Epidemiology of adult chronic cough: disease burden, regional issues, and recent findings

Chronic cough: new insights and future prospects

European Respiratory Review ◽

10.1183/16000617.0127-2021 ◽

2021 ◽

Vol 30 (162) ◽

pp. 210127

Author(s):

Alyn Morice ◽

Peter Dicpinigaitis ◽

Lorcan McGarvey ◽

Surinder S. Birring

Keyword(s):

Chronic Cough ◽

Disease Burden ◽

Unmet Need ◽

Standard Of Care ◽

Underlying Disease ◽

Disease Mechanisms ◽

Current Review ◽

Standard Of Care Treatment ◽

Underlying Pathology

Chronic cough is defined in adults as a cough that lasts for ≥8 weeks. When it proves intractable to standard-of-care treatment, it can be referred to as refractory chronic cough (RCC). Chronic cough is now understood to be a condition of neural dysregulation. Chronic cough and RCC result in a serious, often unrecognized, disease burden, which forms the focus of the current review.The estimated global prevalence of chronic cough is 2–18%. Patients with chronic cough and RCC report many physical and psychological effects, which impair their quality of life. Chronic cough also has a significant economic burden for the patient and healthcare systems. RCC diagnosis and treatment are often delayed for many years as potential treatable triggers must be excluded first and a stepwise empirical therapeutic regimen is recommended.Evidence supporting most currently recommended treatments is limited. Many treatments do not address the underlying pathology, are used off-label, have limited efficacy and produce significant side-effects. There is therefore a significant unmet need for alternative therapies for RCC that target the underlying disease mechanisms. Early clinical data suggest that antagonists of the purinergic P2X3 receptor, an important mediator of RCC, are promising, though more evidence is needed.

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Disease Burden Of Idiopathic Chronic Cough (Icc) And Chronic Cough (Cc) In Copd, Ipf And Lung Cancer (Lc): An Exploratory Literature Review

Value in Health ◽

10.1016/j.jval.2013.03.1174 ◽

2013 ◽

Vol 16 (3) ◽

pp. A231

Author(s):

S. Gonzalez McQuire ◽

I. Kucmin-Bemelmans ◽

M. Hensen

Keyword(s):

Lung Cancer ◽

Literature Review ◽

Chronic Cough ◽

Disease Burden

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Impact and disease burden of chronic cough

Asia Pacific Allergy ◽

10.5415/apallergy.2021.11.e22 ◽

2021 ◽

Vol 11 (2) ◽

Cited By ~ 1

Author(s):

Ha-Kyeong Won ◽

Woo-Jung Song

Keyword(s):

Chronic Cough ◽

Disease Burden

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A SURVEY OF PATIENT'S PERCEPTION OF DISEASE BURDEN IN CHRONIC COUGH

CHEST Journal ◽

10.1378/chest.128.4_meetingabstracts.294s-b ◽

2005 ◽

Vol 128 (4) ◽

pp. 294S

Author(s):

Kaiser G. Lim ◽

Ashok Patel ◽

Timothy I. Morgenthaler

Keyword(s):

Chronic Cough ◽

Disease Burden ◽

Patient’S Perception ◽

Perception Of Disease

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The Collaborative Medical and Behavioral Management of Chronic Cough

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd19.2.49 ◽

2009 ◽

Vol 19 (2) ◽

pp. 49-57

Author(s):

Brian E. Petty ◽

Seth H. Dailey

Keyword(s):

Medical Care ◽

Chronic Cough ◽

Therapeutic Management ◽

Ambulatory Setting ◽

Behavioral Management ◽

Speech Language Pathologists ◽

Speech Language Pathologist ◽

The Many ◽

Frequent Reason

Abstract Chronic cough is the most frequent reason cited by patients for seeking medical care in an ambulatory setting and may account for 10% to 38% of a pulmonologist's practice. Because chronic cough can be caused by or correlated with a wide array of disorders and behaviors, the diagnosis of etiologic factors and determination of appropriate therapeutic management in these cases can prove to be daunting for the physician and speech-language pathologist alike. This article will describe the phenomenon of chronic cough, discuss the many etiologic factors to consider, and review some of the more common ways in which speech-language pathologists and physicians collaborate to treat this challenging condition.

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Chronic Refractory Cough: A Case Study

Perspectives of the ASHA Special Interest Groups ◽

10.1044/persp2.sig3.57 ◽

2017 ◽

Vol 2 (3) ◽

pp. 57-62

Author(s):

Anna Maria Siciliano

Keyword(s):

Quality Of Life ◽

Adult Female ◽

Chronic Cough ◽

Treatment Regime ◽

Speech Language Pathology ◽

Old Adult ◽

Language Pathology

This paper presents a successful behavioral case study in treatment of chronic refractory cough in a 60-year-old adult female. The efficacy for speech-language pathology treating chronic cough is discussed along with description of treatment regime. Discussion focuses on therapy approaches used and the patient's report of changes in quality of life and frequency, duration, and severity reduction of her cough after treatment.

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