scholarly journals HMG-CoA Reductase Inhibitory Activity of Gnetum gnemon Seed Extract and Identification of Potential Inhibitors for Lowering Cholesterol Level

2017 ◽  
Vol 9 (4) ◽  
pp. 559-565 ◽  
Author(s):  
Kholid Abdul Hafidz ◽  
Nuraini Puspitasari ◽  
Azminah A ◽  
Arry Yanuar ◽  
Yuditya Artha ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Inhibitory Activity ◽  
Seed Extract ◽  
Hmg Coa Reductase ◽  
Gnetum Gnemon ◽  
Coa Reductase ◽  
Potential Inhibitors

In vitro antioxidant, antiglycation, and enzymatic inhibitory activity against α-glucosidase, α-amylase, lipase and HMG-CoA reductase of Terminalia boivinii Tul.

2021 ◽  
pp. 102235
Author(s):  
Bongani Sicelo Dlamini ◽  
Carlos Eduardo Hernandez ◽  
Chiy-Rong Chen ◽  
Wen-Ling Shih ◽  
Jue-Liang Hsu ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Hmg Coa Reductase ◽  
Coa Reductase

scholarly journals HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia

2015 ◽  
pp. 509 ◽  
Author(s):  
Gunasekaran Baskaran ◽  
Mohd Yunus Shukor ◽  
Shamala Salvamani ◽  
Siti Aqlima Ahmad ◽  
Noor Azmi Shaharuddin ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Leaf Extract ◽  
Hmg Coa Reductase ◽  
Basella Alba ◽  
Coa Reductase

scholarly journals Influence of extraction methods of bay leaves (Syzygium polyanthum) on antioxidant and HMG-CoA Reductase inhibitory activity

Heliyon ◽  
2019 ◽  
Vol 5 (4) ◽  
pp. e01485
Author(s):  
Lanny Hartanti ◽  
Stefania Maureen Kasih Yonas ◽  
Josianne Jacqlyn Mustamu ◽  
Sumi Wijaya ◽  
Henry Kurnia Setiawan ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Extraction Methods ◽  
Hmg Coa Reductase ◽  
Coa Reductase

A Novel Anabolic Agent: A Simvastatin Analogue without HMG-CoA Reductase Inhibitory Activity

2014 ◽  
Vol 16 (17) ◽  
pp. 4376-4379 ◽  
Author(s):  
Kuang-Chan Hsieh ◽  
Chai-Lin Kao ◽  
Chien-Wei Feng ◽  
Zhi-Hong Wen ◽  
Hsin-Fang Chang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Hmg Coa Reductase ◽  
Anabolic Agent ◽  
Coa Reductase

scholarly journals Ameliorations in the Biomarker Indices of Dyslipidemia and Atherosclerotic Plaque by the Inhibition of HMG – CoA Reductase and Antioxidant Potential of Phytoconstituents of an Aqueous Seed Extract of Acacia Senegal (L.) Willd in Rabbits

2021 ◽  
Author(s):  
Jaykaran Charan ◽  
Priyanka Riyad ◽  
Heera Ram ◽  
Ashok Purohit ◽  
Sneha Ambwani ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
In Silico ◽  
Risk Index ◽  
Seed Extract ◽  
Atherogenic Index ◽  
Acacia Senegal ◽  
Hmg Coa Reductase ◽  
Coa Reductase

Abstract Background: The HMG-CoA inhibitor are used to control adverse cardiovascular event caused by Hypercholesterolemia and dyslipidaemia. The current study was aimed to evaluate the ability of phytoconstituents of an aqueous seed extract of Acacia senegal (L.) Willd to inhibit HMG-CoA reductase and regress the formation of atherosclerotic plaque. Methods: The chemical fingerprinting of the test extract was assessed by LC-MS. Consequently, the assessments of in-vitro, in-vivo, and in-silico were performed by following the standard methods.Results: The in-vitro assessment of the test extract revealed 74.1 % inhibition potential of HMG-CoA reductase. In-vivo evaluations of the test extract indicated that treated hypercholesterolemic rabbits exhibited a significant (𝑃 ≤ 0.001) ameliorations in the biomarker indices of the dyslipidaemia, such as the atherogenic index, Castelli risk index (I&II), atherogenic coefficient along with lipid profile. Concomitantly, significant reductions were observed in the atherosclerotic plaque area and antioxidants. The in-silico study of molecular docking shown interactions capabilities of key phytoconstituents of the test extract with target protein of HMG-CoA reductase which further validated by the molecular dynamics through potentail energy, NPT, NVT, RSMD and others. Subsequently, the ADMET analysis shown ideal druggability. Conclusion: The results indicate that phytoconstituents of an aqueous seed extract of Acacia senegal (L.) Willd. could inhibit HMG-CoA reductase and improve the levels of antioxidants activity that may reduce symptoms associated with hypercholesterolemia.

scholarly journals HMG-CoA Reductase Inhibitory Activity of Garcinia latissima Miq. Mesocarp Water Extract for Herbal Tea

2018 ◽  
Vol 10 (6s) ◽  
pp. s141-s146
Author(s):  
Herra Williany Monalissa ◽  
Berna Elya ◽  
Nuraini Puspitasari
Keyword(s):  
Inhibitory Activity ◽  
Water Extract ◽  
Herbal Tea ◽  
Hmg Coa Reductase ◽  
Coa Reductase

In silico Screening of Selected Flavanones for HMG CoA Reductase Inhibitory Activity

2020 ◽  
Vol 14 (5) ◽  
pp. 128-139
Author(s):  
Tan Ker Ying ◽  
Mohamed Saleem Abdul Shukkoor ◽  
Shaik Ibrahim Khalivulla
Keyword(s):  
Inhibitory Activity ◽  
In Silico ◽  
In Silico Screening ◽  
Hmg Coa Reductase ◽  
Coa Reductase
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