Outcomes in Women With Preterm Premature Rupture of Membranes [390]

2015 ◽  
Vol 125 ◽  
pp. 121S
Author(s):  
Nicole V. Leal ◽  
Melania Maria Ramos Amorim ◽  
Antonio Henriques Franca Neto ◽  
Alex Sandro Rolland Souza ◽  
Fabiana O. Melo ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Fluid Volume ◽  
Maternal Outcomes ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Amniotic Fluid Volume

scholarly journals The effects of oligohydramnios on perinatal outcomes after preterm premature rupture of membranes

2021 ◽  
Vol 29 (1) ◽  
pp. 27-32
Author(s):  
Subhashini Ladella ◽  
David Lee ◽  
Fatemeh Abbasi ◽  
Brian Morgan
Keyword(s):  
Amniotic Fluid ◽  
Medical Center ◽  
Predictor Variable ◽  
Latency Period ◽  
Perinatal Outcomes ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Apgar Scores ◽  
Preterm Premature Rupture ◽  
Adverse Perinatal Outcomes

Objective Amniotic fluid plays a vital protective role in fetal growth and development. Low amniotic fluid index (AFI) during pregnancy increases risk of adverse perinatal outcomes. Prior studies reported association of oligohydramnios (AFI<5 cm) with shorter latency period and inconsistent correlation with chorioamnionitis after preterm premature rupture of membranes (PPROM). We studied effects of oligohydramnios on perinatal outcomes after PPROM. Methods A retrospective cross-sectional study was performed at our medical center on women with PPROM between 23 to 34 weeks during 2014 to 2016. The primary predictor variable was AFI of <5 cm or ≥5 cm in relationship to perinatal outcomes. Results From a total of 117 PPROM cases reviewed, 46 women had AFI<5 cm and 71 had AFI≥5 cm. Length of stay (LOS) in neonatal intensive care unit (NICU) was 42 days for AFI<5 cm versus 26.5 days for AFI>5 cm (p<0.007). The mean neonatal Apgar scores at 1 and 5 minutes (5.2 and 7.4 respectively) were lower in the AFI<5 cm group compared to AFI≥5 cm (6.9 at 1 minute and 8.4 at 5 minutes, p<0.001). Conclusion Oligohydramnios after PPROM is associated with adverse perinatal outcomes such as lower Apgar scores and longer LOS in the NICU. No association was observed with latency period and chorioamnionitis.

scholarly journals Evaluation of perinatal outcomes in pregnant women with preterm premature rupture of membranes

2016 ◽  
Vol 62 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Alex Sandro Rolland Souza ◽  
Adriane Farias Patriota ◽  
Gláucia Virgínia de Queiroz Lins Guerra ◽  
Brena Carvalho Pinto de Melo
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Gestational Age ◽  
Perinatal Outcomes ◽  
Perinatal Complications ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Amniotic Fluid Index ◽  
Apgar Scores ◽  
Preterm Premature Rupture

SUMMARY Objective: To determine the association between amniotic fluid index (AFI) and perinatal outcomes in preterm premature rupture of membranes (PPROM). Method: A retrospective cohort study was conducted between 2008 and 2012. 86 pregnant women were included, with a diagnosis of PPROM and gestational age from 24 to 35 weeks. Women who presented hypertensive disorders, diabetes, fetuses with birth defects and infection at admission were excluded. To determine the association between AFI and perinatal outcomes, chi-square and Fisher’s exact test were used if necessary, as well as risk ratio (RR) and 95% confidence intervals (95CI). Correlation between AFI and perinatal outcomes was determined by using simple linear regression, and AFI progression during pregnancy was analyzed by Z-test. Results: When comparing newborns presenting ultrasound with AFI<5cm and AFI>5cm, there was a higher frequency of perinatal mortality when the AFI was lower than 5 cm. However, when the oligohydramnios was diagnosed as severe (AFI<3cm), there was a higher frequency of Apgar scores less than seven at 1 minute, neonatal sepsis and early neonatal mortality compared to those presenting AFI>3cm. There was a positive correlation between AFI and gestational age at delivery, birth weight and Apgar scores at minutes 1 and 5. There was also a decrease in amniotic fluid volume with increased gestational age. Conclusion: The presence of severe oligohydramnios after PPROM contributed to a higher frequency of perinatal complications and death.

scholarly journals The earlier the gestational age, the greater the intensity of the intra-amniotic inflammatory response in women with preterm premature rupture of membranes and amniotic fluid infection by Ureaplasma species

2019 ◽  
Vol 47 (5) ◽  
pp. 516-527 ◽  
Author(s):  
Kyung Joon Oh ◽  
Roberto Romero ◽  
Jee Yoon Park ◽  
Joon-Seok Hong ◽  
Bo Hyun Yoon
Keyword(s):  
Inflammatory Response ◽  
Amniotic Fluid ◽  
Gestational Age ◽  
Maternal Blood ◽  
Late Preterm ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Group 2 ◽  
Wbc Count

AbstractObjectivesTo determine the relationship between the intensity of the intra-amniotic inflammatory response and the gestational age at the time of diagnosis in cases with preterm premature rupture of membranes (PROM) and intra-amniotic infection caused byUreaplasmaspp.MethodsA retrospective cohort study was conducted which included 71 women with preterm PROM and a positive amniotic fluid culture withUreaplasmaspp. Women with mixed intra-amniotic infections were excluded. The study population was classified into three groups according to gestational age: group 1, <26 weeks (extreme preterm PROM, n = 17); group 2, 26.0–33.9 weeks (moderate preterm PROM, n = 39); group 3, 34.0–36.9 weeks (late preterm PROM, n = 15). The intensity of the intra-amniotic and maternal inflammatory response was compared among the three groups. The intensity of the intra-amniotic inflammatory response was assessed by the concentration of amniotic fluid matrix metalloproteinase-8 (MMP-8) and white blood cell (WBC) count. The maternal inflammatory response was assessed by the concentration of C-reactive protein (CRP) and WBC count in maternal blood at the time of amniocentesis.Results(1) The median values of amniotic fluid MMP-8 concentration and WBC count were the highest in the extreme preterm PROM group and the lowest in the late preterm PROM group (P < 0.001 and P = 0.01, respectively); (2) the intensity of the maternal inflammatory response measured by maternal blood WBC count and CRP concentration was not significantly associated with gestational age at the time of diagnosis.ConclusionThe earlier the gestational age at the time of PROM, the higher the intensity of the intra-amniotic inflammatory response in women with preterm PROM and intra-amniotic infection caused byUreaplasmaspp.

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