scholarly journals Medication Administration With Inhalers or Nebulizers

2021 ◽  
Vol 1 (11) ◽  
Author(s):  
Khai Than ◽  
Aleksandra Grobelna
Keyword(s):  
Clinical Effectiveness ◽  
Medication Administration ◽  
Chronic Obstructive ◽  
Dry Powder Inhalers ◽  
Metered Dose Inhalers ◽  
Dry Powder ◽  
Obstructive Pulmonary Disease ◽  
Metered Dose ◽  
The Cost ◽  
Evidence Based Guidelines

Delivery of medication via metered-dose inhalers to children or adults with asthma, or adults with chronic obstructive pulmonary disease at emergency departments or intensive care units, may be as effective as nebulizers in terms of clinical parameters and health care resource use. Limited data on adverse events showed no significant differences between metered-dose inhalers and nebulizers. No evidence was found on the clinical effectiveness of dry powder inhalers in comparison with nebulizers or metered-dose inhalers. No evidence was found on the cost-effectiveness of medication administration via metered-dose inhalers, nebulizers, or dry powder inhalers in comparison with each other. No evidence-based guidelines with recommendations regarding the comparative use of metered-dose inhalers, dry powder inhalers, or nebulizers for administration of medication were identified.

scholarly journals Patterns of use of dry powder inhalers versus pressurized metered-dose inhalers devices in adult patients with chronic obstructive pulmonary disease or asthma: An observational comparative study

2017 ◽  
Vol 14 (3) ◽  
pp. 309-320 ◽  
Author(s):  
Wijdan H Ramadan ◽  
Aline T Sarkis
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Adult Patients ◽  
Chronic Obstructive ◽  
Dry Powder Inhalers ◽  
Metered Dose Inhalers ◽  
Dry Powder ◽  
Obstructive Pulmonary Disease ◽  
Metered Dose ◽  
Pressurized Metered Dose Inhalers

Numerous patients with chronic obstructive pulmonary disease (COPD) and asthma do not use inhaler devices properly, which can contribute to poor disease control. The objective of this study is to assess the technical and safety use of dry powder inhalers (DPIs) versus pressurized metered-dose inhalers (MDIs) in adult patients with COPD or asthma in Lebanon. A concurrent, prospective comparative observational study was conducted at one hospital and 15 community pharmacies in Lebanon. Over a period of 18 months, 246 questionnaires were filled. Patients included were adults with COPD or asthma. Answers were entered into the Statistical Package for Social Sciences software and excel sheet. T-test and correlation were used to analyze the results; 67.8% and 38.4% of those using DPIs and MDIs, respectively, performed the exact technical steps adequately ( p = 0.003, relative risk: 2.134, 95% confidence interval: 0.910–4.842). When compared to MDI, a higher percentage of DPI users found their devices easy to use. Moreover, 81.4% of the MDI users found difficulty in coordinating between pressing the canister and inhaling. Rates of exacerbations were significantly higher in MDIs vs. DPI users (59.4% vs. 21.7%). Overall, 44.31% of patients did not receive education from their healthcare professionals about the devices. A significant number of COPD/asthma adult patients do not use their devices properly. Even though DPIs were significantly easier to use, proper education on the technical use of all types of inhalers is needed.

Design of a Metered-Dose Inhaler Actuated by Shape Memory Alloy

2019 ◽  
Vol 2 (3) ◽  
Author(s):  
Brent Utter
Keyword(s):  
Shape Memory Alloy ◽  
Shape Memory ◽  
Dose Inhaler ◽  
Chronic Obstructive ◽  
Metered Dose Inhalers ◽  
Obstructive Pulmonary Disease ◽  
Metered Dose ◽  
Sma Actuator ◽  
Differential Pressure Sensor ◽  
Inhaled Medication

The global prevalence of asthma and chronic obstructive pulmonary disease (COPD) is on the order of hundreds of millions of individuals. The most common treatment approach is to take a self-administered inhaled medication. This study focuses on pressurized metered-dose inhalers (MDIs) where, unfortunately, rates of mishandling and misuse are extremely high and lead to improper treatment. One significant challenge results from the timing miscoordination of the medicine dispersion and inhalation breath. To address this, this study demonstrates the feasibility of automating the timing of the medicine dispersion by integrating a shape memory alloy (SMA) actuator and a differential pressure sensor into the casing of a traditional MDI. The approach is to measure the vacuum pressure created by an inspiratory breath, evaluate criteria indicating an acceptable breath, and if those criteria are met, heat the SMA actuator to depress the cartridge and disperse medicine. To meet actuation requirements and reliably depress the inhaler cartridge, two concepts for configuring an SMA wire were designed and compared with respect to complexity, actuation timing, and energy consumption. The proposed concept was able to disperse medicine in 263 ms, averaged over 100 actuations on a single battery charge, facilitating the early dispersion of medicine during an inhalation breath. By describing the design process of an SMA-actuated MDI that does not result in a significant increase of its weight or size, this study provides a practical technological approach for reducing the improper treatment of asthma and COPD due to timing miscoordination.

Equivalence testing and equivalence limits of metered-dose inhalers and dry powder inhalers measured by in vitro impaction

2000 ◽  
Vol 49 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Marjolein Weda ◽  
Eduard R.M Geuns ◽  
Raymond C.R Vermeer ◽  
Nathalie R.A Buiten ◽  
Kirsten Hendriks-de Jong ◽  
...  
Keyword(s):  
Dry Powder Inhalers ◽  
Equivalence Testing ◽  
Metered Dose Inhalers ◽  
Dry Powder ◽  
Metered Dose
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